Search Results - "Kyun-Seop Bae"

Randomised clinical trial: safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple oral doses of tegoprazan (CJ‐12420), a novel potassium‐competitive acid blocker, in healthy male subjects by Han, Sungpil, Choi, Hee Youn, Kim, Yo Han, Nam, Ji Yeon, Kim, Bongtae, Song, Geun Seog, Lim, Hyeong‐Seok, Bae, Kyun‐Seop

“…Summary Background Tegoprazan (CJ‐12420) is a potassium‐competitive acid blocker (P‐CAB) with therapeutic potential for gastro‐oesophageal reflux disease…”
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Likelihood interval for nonlinear regression by Lee, Moon Hee, Bae, Kyun-Seop

“…Wald confidence interval has been used as the conventional method of interval estimation for the parameters in nonlinear models. Because Wald confidence…”
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A Comparison of the Charlson and Elixhauser Methods for Predicting Nursing Indicators in Gastrectomy with Gastric Cancer Patients by Kim, Chul-Gyu, Bae, Kyun-Seop

“…Comorbidity indices such as Charlson's (CCI) and Elixhauser's (ECI) are used to adjust the patient's care, depending on the severity of their condition…”
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Quantitative Modeling Analysis Demonstrates the Impact of CYP2C19 and CYP2D6 Genetic Polymorphisms on the Pharmacokinetics of Amitriptyline and Its Metabolite, Nortriptyline by Koh, Ara, Pak, Kwan Cheol, Choi, Hee Youn, Ryu, Sunae, Choi, Seung‐eun, Kim, Ki Soon, Bae, Kyun‐Seop, Lim, Hyeong‐Seok

“…Amitriptyline is a tricyclic antidepressant that is metabolized mainly by CYP2C19 and CYP2D6 enzymes. Higher plasma levels of amitriptyline and its active…”
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Comparison of Pharmacodynamics between Tegoprazan and Dexlansoprazole Regarding Nocturnal Acid Breakthrough: A Randomized Crossover Study by Han, Sungpil, Choi, Hee Youn, Kim, Yo Han, Choi, SeungChan, Kim, Seokuee, Nam, Ji Yeon, Kim, Bongtae, Song, Geun Seog, Lim, Hyeong-Seok, Bae, Kyun-Seop

“…Tegoprazan, a novel potassium-competitive acid blocker, is expected to overcome the limitations of proton pump inhibitors and effectively control nocturnal…”
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Disease Progression Modeling Analysis of the Change of Bone Mineral Density by Postoperative Hormone Therapies in Postmenopausal Patients With Early Breast Cancer by Yoon, SeokKyu, Bae, Kyun‐Seop, Cho, Yong‐Soon, Han, Sunpil, Kim, Hyungsub, Lim, Hyeong‐Seok

“…The osteoporosis incidence in postmenopausal patients on aromatase inhibitors (AI) is much higher than in those on tamoxifen, and adverse effects other than…”
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Population pharmacokinetic and pharmacodynamic analysis of tremelimumab in patients with metastatic melanoma by Wang, Erjian, Kang, Dongwoo, Bae, Kyun-Seop, Marshall, Margaret A., Pavlov, Dmitri, Parivar, Kourosh

“…Tremelimumab, a fully human monoclonal antibody specific for human cytotoxic T‐lymphocyte‐associated antigen 4, has been studied in clinical trials. We have…”
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Pharmacokinetics of Hydroxychloroquine and Its Clinical Implications in Chemoprophylaxis against Malaria Caused by Plasmodium vivax by LIM, Hyeong-Seok, IM, Jeong-Soo, CHO, Joo-Youn, BAE, Kyun-Seop, KLEIN, Terry A, YEOM, Joon-Sup, KIM, Tae-Seon, CHOI, Jae-Seon, JANG, In-Jin, PARK, Jae-Won

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A Phase I/IIa Study of DHP107, a Novel Oral Paclitaxel Formulation, in Patients with Advanced Solid Tumors or Gastric Cancer by Ryu, Min‐Hee, Ryoo, Baek‐Yeol, Kim, Tae Won, Kim, Sung Bae, Lim, Hyeong‐Seok, Bae, Kyun‐Seop, Park, Sook Ryun, Jo, Yeong‐Woo, Cho, Hyun Ju, Kang, Yoon‐Koo

“…Lessons Learned Ideally, patients should have access to an oral formulation of paclitaxel, as well as an intravenous formulation, to allow development of…”
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Impact of CYP2D6, CYP3A5, CYP2C19, CYP2A6, SLCO1B1, ABCB1, and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin acid by Choi, Hee Youn, Bae, Kyun-Seop, Cho, Sang-Heon, Ghim, Jong-Lyul, Choe, Sangmin, Jung, Jin Ah, Jin, Seok-Joon, Kim, Hee-Sun, Lim, Hyeong-Seok

“…OBJECTIVEThe effects of various polymorphisms in cytochrome P450 (CYP) enzyme and transporter genes on the pharmacokinetics (PK) of simvastatin were evaluated…”
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Effects of Renal Impairment on the Pharmacokinetics and Safety of Udenafil by Cho, Yong‐Soon, Noh, Yook‐Hwan, Lim, Hyeong‐Seok, Cho, Sang‐Heon, Ghim, Jong‐Lyul, Choe, Sangmin, Kim, Soon‐Bae, Park, Jung‐Sik, Lee, Sang‐Koo, Yang, Won‐Seok, Chang, Jai‐Won, Bahng, Mi‐Young, Bae, Kyun‐Seop

“…Udenafil is a phosphodiesterase‐5 inhibitor used to treat erectile dysfunction. Although udenafil is not predominantly eliminated by the kidney, renal…”
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Pharmacokinetic Evaluation by Modeling and Simulation Analysis of a Donepezil Patch Formulation in Healthy Male Volunteers by Yoon, Seok Kyu, Bae, Kyun-Seop, Hong, Dong Hyun, Kim, Seong Su, Choi, Young Kweon, Lim, Hyeong-Seok

“…This study characterized the pharmacokinetics (PKs) of a donepezil patch formulation currently under development, using mixed effect modeling analysis, and…”
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A Simulation Study to Compare the Treatment Effect of Tamoxifen by CYP2D6 Genotypes and Third‐Generation Aromatase Inhibitors by Pak, Kwan Cheol, Jung, Jin‐A, Bae, Kyun‐Seop, Lim, Hyeong‐Seok

“…Some prospective, randomized clinical trials, including ATAC and BIG 1–98, demonstrated superior treatment effect of third‐generation aromatase inhibitors…”
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Modeling and simulation analysis of the relationship between lesion recurrence on brain images and clinical recurrence in patients with ischemic stroke by Lim, Hyeong-Seok, Bae, Kyun-Seop

“…The objective of current study is to assess the relationship between characteristics of patients with acute ischemic stroke and clinical recurrences to…”
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Population plasma and urine pharmacokinetics of ivabradine and its active metabolite S18982 in healthy Korean volunteers by Choi, Hee Youn, Bae, Kyun-Seop, Cho, Sang-Heon, Ghim, Jong-Lyul, Choe, Sangmin, Jung, Jin Ah, Lim, Hyeong-Seok

“…Ivabradine, a selective inhibitor of the pacemaker current (If), is used for heart failure and coronary heart disease and is mainly metabolized to S18982. The…”
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A simple time-to-event model with NONMEM featuring right-censoring by Tran, Quyen Thi, Chae, Jung-woo, Bae, Kyun-Seop, Yun, Hwi-yeol

“…In healthcare situations, time-to-event (TTE) data are common outcomes. A parametric approach is often employed to handle TTE data because it is possible to…”
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Pharmacokinetics and Pharmacodynamics of Ticagrelor and Prasugrel in Healthy Male Korean Volunteers by Jeon, Hae-Sun, MD, Kim, Mi-Jo, MD, PhD, Choi, Hee-Youn, MD, Kim, Yo-Han, MD, Kim, Eun-Hwa, BS, Kim, A-Reum, MS, Park, Hyun-Jung, BS, Bae, Kyun-Seop, MD, PhD, Lim, Hyeong-Seok, MD, PhD

“…Abstract Purpose A combination of clopidogrel and aspirin is the standard treatment for patients with acute coronary syndrome and those undergoing percutaneous…”
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Tolerability and pharmacokinetics of avanafil, a phosphodiesterase type 5 inhibitor: A single- and multiple-dose, double-blind, randomized, placebo-controlled, dose-escalation study in healthy Korean male volunteers by Jung, Jinah, MD, Choi, Sangmin, MD, PhD, Cho, Sang Heon, MD, PhD, Ghim, Jong-Lyul, MD, PhD, Hwang, Aekyung, MS, Kim, Unjib, MD, Kim, Bong Sik, MD, Koguchi, Atsushi, DVM, PhD, Miyoshi, Shinji, MS, Okabe, Hirotaka, MS, Bae, Kyun-Seop, MD, PhD, Lim, Hyeong-Seok, MD, PhD

“…Abstract Background: Avanafil is a selective phosphodiesterase type 5 inhibitor being developed for the treatment of erectile dysfunction. Objective: This…”
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Comparison of Pharmacodynamics between Tegoprazan and Dexlansoprazole Regarding Nocturnal Acid Breakthrough: A Randomized Crossover Study by Sungpil Han, Hee Youn Choi, Yo Han Kim, Seungchan Choi, Seokuee Kim, Ji Yeon Nam, Bongtae Kim, Geun Seog Song, Hyeong-seok Lim, Kyun-seop Bae

“…Background/Aims: Tegoprazan, a novel potassium-competitive acid blocker, is expected to overcome the limitations of proton pump inhibitors and effectively…”
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Comparison of Pharmacodynamics between Tegoprazan and Dexlansoprazole Regarding Nocturnal Acid Breakthrough: A Randomized Crossover Study by Sungpil Han, Hee Youn Choi, Yo Han Kim, Seungchan Choi, Seokuee Kim, Ji Yeon Nam, Bongtae Kim, Geun Seog Song, Hyeong-seok Lim, Kyun-seop Bae

“…Background/Aims: Tegoprazan, a novel potassium-competitive acid blocker, is expected to overcome the limitations of proton pump inhibitors and effectively…”
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