Search Results - "Léger, David Y."

Berberis libanotica extract targets NF-κB/COX-2, PI3K/Akt and mitochondrial/caspase signalling to induce human erythroleukemia cell apoptosis by DIAB, SAADA, FIDANZI, CHLOE, LÉGER, DAVID Y, GHEZALI, LAMIA, MILLOT, MARION, MARTIN, FRÉDÉRIQUE, AZAR, RANIA, ESSEILY, FADI, SAAB, ANTOINE, SOL, VINCENT, DIAB-ASSAF, MONA, LIAGRE, BERTRAND

“…The aim of this study was to describe and understand the relationship between cyclooxygenase-2 (COX-2) expression and apoptosis rate in erythroleukemia cells…”
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Development of curcumin–cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems by Ndong Ntoutoume, Gautier M.A., Granet, Robert, Mbakidi, Jean Pierre, Brégier, Frédérique, Léger, David Y., Fidanzi-Dugas, Chloë, Lequart, Vincent, Joly, Nicolas, Liagre, Bertrand, Chaleix, Vincent, Sol, Vincent

“…[Display omitted] The synthesis of curcumin–cyclodextrin/cellulose nanocrystals (CNCx) nano complexes was performed. CNCx were functionalized by ionic…”
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Porphyrin/Chlorin Derivatives as Promising Molecules for Therapy of Colorectal Cancer by Dandash, Fatima, Leger, David Y, Diab-Assaf, Mona, Sol, Vincent, Liagre, Bertrand

“…Colorectal cancer (CRC) is a leading cause of cancer-related death. The demand for new therapeutic approaches has increased attention paid toward therapies…”
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Design and synthesis of zinc protoporphyrin IX-adamantane/cyclodextrin/cellulose nanocrystals complexes for anticancer photodynamic therapy by Ndong Ntoutoume, Gautier M.A., Granet, Robert, Mbakidi, Jean-Pierre, Constantin, Eléna, Bretin, Ludovic, Léger, David Y., Liagre, Bertrand, Chaleix, Vincent, Brégier, Frédérique, Sol, Vincent

“…[Display omitted] Two protoporphyrin IX (PpIX) adamantane derivatives were synthesized and then metallated with zinc. The Zn-PpIX derivatives, exhibiting a…”
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α5β1 integrin antagonists reduce chemotherapy‐induced premature senescence and facilitate apoptosis in human glioblastoma cells by Martinkova, Eva, Maglott, Anne, Leger, David Y., Bonnet, Dominique, Stiborova, Marie, Takeda, Ken, Martin, Sophie, Dontenwill, Monique

“…The α5β1 integrin represent a new therapeutic target for glioblastoma, which are malignant brain tumors difficult to cure with conventional therapies…”
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Design and multi-step synthesis of chalcone-polyamine conjugates as potent antiproliferative agents by Rioux, Benjamin, Pouget, Christelle, Fidanzi-Dugas, Chloë, Gamond, Aurélie, Laurent, Aurélie, Semaan, Josiane, Pinon, Aline, Champavier, Yves, Léger, David Y., Liagre, Bertrand, Duroux, Jean-Luc, Fagnère, Catherine, Sol, Vincent

“…[Display omitted] The aim of this study is to synthesize chalcone-polyamine conjugates in order to enhance bioavailability and selectivity of chalcone core…”
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Citral inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 cells by Chaouki, Wahid, Leger, David Y., Liagre, Bertrand, Beneytout, Jean-Louis, Hmamouchi, Mohamed

“…Many natural components of plants extract are studied for their beneficial effects on health and particularly on carcinogenesis chemoprevention. In this study,…”
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Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model by van Rixel, Vincent H. S, Ramu, Vadde, Auyeung, Austin B, Beztsinna, Nataliia, Leger, David Y, Lameijer, Lucien N, Hilt, Stan T, Le Dévédec, Sylvia E, Yildiz, Tugba, Betancourt, Tania, Gildner, M. Brenton, Hudnall, Todd W, Sol, Vincent, Liagre, Bertrand, Kornienko, Alexander, Bonnet, Sylvestre

“…Marine alkaloid rigidins are cytotoxic compounds known to kill cancer cells at nanomolar concentrations by targeting the microtubule network. Here, a rigidin…”
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Delivery of tanshinone IIA and α-mangostin from gold/PEI/cyclodextrin nanoparticle platform designed for prostate cancer chemotherapy by Qiu, Shihong, Granet, Robert, Mbakidi, Jean-Pierre, Brégier, Frédérique, Pouget, Christelle, Micallef, Ludovic, Sothea-Ouk, Tan, Leger, David Y., Liagre, Bertrand, Chaleix, Vincent, Sol, Vincent

“…[Display omitted] A new anti-cancer drug delivery system, based on gold nanoparticles, has been designed for hydrophobic active compounds. The system is a…”
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Integrin α5β1 Plays a Critical Role in Resistance to Temozolomide by Interfering with the p53 Pathway in High-Grade Glioma by JANOUSKOVA, Hana, MAGLOTT, Anne, ENTZ-WERLE, Natacha, LEHMANN-CHE, Jacqueline, GODET, Julien, MARTIN, Sophie, TEISINGER, Jan, DONTENWILL, Monique, LEGER, David Y, BOSSERT, Catherine, NOULET, Fanny, GUERIN, Eric, GUENOT, Dominique, PINEL, Sophie, CHASTAGNER, Pascal, PLENAT, François

“…Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. In this study, we show that high expression of the α5 integrin…”
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Polypharmacy, potentially inappropriate medications and drug-drug interactions in geriatric patients with hematologic malignancy: Observational single-center study of 122 patients by Leger, David Y., Moreau, Stephane, Signol, Nicolas, Fargeas, Jean-Baptiste, Picat, Marie-Agnès, Penot, Amélie, Abraham, Julie, Laroche, Marie-Laure, Bordessoule, Dominique

“…Geriatric patients with hematologic malignancies (HMs) are prescribed targeted and supportive care treatments that add to the preexisting polypharmacy (PP). PP…”
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Chemical Composition and Antioxidant, Anti-Inflammatory, and Antiproliferative Activities of Lebanese Ephedra Campylopoda Plant by Kallassy, Hany, Fayyad-Kazan, Mohammad, Makki, Rawan, El-Makhour, Yolla, Rammal, Hasan, Leger, David Y, Sol, Vincent, Fayyad-Kazan, Hussein, Liagre, Bertrand, Badran, Bassam

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Antiproliferative effect of extracts from Aristolochia baetica and Origanum compactum on human breast cancer cell line MCF-7 by Chaouki, Wahid, Leger, David Y, Eljastimi, Jamila, Beneytout, Jean-Louis, Hmamouchi, Mohamed

“…Aristolochia baetica L. (Aristolochiaceae) and Origanum compactum Benth. (Lamiaceae) are native plants of Morocco used in traditional medicine. In order to…”
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2′-Hydroxy-4-methylsulfonylchalcone enhances TRAIL-induced apoptosis in prostate cancer cells by Ismail, Bassel, Fagnere, Catherine, Limami, Youness, Ghezali, Lamia, Pouget, Christelle, Fidanzi, Chloë, Ouk, Catherine, Gueye, Rokhaya, Beneytout, Jean-Louis, Duroux, Jean-Luc, Diab-Assaf, Mona, Leger, David Y, Liagre, Bertrand

“…Prostate cancer is the most common malignant cancer in men and the second leading cause of cancer deaths. Previously, we have shown that…”
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Novel methylsulfonyl chalcones as potential antiproliferative drugs for human prostate cancer: Involvement of the intrinsic pathway of apoptosis by ISMAIL, BASSEL, GHEZALI, LAMIA, GUEYE, ROKHAYA, LIMAMI, YOUNESS, POUGET, CHRISTELLE, LEGER, DAVID Y, MARTIN, FREDERIQUE, BENEYTOUT, JEAN-LOUIS, DUROUX, JEAN-LUC, DIAB-ASSAF, MONA, FAGNERE, CATHERINE, LIAGRE, BERTRAND

“…Limited success has been achieved in extending the survival of patients with metastatic and hormone-refractory prostate cancer (HRPC). There is a strong need…”
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Chemical Composition, Antioxidant, Anti-Inflammatory, and Antiproliferative Activities of the Plant Lebanese Crataegus Azarolus L by Kallassy, Hany, Fayyad-Kazan, Mohammad, Makki, Rawan, El-Makhour, Yolla, Hamade, Eva, Rammal, Hasan, Leger, David Y, Sol, Vincent, Fayyad-Kazan, Hussein, Liagre, Bertrand, Badran, Bassam

“…BACKGROUND In the present study, phytochemical screening, antioxidant, anti-inflammatory, and antiproliferative capacities of 3 extracts from leaves of…”
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Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-kappaB binding by Liagre, Bertrand, Bertrand, Julian, Leger, David Y, Beneytout, Jean-Louis

“…Diosgenin is a steroidal sapogenin with antitumor properties. We previously showed that diosgenin induced apoptosis in human erythroleukemia (HEL) cells. In…”
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Role of MAPKs and NF-κB in diosgenin-induced megakaryocytic differentiation and subsequent apoptosis in HEL cells by LEGER, David Y, LIAGRE, Bertrand, BENEYTOUT, Jean-Louis

“…Megakaryocytopoiesis is characterized by progressive polyploidization and acquisition of megakaryocytic markers. MAPK pathways play a key role during…”
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MAP kinase subtypes and Akt regulate diosgenin-induced apoptosis of rheumatoid synovial cells in association with COX-2 expression and prostanoid production by Liagre, Bertrand, Leger, David, Vergne-Salle, Pascale, Beneytout, Jean

“…In the present study, we investigated the signalling pathways involved in diosgenin-induced apoptosis in human rheumatoid arthritis (RA) fibroblast-like…”
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Diosgenin induces cell cycle arrest and apoptosis in HEL cells with increase in intracellular calcium level, activation of cPLA2 and COX-2 overexpression by Leger, David Y, Liagre, Bertrand, Corbière, Cécile, Cook-Moreau, Jeanne, Beneytout, Jean-Louis

“…Many natural components of plant extracts are studied for their beneficial effects for health and particularly on carcinogenesis chemoprevention. In the…”
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