Search Results - "L, Munn"

Physical traits of cancer by Nia, Hadi T., Munn, Lance L., Jain, Rakesh K.

“…The biological and physical properties of tumors contribute to their growth and to treatment outcome. Although intense research efforts have helped to…”
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Cancer and inflammation by Munn, Lance L.

“…The relationship between inflammation and cancer has been recognized since the 17th century,1 and we now know much about the cells, cytokines and physiological…”
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Fluid forces control endothelial sprouting by Song, Jonathan W., Munn, Lance L.

“…During angiogenesis, endothelial cells (ECs) from intact blood vessels quickly infiltrate avascular regions via vascular sprouting. This process is fundamental…”
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Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside by Stylianopoulos, Triantafyllos, Munn, Lance L, Jain, Rakesh K

“…Physical forces have a crucial role in tumor progression and cancer treatment. The application of principles of engineering and physical sciences to oncology…”
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Combining microenvironment normalization strategies to improve cancer immunotherapy by Mpekris, Fotios, Voutouri, Chrysovalantis, Baish, James W., Duda, Dan G., Munn, Lance L., Stylianopoulos, Triantafyllos, Jain, Rakesh K.

“…Advances in immunotherapy have revolutionized the treatment of multiple cancers. Unfortunately, tumors usually have impaired blood perfusion, which limits the…”
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Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells by Cheng, Gang, Tse, Janet, Jain, Rakesh K, Munn, Lance L

“…Compressive mechanical stress produced during growth in a confining matrix limits the size of tumor spheroids, but little is known about the dynamics of stress…”
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The Lymphatic System in Disease Processes and Cancer Progression by Padera, Timothy P, Meijer, Eelco F.J, Munn, Lance L

“…Advances in our understanding of the structure and function of the lymphatic system have made it possible to identify its role in a variety of disease…”
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Normalization of the vasculature for treatment of cancer and other diseases by Goel, Shom, Duda, Dan G, Xu, Lei, Munn, Lance L, Boucher, Yves, Fukumura, Dai, Jain, Rakesh K

“…New vessel formation (angiogenesis) is an essential physiological process for embryologic development, normal growth, and tissue repair. Angiogenesis is…”
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Computational simulations of tumor growth and treatment response: Benefits of high-frequency, low-dose drug regimens and concurrent vascular normalization by Nikmaneshi, Mohammad R, Jain, Rakesh K, Munn, Lance L

“…Implementation of effective cancer treatment strategies requires consideration of how the spatiotemporal heterogeneities within the tumor microenvironment…”
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Diffusion of Particles in the Extracellular Matrix: The Effect of Repulsive Electrostatic Interactions by Stylianopoulos, Triantafyllos, Poh, Ming-Zher, Insin, Numpon, Bawendi, Moungi G., Fukumura, Dai, Munn, Lance L., Jain, Rakesh K.

“…Diffusive transport of macromolecules and nanoparticles in charged fibrous media is of interest in many biological applications, including drug delivery and…”
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Mechanical compression drives cancer cells toward invasive phenotype by Tse, Janet M, Cheng, Gang, Tyrrell, James A, Wilcox-Adelman, Sarah A, Boucher, Yves, Jain, Rakesh K, Munn, Lance L

“…Uncontrolled growth in a confined space generates mechanical compressive stress within tumors, but little is known about how such stress affects tumor cell…”
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Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy by Huang, Yuhui, Yuan, Jianping, Righi, Elda, Kamoun, Walid S., Ancukiewicz, Marek, Nezivar, Jean, Santosuosso, Michael, Martin, John D., Martin, Margaret R., Vianello, Fabrizio, Leblanc, Pierre, Munn, Lance L., Huang, Peigen, Duda, Dan G., Fukumura, Dai, Jain, Rakesh K., Poznansky, Mark C.

“…The recent approval of a prostate cancer vaccine has renewed hope for anticancer immunotherapies. However, the immunosuppressive tumor microenvironment may…”
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Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis : Insights from a mathematical model by JAIN, Rakesh K, TONG, Ricky T, MUNN, Lance L

“…Preclinical and clinical evidence shows that antiangiogenic agents can decrease tumor vessel permeability and interstitial fluid pressure (IFP) in a process of…”
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Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors by Stylianopoulos, Triantafyllos, Martin, John D., Chauhan, Vikash P., Jain, Saloni R., Diop-Frimpong, Benjamin, Bardeesy, Nabeel, Smith, Barbara L., Ferrone, Cristina R., Hornicek, Francis J., Boucher, Yves, Munn, Lance L., Jain, Rakesh K.

“…The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models…”
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Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival by Kloepper, Jonas, Riedemann, Lars, Amoozgar, Zohreh, Seano, Giorgio, Susek, Katharina, Yu, Veronica, Dalvie, Nisha, Amelung, Robin L., Datta, Meenal, Song, Jonathan W., Askoxylakis, Vasileios, Taylor, Jennie W., Lu-Emerson, Christine, Batista, Ana, Kirkpatrick, Nathaniel D., Jung, Keehoon, Snuderl, Matija, Muzikansky, Alona, Stubenrauch, Kay G., Krieter, Oliver, Wakimoto, Hiroaki, Xu, Lei, Munn, Lance L., Duda, Dan G., Fukumura, Dai, Batchelor, Tracy T., Jain, Rakesh K.

“…Inhibition of the vascular endothelial growth factor (VEGF) pathway has failed to improve overall survival of patients with glioblastoma (GBM). We previously…”
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Determinants of leukocyte margination in rectangular microchannels by Jain, Abhishek, Munn, Lance L

“…Microfabrication of polydimethylsiloxane (PDMS) devices has provided a new set of tools for studying fluid dynamics of blood at the scale of real microvessels…”
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Mechanobiological oscillators control lymph flow by Kunert, Christian, Baish, James W., Liao, Shan, Padera, Timothy P., Munn, Lance L.

“…The ability of cells to sense and respond to physical forces has been recognized for decades, but researchers are only beginning to appreciate the fundamental…”
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The effects of gravity and compression on interstitial fluid transport in the lower limb by Baish, James W., Padera, Timothy P., Munn, Lance L.

“…Edema in the limbs can arise from pathologies such as elevated capillary pressures due to failure of venous valves, elevated capillary permeability from local…”
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The regulation of Endosomal Sorting Complex Required for Transport and accessory proteins in multivesicular body sorting and enveloped viral budding - An overview by Ahmed, Ishtiaq, Akram, Zain, Iqbal, Hafiz M.N., Munn, Alan L.

“…ESCRT (Endosomal Sorting Complex Required for Transport) machinery drives different cellular processes such as endosomal sorting, organelle biogenesis,…”
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Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy by Stylianopoulos, Triantafyllos, Munn, Lance L, Jain, Rakesh K

“…A solid tumor is like an aberrant organ - comprised of cancer cells and a variety of host cells embedded in an extracellular matrix - nourished by blood…”
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