Search Results - "LÜBBERT, Hermann"

Olfaction in three genetic and two MPTP-induced Parkinson's disease mouse models by Kurtenbach, Stefan, Wewering, Sonja, Hatt, Hanns, Neuhaus, Eva M, Lübbert, Hermann

“…Various genetic or toxin-induced mouse models are frequently used for investigation of early PD pathology. Although olfactory impairment is known to precede…”
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Parkin directly modulates 26S proteasome activity by Um, Ji Won, Im, Eunju, Lee, Hyun Jung, Min, Boram, Yoo, Lang, Yoo, Jiho, Lübbert, Hermann, Stichel-Gunkel, Christine, Cho, Hyun-Soo, Yoon, Jong Bok, Chung, Kwang Chul

“…Parkinson's disease (PD) is a common neurodegenerative disease that involves the deterioration of dopaminergic neurons in the substantia nigra pars compacta…”
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The mouse MPTP model: gene expression changes in dopaminergic neurons by Kühn, Kati, Wellen, Jennifer, Link, Nina, Maskri, Lyutha, Lübbert, Hermann, Stichel, Christine C.

“…Parkinson's disease (PD) is a common neurodegenerative disorder, characterized by the progressive loss of dopaminergic neurons in the substantia nigra…”
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Analgesic and antiinflammatory effects of cannabinoid receptor agonists in a rat model of neuropathic pain by Leichsenring, Anna, Andriske, Michael, Bäcker, Ingo, Stichel, Christine C., Lübbert, Hermann

“…Cannabinoid receptor (CB) agonists are known to attenuate allodynia in a range of pain models, but their long-term effects and their mechanisms of action are…”
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Cloning and characterization of MUPP1, a novel PDZ domain protein by Ullmer, Christoph, Schmuck, Karin, Figge, Andrea, Lübbert, Hermann

“…Using the yeast two-hybrid system we isolated a cDNA clone encoding a novel protein interacting with the C-terminal domain of the 5-HT 2C receptor. The…”
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Expression of serotonin receptor mRNAs in blood vessels by Ullmer, Christoph, Schmuck, Karin, Kalkman, Hans O., Lübbert, Hermann

“…Using RT-PCR we distinguished mRNAs for all known G-protein coupled serotonin receptors expressed in various rat and porcine blood vessels. Nearly all vessels…”
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The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson’s disease by Scheller, Dieter, Ullmer, Christoph, Berkels, Reinhard, Gwarek, Mirella, Lübbert, Hermann

“…Rotigotine (Neupro®) is a non-ergoline dopamine agonist developed for the once daily treatment of Parkinson’s disease (PD) using a transdermal delivery system…”
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Ascending neuropathology in the CNS of a mutant SOD1 mouse model of amyotrophic lateral sclerosis by Leichsenring, Anna, Linnartz, Bettina, Zhu, Xin-Ran, Lübbert, Hermann, Stichel, Christine C.

“…Transgenic mice expressing a mutated human Cu/Zn superoxide dismutase (SOD1) gene develop a motor neuron disease similar to familial amyotrophic lateral…”
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Cloning and functional characterization of the human 5‐HT2B serotonin receptor by Schmuck, Karin, Ullmer, Christoph, Engels, Peter, Lübbert, Hermann

“…Recently, we have reported the cloning of the rat 5‐HT2B receptor cDNA. This receptor is particularly interesting since it may be involved in diseases such as…”
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Expression and regulation of human and rat phosphodiesterase type IV isogenes by Engels, Peter, Fichtel, Katharina, Lübbert, Hermann

“…Type IV phosphodiesterases (PDE IV) specifically hydrolyze cAMP and are inhibited by rolipram. RT-PCR was applied to analyze the expression patterns of mRNAs…”
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Intra- versus extracellular effects of microglia-derived cysteine proteases in a conditioned medium transfer model by Wendt, Wiebke, Schulten, Roxane, Stichel, Christine C, Lübbert, Hermann

“…Activated microglia release inflammatory mediators that display either beneficial or harmful effects on neuronal survival and signaling. In the present study…”
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Structural features of a close homologue of L1 (CHL1) in the mouse: a new member of the L1 family of neural recognition molecules by Holm, J, Hillenbrand, R, Steuber, V, Bartsch, U, Moos, M, Lübbert, H, Montag, D, Schachner, M

“…We have identified a close homologue of L1 (CHL1) in the mouse. CHL1 comprises an N-terminal signal sequence, six immunoglobulin (Ig)-like domains, 4.5…”
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Non-motor behavioural impairments in parkin-deficient mice by Zhu, Xin-Ran, Maskri, Lyutha, Herold, Christina, Bader, Verian, Stichel, Christine C., Güntürkün, Onur, Lübbert, Hermann

“…Mutations in the parkin gene are the major cause of early‐onset familial Parkinson's disease (PD). We previously reported the generation and analysis of a…”
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Differential expression of cathepsin X in aging and pathological central nervous system of mice by Wendt, Wiebke, Zhu, Xin-Ran, Lübbert, Hermann, Stichel, Christine C.

“…Increasing evidence of a fundamental influence of cathepsins on inflammation has drawn interest in a thorough understanding of their role in physiological and…”
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Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain by Kaupmann, Klemens, Bruns, Christian, Hoyer, Daniel, Seuwen, Klaus, Lübbert, Hermann

“…The mRNA distribution in the brain and the coupling to cellular effector systems of four somatostatin receptors (SSTR1-4) was studied. All four SRIF receptor…”
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Histological investigations on the dura mater vascular system of mice by Mecheri, Badreddine, Paris, Frank, Lübbert, Hermann

“…The human dura mater encephali is a well innervated and vascularized membrane. Its vascular system plays a crucial role in disorders and pathological cases…”
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Identification and pharmacological modification of resistance mechanisms to protoporphyrin-mediated photodynamic therapy in human cutaneous squamous cell carcinoma cell lines by Schary, Nicole, Novak, Ben, Kämper, Laura, Yousf, Aisha, Lübbert, Hermann

“…•Resistance to ALA-PDT in squamous cell carcinoma cells is associated with a conserved threshold of protoporphyrin IX accumulation.•Cutaneous SCC cell lines…”
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Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C) by Engels, Peter, Sullivan, Michael, Müller, Thomas, Lübbert, Hermann

“…We have recently reported increased survival of dopaminergic substantia nigra neurons by inhibition of phosphodiesterase type IV enzymes. As a first step to…”
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Loss of parkin causes endoplasmic reticulum calcium dyshomeostasis by upregulation of reticulocalbin 1 by Rybarski, Max, Mrohs, David, Osenberg, Katharina, Hemmersbach, Maren, Pfeffel, Katharina, Steinkamp, Joy, Schmidt, David, Violou, Karina, Schäning, Ruth, Schmidtke, Katja, Bader, Verian, Andriske, Michael, Bohne, Pauline, Mark, Melanie D., Winklhofer, Konstanze F., Lübbert, Hermann, Zhu, Xin‐Ran

“…Increasing evidence suggests that astrocytes play an important role in the progression of Parkinson's disease (PD). Previous studies on our parkin knockout…”
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Synaptic adhesion molecules in Cadm family at the neuromuscular junction by Tanabe, Yuko, Fujita, Eriko, Hayashi, Yukiko K., Zhu, Xinran, Lubbert, Hermann, Mezaki, Yoshihiro, Senoo, Haruki, Momoi, Takashi

“…RA175/SynCAM1/Cadm1 (Cadm1), a member of the immunoglobulin superfamily, is a synaptic cell adhesion molecule that has a PDZ‐binding motif at the C‐terminal…”
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