Search Results - "Kyu, Shuya"

Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19 by Woodruff, Matthew C., Ramonell, Richard P., Nguyen, Doan C., Cashman, Kevin S., Saini, Ankur Singh, Haddad, Natalie S., Ley, Ariel M., Kyu, Shuya, Howell, J. Christina, Ozturk, Tugba, Lee, Saeyun, Suryadevara, Naveenchandra, Case, James Brett, Bugrovsky, Regina, Chen, Weirong, Estrada, Jacob, Morrison-Porter, Andrea, Derrico, Andrew, Anam, Fabliha A., Sharma, Monika, Wu, Henry M., Le, Sang N., Jenks, Scott A., Tipton, Christopher M., Staitieh, Bashar, Daiss, John L., Ghosn, Eliver, Diamond, Michael S., Carnahan, Robert H., Crowe, James E., Hu, William T., Lee, F. Eun-Hyung, Sanz, Ignacio

“…A wide spectrum of clinical manifestations has become a hallmark of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic,…”
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Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion by Nguyen, Doan C., Garimalla, Swetha, Xiao, Haopeng, Kyu, Shuya, Albizua, Igor, Galipeau, Jacques, Chiang, Kuang-Yueh, Waller, Edmund K., Wu, Ronghu, Gibson, Greg, Roberson, James, Lund, Frances E., Randall, Troy D., Sanz, Iñaki, Lee, F. Eun-Hyung

“…Human antibody-secreting cells (ASC) in peripheral blood are found after vaccination or infection but rapidly apoptose unless they migrate to the bone marrow…”
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Human rhinovirus induced cytokine/chemokine responses in human airway epithelial and immune cells by Rajan, Devi, McCracken, Courtney E, Kopleman, Hannah B, Kyu, Shuya Y, Lee, F Eun-Hyung, Lu, Xiaoyan, Anderson, Larry J

“…Infections with human rhinovirus (HRV) are commonly associated with acute upper and lower respiratory tract disease and asthma exacerbations. The role that…”
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Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus by Chen, Weirong, Hong, So-Hee, Jenks, Scott A., Anam, Fabliha A., Tipton, Christopher M., Woodruff, Matthew C., Hom, Jennifer R., Cashman, Kevin S., Faliti, Caterina Elisa, Wang, Xiaoqian, Kyu, Shuya, Wei, Chungwen, Scharer, Christopher D., Mi, Tian, Hicks, Sakeenah, Hartson, Louise, Nguyen, Doan C., Khosroshahi, Arezou, Lee, Saeyun, Wang, Youliang, Bugrovsky, Regina, Ishii, Yusho, Lee, F. Eun-Hyung, Sanz, Ignacio

“…Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple autoantibody types, some of which are produced by long-lived plasma cells…”
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Diagnosis of Streptococcus pneumoniae infection using circulating antibody secreting cells by Kyu, Shuya, Ramonell, Richard P, Kuruvilla, Merin, Kraft, Colleen S, Wang, Yun F, Falsey, Ann R, Walsh, Edward E, Daiss, John L, Paulos, Simon, Rajam, Gowrisankar, Wu, Hao, Velusamy, Srinivasan, Lee, F Eun-Hyung

“…Streptococcus pneumoniae infections cause morbidity and mortality worldwide. A rapid, simple diagnostic method could reduce the time needed to introduce…”
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Author Correction: Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion by Nguyen, Doan C., Garimalla, Swetha, Xiao, Haopeng, Kyu, Shuya, Albizua, Igor, Galipeau, Jacques, Chiang, Kuang-Yueh, Waller, Edmund K., Wu, Ronghu, Gibson, Greg, Roberson, James, Lund, Frances E., Randall, Troy D., Sanz, Iñaki, Lee, F. Eun-Hyung

“…The original version of this Article omitted a declaration from the Competing Interests statement, which should have included the following: ‘A patent has been…”
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Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cells by Kyu, Shuya Y., Kobie, James, Yang, Hongmei, Zand, Martin S., Topham, David J., Quataert, Sally A., Sanz, Ignacio, Lee, F. Eun-Hyung

“…The rise in influenza-specific neutralizing antibody levels is proceeded by a burst of antigen-specific antibody secreting cells (ASC) or plasmablasts…”
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Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow by Halliley, Jessica L, Tipton, Christopher M, Liesveld, Jane, Rosenberg, Alexander F, Darce, Jaime, Gregoretti, Ivan V, Popova, Lana, Kaminiski, Denise, Fucile, Christopher F, Albizua, Igor, Kyu, Shuya, Chiang, Kuang-Yueh, Bradley, Kyle T, Burack, Richard, Slifka, Mark, Hammarlund, Erika, Wu, Hao, Zhao, Liping, Walsh, Edward E, Falsey, Ann R, Randall, Troy D, Cheung, Wan Cheung, Sanz, Iñaki, Lee, F Eun-Hyung

“…Antibody responses to viral infections are sustained for decades by long-lived plasma cells (LLPCs). However, LLPCs have yet to be characterized in humans…”
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Dysregulated naive B cells and de novo autoreactivity in severe COVID-19 by Woodruff, Matthew C., Ramonell, Richard P., Haddad, Natalie S., Anam, Fabliha A., Rudolph, Mark E., Walker, Tiffany A., Truong, Alexander D., Dixit, Adviteeya N., Han, Jenny E., Cabrera-Mora, Monica, Runnstrom, Martin C., Bugrovsky, Regina, Hom, Jennifer, Connolly, Erin C., Albizua, Igor, Javia, Vidhi, Cashman, Kevin S., Nguyen, Doan C., Kyu, Shuya, Singh Saini, Ankur, Piazza, Michael, Tipton, Christopher M., Khosroshahi, Arezou, Gibson, Greg, Martin, Greg S., Maier, Cheryl L., Esper, Annette, Jenks, Scott A., Lee, F. Eun-Hyung, Sanz, Ignacio

“…Severe SARS-CoV-2 infection 1 has been associated with highly inflammatory immune activation since the earliest days of the COVID-19 pandemic 2 – 5 . More…”
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Patients on benralizumab, dupilumab, or mepolizumab have lower post-vaccination SARS-CoV-2 immunity by Runnstrom, Martin C., Lamothe, Pedro A., Faliti, Caterina E., Cheedarla, Narayanaiah, Moreno, Alberto, Suthar, Mehul S., Nahata, Rishika, Ravindran, Mayuran, Haddad, Natalie S., Morrison-Porter, Andrea, Quehl, Hannah, Ramonell, Richard P., Woodruff, Matthew, Anam, Fabliha, Zhang, Rebeca, Swenson, Colin, Polito, Carmen, Neveu, Wendy, Patel, Rahulkumar, Smirnova, Natalia, Kim, Caroline, Hentenaar, Ian, Kyu, Shuya, Usman, Sabeena, Ngo, Thuy, Guo, Zhenxing, Wu, Hao, Daiss, John L., Park, Jiwon, Manning, Kelly E, Wali, Bursha, Ellis, Madison L., Sharma, Sunita, Holguin, Fernando, Cheedarla, Suneethamma, Neish, Andrew S., Roback, John D., Sanz, Ignacio, Lee, F. Eun-Hyung

“…In a prospective observational study, patients with asthma or atopic dermatitis treated with benralizumab, dupilumab, or mepolizumab exhibited lower…”
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Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE by Faliti, Caterina E., Van, Trinh T. P., Anam, Fabliha A., Cheedarla, Narayanaiah, Williams, M. Elliott, Mishra, Ashish Kumar, Usman, Sabeena Y., Woodruff, Matthew C., Kraker, Geoff, Runnstrom, Martin C., Kyu, Shuya, Sanz, Daniel, Ahmed, Hasan, Ghimire, Midushi, Morrison-Porter, Andrea, Quehl, Hannah, Haddad, Natalie S., Chen, Weirong, Cheedarla, Suneethamma, Neish, Andrew S., Roback, John D., Antia, Rustom, Hom, Jennifer, Tipton, Christopher M., Lindner, John M., Ghosn, Eliver, Khurana, Surender, Scharer, Christopher D., Khosroshahi, Arezou, Lee, F. Eun-Hyung, Sanz, Ignacio

“…Severe acute respiratory syndrome coronavirus 2 mRNA vaccination has reduced effectiveness in certain immunocompromised individuals. However, the cellular…”
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Patients taking benralizumab, dupilumab, or mepolizumab have lower postvaccination SARS-CoV-2 immunity by Runnstrom, Martin C., Lamothe, Pedro A., Faliti, Caterina E., Cheedarla, Narayanaiah, Moreno, Alberto, Suthar, Mehul S., Nahata, Rishika, Ravindran, Mayuran, Haddad, Natalie S., Morrison-Porter, Andrea, Quehl, Hannah, Ramonell, Richard P., Woodruff, Matthew, Anam, Fabliha, Zhang, Rebeca, Swenson, Colin, Polito, Carmen, Neveu, Wendy, Patel, Rahulkumar, Smirnova, Natalia, Nguyen, Doan C., Kim, Caroline, Hentenaar, Ian, Kyu, Shuya, Usman, Sabeena, Ngo, Thuy, Guo, Zhenxing, Wu, Hao, Daiss, John L., Park, Jiwon, Manning, Kelly E., Wali, Bursha, Ellis, Madison L., Sharma, Sunita, Holguin, Fernando, Cheedarla, Suneethamma, Neish, Andrew S., Roback, John D., Sanz, Ignacio, Eun-Hyung Lee, F.

“…Biologic therapies inhibiting the IL-4 or IL-5 pathways are very effective in the treatment of asthma and other related conditions. However, the cytokines IL-4…”
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Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype by Ramonell, Richard P., Brown, Margaret, Woodruff, Matthew C., Levy, Joshua M., Wise, Sarah K., DelGaudio, John, Duan, Meixue, Saney, Celia L., Kyu, Shuya, Cashman, Kevin S., Hom, Jennifer R., Fucile, Christopher F., Rosenberg, Alexander F., Tipton, Christopher M., Sanz, Ignacio, Gibson, Gregory C., Lee, F. Eun-Hyung

“…Immunoglobulin (Ig) E is central to the pathogenesis of allergic conditions, including allergic fungal rhinosinusitis. However, little is known about IgE…”
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Humoral immunity prevents clinical malaria during Plasmodium relapses without eliminating gametocytes by Joyner, Chester J, Brito, Cristiana F A, Saney, Celia L, Joice Cordy, Regina, Smith, Maren L, Lapp, Stacey A, Cabrera-Mora, Monica, Kyu, Shuya, Lackman, Nicolas, Nural, Mustafa V, DeBarry, Jeremy D, Kissinger, Jessica C, Styczynski, Mark P, Lee, F Eun-Hyung, Lamb, Tracey J, Galinski, Mary R

“…Plasmodium relapses are attributed to the activation of dormant liver-stage parasites and are responsible for a significant number of recurring malaria…”
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Peak frequencies of circulating human influenza-specific antibody secreting cells correlate with serum antibody response after immunization by Halliley, Jessica L, Kyu, Shuya, Kobie, James J, Walsh, Edward E, Falsey, Ann R, Randall, Troy D, Treanor, John, Feng, Changyong, Sanz, Ignacio, Lee, F. Eun-Hyung

“…Abstract Upon vaccination, B cells differentiate into antibody secreting cells (ASCs) that migrate via the circulation to tissues. The kinetics of this…”
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Heterofunctional Particles as Single Cell Sensors to Capture Secreted Immunoglobulins and Isolate Antigen‐Specific Antibody Secreting Cells by Ramirez, Katily, Kyu, Shuya, Nguyen, Doan, Han, So‐Yun, Lee, Ye Lim, Bradley, John, Randall, Troy, Sanz, Ignacio, Lee, Frances Eun‐Hyung, Sulchek, Todd

“…Isolating cells based on their secreted proteins remain a challenge. The authors demonstrate a capacity for high throughput single‐cell protein secretion…”
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Differential transcriptome and development of human peripheral plasma cell subsets by Garimalla, Swetha, Nguyen, Doan C, Halliley, Jessica L, Tipton, Christopher, Rosenberg, Alexander F, Fucile, Christopher F, Saney, Celia L, Kyu, Shuya, Kaminski, Denise, Qian, Yu, Scheuermann, Richard H, Gibson, Greg, Sanz, Iñaki, Lee, F Eun-Hyung

“…Human antibody-secreting cells (ASCs) triggered by immunization are globally recognized as CD19loCD38hiCD27hi. Yet, different vaccines give rise to antibody…”
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One-Stop Serum Assay Identifies COVID-19 Disease Severity and Vaccination Responses by Haddad, Natalie S, Nguyen, Doan C, Kuruvilla, Merin E, Morrison-Porter, Andrea, Anam, Fabliha, Cashman, Kevin S, Ramonell, Richard P, Kyu, Shuya, Saini, Ankur Singh, Cabrera-Mora, Monica, Derrico, Andrew, Alter, David, Roback, John D, Horwath, Michael, O'Keefe, James B, Wu, Henry M, Wong, An-Kwok Ian, Dretler, Alexandra W, Gripaldo, Ria, Lane, Andrea N, Wu, Hao, Chu, Helen Y, Lee, Saeyun, Hernandez, Mindy, Engineer, Vanessa, Varghese, John, Patel, Rahul, Jalal, Anum, French, Victoria, Guysenov, Ilya, Lane, Christopher E, Mengistsu, Tesfaye, Normile, Katherine Elizabeth, Mnzava, Onike, Le, Sang, Sanz, Ignacio, Daiss, John L, Lee, F Eun-Hyung

“…SARS-CoV-2 has caused over 100,000,000 cases and almost 2,500,000 deaths globally. Comprehensive assessment of the multifaceted antiviral Ab response is…”
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Diagnosis of Streptococcus pneumoniae infection using circulating antibody secreting cells by Shuya Kyu, Richard P Ramonell, Merin Kuruvilla, Colleen S Kraft, Yun F Wang, Ann R Falsey, Edward E Walsh, John L Daiss, Simon Paulos, Gowrisankar Rajam, Hao Wu, Srinivasan Velusamy, F Eun-Hyung Lee

“…BackgroundStreptococcus pneumoniae infections cause morbidity and mortality worldwide. A rapid, simple diagnostic method could reduce the time needed to…”
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Novel Diagnostic for Streptococcus pneumoniae Infection Using Circulating Antigen-Specific Antibody-Secreting Cells by Kyu, Shuya Y., Kraft, Colleen, Wang, Yun F., Falsey, Ann R., Walsh, Edward, Daiss, John L., Rajam, Gowrisankar, Srinivasan, Velusamy, Ros, Sonia, Ades, Edwin, Lee, Frances Eun-Hyung

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