Search Results - "Léger, Olivier J.P"

Humanization of a mouse antibody against human alpha-4 integrin: a potential therapeutic for the treatment of multiple sclerosis by Léger, O J, Yednock, T A, Tanner, L, Horner, H C, Hines, D K, Keen, S, Saldanha, J, Jones, S T, Fritz, L C, Bendig, M M

“…alpha 4 beta 1 integrin (VLA-4) is crucial for the adhesion of leukocytes to human vascular cell adhesion molecule-1 (VCAM-1) on inflamed endothelium. This…”
Get more information

A single backmutation in the human kIV framework of a previously unsuccessfully humanized antibody restores the binding activity and increases the secretion in cos cells by Saldanha, José W, Martin, Andrew C.R, Léger, Olivier J.P

“…Humanization of rodent mAbs by CDR-grafting (also called “reshaping”) is now a standard procedure for reducing immunogenicity and recruiting human effector…”
Get full text

Isolation and characterization of a monoclonal rheumatoid factor specific for the hinge region of rat IgG2b by Léger, O J, Dean, C J

“…The isolation and characterization of an isotype-specific autoantibody-secreting hybridoma NET/2/3 from rats bearing the syngeneic tumour HSN is described…”
Get more information