Search Results - "Kyung-Sun Heo"

Cytokine‐induced apoptosis inhibitor 1 (CIAPIN1) accelerates vascular remodelling via p53 and JAK2‐STAT3 regulation in vascular smooth muscle cells by Han, Joo‐Hui, Heo, Kyung‐Sun, Myung, Chang‐Seon

“…Background and purpose Abnormal vascular smooth muscle cell (VSMC) proliferation and migration lead to neointima formation, which eventually results in…”
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Therapeutic targets for endothelial dysfunction in vascular diseases by Huynh, Diem Thi Ngoc, Heo, Kyung-Sun

“…Vascular endothelial cells are located on the surface of the blood vessels. It has been recognized as an important barrier to the regulation of vascular…”
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Ginsenoside-Rg2 exerts anti-cancer effects through ROS-mediated AMPK activation associated mitochondrial damage and oxidation in MCF-7 cells by Jeon, Hyesu, Jin, Yujin, Myung, Chang-Seon, Heo, Kyung-Sun

“…In this study, we investigated the anti-cancer effects of ginsenoside Rg2 (G-Rg2) and its underlying signaling pathways in breast cancer (BC) cells. G-Rg2…”
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Minor Ginsenoside Rg2 and Rh1 Attenuates LPS-Induced Acute Liver and Kidney Damages via Downregulating Activation of TLR4-STAT1 and Inflammatory Cytokine Production in Macrophages by Huynh, Diem Thi Ngoc, Baek, Naehwan, Sim, Sohyun, Myung, Chang-Seon, Heo, Kyung-Sun

“…Ginsenosides have been reported to have various biological effects, such as immune regulation and anticancer activity. In this study, we investigated the…”
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Ginsenoside Rh1 Prevents Migration and Invasion through Mitochondrial ROS-Mediated Inhibition of STAT3/NF-κB Signaling in MDA-MB-231 Cells by Jin, Yujin, Huynh, Diem Thi Ngoc, Myung, Chang-Seon, Heo, Kyung-Sun

“…Breast cancer (BC) a very common cancer in women worldwide. Triple negative breast cancer (TNBC) has been shown to have a poor prognosis with a high level of…”
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Potential biological functions and future perspectives of sialylated milk oligosaccharides by Nguyen, Thuy Le Lam, Nguyen, Dung Van, Heo, Kyung-Sun

“…Sialyllactoses (SLs) primarily include sialylated human milk oligosaccharides (HMOs) and bovine milk oligosaccharides (BMOs). First, the safety assessment of…”
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Protective effects of ginsenoside-Rg2 and -Rh1 on liver function through inhibiting TAK1 and STAT3-mediated inflammatory activity and Nrf2/ARE-mediated antioxidant signaling pathway by Nguyen, Thuy Le Lam, Huynh, Diem Thi Ngoc, Jin, Yujin, Jeon, Hyesu, Heo, Kyung-Sun

“…Systemic or hepatic inflammation is caused by intraperitoneal application of lipopolysaccharide (LPS). In this study, we investigated anti-inflammatory and…”
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Disturbed Flow-Induced Endothelial Proatherogenic Signaling Via Regulating Post-Translational Modifications and Epigenetic Events by Heo, Kyung-Sun, Berk, Bradford C, Abe, Jun-Ichi

“…Hemodynamic shear stress, the frictional force exerted onto the vascular endothelial cell (EC) surface, influences vascular EC functions. Atherosclerotic…”
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Cucurbitane Triterpenoids from the Fruits of Momordica Charantia Improve Insulin Sensitivity and Glucose Homeostasis in Streptozotocin‐Induced Diabetic Mice by Han, Joo‐Hui, Tuan, Nguyen Quoc, Park, Min‐Ho, Quan, Khong Trong, Oh, Joonseok, Heo, Kyung‐Sun, Na, MinKyun, Myung, Chang‐Seon

“…Scope Momordica charantia (M. charantia) has antidiabetic effects, and cucurbitane‐type triterpenoid is one of the compounds of M. charantia. This study aims…”
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Loss of PP4 contributes to diesel exhaust particles‐induced epithelial barrier integrity disruption and alarmins release by Yang, Feng‐Ming, Hu, Meng‐Chun, Weng, Chih‐Ming, Chuang, Hsiao‐Chi, Lan, Yu‐Ting, Su, Bing‐Hua, Heo, Kyung‐Sun, Kuo, Han‐Pin

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Ginsenoside Rh1 Induces MCF-7 Cell Apoptosis and Autophagic Cell Death through ROS-Mediated Akt Signaling by Huynh, Diem Thi Ngoc, Jin, Yujin, Myung, Chang-Seon, Heo, Kyung-Sun

“…Breast cancer (BC) is the leading cause of cancer-related deaths among women worldwide. Ginsenosides exhibit anticancer activity against various cancer cells…”
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Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling by Park, Hyun-Soo, Han, Joo-Hui, Park, Jeong Won, Lee, Do-Hyung, Jang, Keun-Woo, Lee, Miji, Heo, Kyung-Sun, Myung, Chang-Seon

“…Propionate is a short-chain fatty acid (SCFA) mainly produced from carbohydrates by gut microbiota. Sodium propionate (SP) has shown to suppress the invasion…”
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Human milk oligosaccharides 3′-sialyllactose and 6′-sialyllactose attenuate LPS-induced lung injury by inhibiting STAT1 and NF-κB signaling pathways by Jin, Yujin, Jeon, Hyesu, Le Lam Nguyen, Thuy, Kim, Lila, Heo, Kyung-Sun

“…Acute lung injury (ALI) is the leading cause of respiratory diseases induced by uncontrolled inflammation and cell death. Lipopolysaccharide (LPS) is a major…”
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ERK5 Activation in Macrophages Promotes Efferocytosis and Inhibits Atherosclerosis by HEO, Kyung-Sun, CUSHMAN, Hannah J, AKAIKE, Masashi, WOO, Chang-Hoon, XIN WANG, XING QIU, FUJIWARA, Keigi, ABE, Jun-Ichi

“…Efferocytosis is a process by which dead and dying cells are removed by phagocytic cells. Efferocytosis by macrophages is thought to curb the progression of…”
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Disturbed-Flow-Mediated Vascular Reactive Oxygen Species Induce Endothelial Dysfunction by Heo, Kyung-Sun, Fujiwara, Keigi, Abe, Jun-ichi

“…Emerging evidence is revealing the different roles of steady laminar flow (s-flow) and disturbed flow (d-flow) in the regulation of the vascular endothelium…”
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A Crucial Role for p90RSK-Mediated Reduction of ERK5 Transcriptional Activity in Endothelial Dysfunction and Atherosclerosis by LE, Nhat-Tu, HEO, Kyung-Sun, HAODONG XU, MORRELL, Craig, SULLIVAN, Mark A, COHEN, Michael S, SERAFIMOVA, Iana M, TAUNTON, Jack, FUJIWARA, Keigi, ABE, Jun-Ichi, TAKEI, Yuichiro, LEE, Hakjoo, WOO, Chang-Hoon, CHANG, Eugene, MCCLAIN, Carolyn, HURLEY, Cheryl, XIN WANG, FAQIAN LI

“…Diabetes mellitus is a major risk factor for cardiovascular mortality by increasing endothelial cell (EC) dysfunction and subsequently accelerating…”
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Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents by Le, Nhat-Tu, Takei, Yuichiro, Izawa-Ishizawa, Yuki, Heo, Kyung-Sun, Lee, Hakjoo, Smrcka, Alan V, Miller, Benjamin L, Ko, Kyung Ae, Ture, Sara, Morrell, Craig, Fujiwara, Keigi, Akaike, Masashi, Abe, Jun-ichi

“…Because ERK5 inhibits endothelial inflammation and dysfunction, activating ERK5 might be a novel approach to protecting vascular endothelial cells (ECs)…”
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Erratum to: Regulation of post-translational modification in breast cancer treatment by Heo, Kyung-Sun

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Experimental model and novel therapeutic targets for non-alcoholic fatty liver disease development by 진유진, 허경선

“…Non-alcoholic fatty liver disease (NAFLD) is a complex disorder characterized by the accumulation of fat in the liver in the absence of excessive alcohol…”
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Regulation of post-translational modification in breast cancer treatment by Heo, Kyung-Sun

“…The small ubiquitin-related modification molecule (SUMO), one of the post-translational modification molecules, is involved in a variety of cellular functions…”
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