Search Results - "Kytölä, Soili"

Clonal dynamics using droplet digital polymerase chain reaction in peripheral blood predicts treatment responses in myelodysplastic syndrome by Illman, Johanna, Kytölä, Soili, Myllymäki, Mikko, Ebeling, Freja

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Detection of KRAS mutations in liquid biopsies from metastatic colorectal cancer patients using droplet digital PCR, Idylla, and next generation sequencing by Holm, Matilda, Andersson, Emma, Osterlund, Emerik, Ovissi, Ali, Soveri, Leena-Maija, Anttonen, Anna-Kaisa, Kytölä, Soili, Aittomäki, Kristiina, Osterlund, Pia, Ristimäki, Ari

“…Circulating tumor DNA (ctDNA) is released from cancer cells and oncogenic mutations in ctDNA can be measured from plasma samples. Droplet digital PCR (ddPCR)…”
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Characterization of p190-Bcr-Abl chronic myeloid leukemia reveals specific signaling pathways and therapeutic targets by Adnan-Awad, Shady, Kim, Daehong, Hohtari, Helena, Javarappa, Komal Kumar, Brandstoetter, Tania, Mayer, Isabella, Potdar, Swapnil, Heckman, Caroline A., Kytölä, Soili, Porkka, Kimmo, Doma, Eszter, Sexl, Veronika, Kankainen, Matti, Mustjoki, Satu

“…The oncogenic protein Bcr-Abl has two major isoforms, p190 Bcr-Abl and p210 Bcr-Abl . While p210 Bcr-Abl is the hallmark of chronic myeloid leukemia (CML),…”
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Detection of microsatellite instability with Idylla MSI assay in colorectal and endometrial cancer by Ukkola, Iiris, Nummela, Pirjo, Pasanen, Annukka, Kero, Mia, Lepistö, Anna, Kytölä, Soili, Bützow, Ralf, Ristimäki, Ari

“…Universal testing of microsatellite instability (MSI) is recommended for colorectal cancer (CRC) and endometrial cancer (EC) to screen for Lynch syndrome and…”
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Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia by Savola, Paula, Brück, Oscar, Olson, Thomas, Kelkka, Tiina, Kauppi, Markku J, Kovanen, Panu E, Kytölä, Soili, Sokka-Isler, Tuulikki, Loughran, Thomas P, Leirisalo-Repo, Marjatta, Mustjoki, Satu

“…Felty syndrome is a rare disease defined by neutropenia, splenomegaly, and rheumatoid arthritis. Sometimes the differential diagnosis between Felty syndrome…”
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Gene fusions and oncogenic mutations in MLH1 deficient and BRAFV600E wild-type colorectal cancers by Ukkola, Iiris, Nummela, Pirjo, Kero, Mia, Tammio, Hanna, Tuominen, Jenni, Kairisto, Veli, Kallajoki, Markku, Haglund, Caj, Peltomäki, Päivi, Kytölä, Soili, Ristimäki, Ari

“…Gene fusions can act as oncogenic drivers and offer targets for cancer therapy. Since fusions are rare in colorectal cancer (CRC), their universal screening…”
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Altered linkage pattern of N-glycan sialic acids in pseudomyxoma peritonei by Nummela, Pirjo, Heiskanen, Annamari, Kytölä, Soili, Haglund, Caj, Lepistö, Anna, Satomaa, Tero, Ristimäki, Ari

“…Abstract Pseudomyxoma peritonei (PMP) is a highly mucinous adenocarcinoma growing in the peritoneal cavity and most commonly originating from the appendix…”
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Sequential high-sensitivity mutational and chimerism analyses predict responses to post-transplant salvage therapies in MDS by Ebeling, Freja, Illman, Johanna, Kankainen, Matti, Kontro, Mika, Partanen, Anu, Sahlstedt, Leila, Myllymäki, Mikko, Niittyvuopio, Riitta, Kytölä, Soili

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Epigenetic modifier gene mutations in chronic myeloid leukemia (CML) at diagnosis are associated with risk of relapse upon treatment discontinuation by Adnan Awad, Shady, Brück, Oscar, Shanmuganathan, Naranie, Jarvinen, Timo, Lähteenmäki, Hanna, Klievink, Jay, Ibrahim, Hazem, Kytölä, Soili, Koskenvesa, Perttu, Hughes, Timothy P., Branford, Susan, Kankainen, Matti, Mustjoki, Satu

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ERCC6L2 defines a novel entity within inherited acute myeloid leukemia by Douglas, Suvi P.M., Siipola, Pihla, Kovanen, Panu E., Pyörälä, Marja, Kakko, Sakari, Savolainen, Eeva-Riitta, Salmenniemi, Urpu, Orte, Katri, Kytölä, Soili, Pitkänen, Esa, Porkka, Kimmo, Kilpivaara, Outi, Wartiovaara-Kautto, Ulla

“…Abstract There is a Blood Commentary on this article in this issue…”
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Prospective immunohistochemical analysis of BRAF V600E mutation in melanoma by Thiel, Alexandra, PhD, Moza, Monica, MD, PhD, Kytölä, Soili, PhD, Orpana, Arto, PhD, Jahkola, Tiina, MD, PhD, Hernberg, Micaela, MD, PhD, Virolainen, Susanna, MD, PhD, Ristimäki, Ari, MD, PhD

“…Summary The v-raf murine sarcoma viral oncogene homolog B1 ( BRAF ) V600E mutation is the most common activating genetic alteration of this oncogene and a…”
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Mutation accumulation in cancer genes relates to nonoptimal outcome in chronic myeloid leukemia by Adnan Awad, Shady, Kankainen, Matti, Ojala, Teija, Koskenvesa, Perttu, Eldfors, Samuli, Ghimire, Bishwa, Kumar, Ashwini, Kytölä, Soili, Kamel, Mahmoud M., Heckman, Caroline A., Porkka, Kimmo, Mustjoki, Satu

“…Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm accounting for ∼15% of all leukemia. Progress of the disease from an indolent chronic phase to…”
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BRAF mutation in sporadic colorectal cancer and Lynch syndrome by Thiel, Alexandra, Heinonen, Mira, Kantonen, Jonas, Gylling, Annette, Lahtinen, Laura, Korhonen, Mari, Kytölä, Soili, Mecklin, Jukka-Pekka, Orpana, Arto, Peltomäki, Päivi, Ristimäki, Ari

“…The aim of the study was to detect mutations of BRAF oncogene in colorectal cancer and to use this information to identify Lynch syndrome patients. Consecutive…”
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Somatic mutations and T-cell clonality in patients with immunodeficiency by Savola, Paula, Martelius, Timi, Kankainen, Matti, Huuhtanen, Jani, Lundgren, Sofie, Koski, Yrjö, Eldfors, Samuli, Kelkka, Tiina, Keränen, Mikko A I, Ellonen, Pekka, Kovanen, Panu E, Kytölä, Soili, Saarela, Janna, Lähdesmäki, Harri, Seppänen, Mikko R J, Mustjoki, Satu

“…Common variable immunodeficiency and other late-onset immunodeficiencies often co-manifest with autoimmunity and lymphoproliferation. The pathogenesis of most…”
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Patient-Specific Measurable Residual Disease Markers Predict Outcome in Patients With Myelodysplastic Syndrome and Related Diseases After Hematopoietic Stem-Cell Transplantation by Tobiasson, Magnus, Pandzic, Tatjana, Illman, Johanna, Nilsson, Lars, Weström, Simone, Ejerblad, Elisabeth, Olesen, Gitte, Björklund, Andreas, Olsnes Kittang, Astrid, Werlenius, Olle, Lorentz, Fryderyk, Rasmussen, Bengt, Cammenga, Jörg, Weber, Duruta, Lindholm, Carolin, Wiggh, Joel, Dimitriou, Marios, Moen, Ann Elin, Yip Lundström, Laimei, von Bahr, Lena, Baltzer-Sollander, Karin, Jädersten, Martin, Kytölä, Soili, Walldin, Gunilla, Ljungman, Per, Groenbaek, Kirsten, Mielke, Stephan, Jacobsen, Sten Eirik W, Ebeling, Freja, Cavelier, Lucia, Smidstrup Friis, Lone, Dybedal, Ingunn, Hellström-Lindberg, Eva

“…Clinical relapse is the major threat for patients with myelodysplastic syndrome (MDS) undergoing hematopoietic stem-cell transplantation (HSCT). Early…”
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Atypical (non‐V600E) BRAF mutations in metastatic colorectal cancer in population and real‐world cohorts by Osterlund, Emerik, Ristimäki, Ari, Mäkinen, Markus J., Kytölä, Soili, Kononen, Juha, Pfeiffer, Per, Soveri, Leena‐Maija, Keinänen, Mauri, Sorbye, Halfdan, Nunes, Luís, Salminen, Tapio, Nieminen, Lasse, Uutela, Aki, Halonen, Päivi, Ålgars, Annika, Sundström, Jari, Kallio, Raija, Ristamäki, Raija, Lamminmäki, Annamarja, Stedt, Hanna, Heervä, Eetu, Kuopio, Teijo, Sjöblom, Tobias, Isoniemi, Helena, Glimelius, Bengt, Osterlund, Pia

“…BRAF‐V600E mutation (mt) is a strong negative prognostic and predictive biomarker in metastatic colorectal cancer (mCRC). Non‐V600Emt, designated atypical…”
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Somatic mutations and T-cell clonality in patients with immunodeficiency by Savola, Paula, Martelius, Timi, Kankainen, Matti, Huuhtanen, Jani, Lundgren, Sofie, Koski, Yrjö, Eldfors, Samuli, Kelkka, Tiina, Keränen, Mikko A I, Ellonen, Pekka, Kovanen, Panu E, Kytölä, Soili, Saarela, Janna, Lähdesmäki, Harri, Seppänen, Mikko R J, Mustjoki, Satu

“…Common variable immunodeficiency and other late-onset immunodeficiencies often co-manifest with autoimmunity and lymphoproliferation. The pathogenesis of most…”
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EGFR gene copy number predicts response to anti‐EGFR treatment in RAS wild type and RAS/BRAF/PIK3CA wild type metastatic colorectal cancer by Ålgars, Annika, Sundström, Jari, Lintunen, Minnamaija, Jokilehto, Terhi, Kytölä, Soili, Kaare, Milja, Vainionpää, Reetta, Orpana, Arto, Österlund, Pia, Ristimäki, Ari, Carpen, Olli, Ristamäki, Raija

“…Anti‐EGFR antibodies are used for the treatment of RAS wild type metastatic colorectal cancer. We previously showed that EGFR gene copy number (GCN) predicts…”
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Resectability, conversion, metastasectomy and outcome according to RAS and BRAF status for metastatic colorectal cancer in the prospective RAXO study by Uutela, Aki, Osterlund, Emerik, Halonen, Päivi, Kallio, Raija, Ålgars, Annika, Salminen, Tapio, Lamminmäki, Annamarja, Soveri, Leena-Maija, Ristamäki, Raija, Lehtomäki, Kaisa, Stedt, Hanna, Heervä, Eetu, Muhonen, Timo, Kononen, Juha, Nordin, Arno, Ovissi, Ali, Kytölä, Soili, Keinänen, Mauri, Sundström, Jari, Nieminen, Lasse, Mäkinen, Markus J., Kuopio, Teijo, Ristimäki, Ari, Isoniemi, Helena, Osterlund, Pia

“…Background Outcomes after metastasectomy for metastatic colorectal cancer (mCRC) vary with RAS and BRAF mutational status, but their effects on resectability…”
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Targeting Apoptosis Pathways With BCL2 and MDM2 Inhibitors in Adult B‐cell Acute Lymphoblastic Leukemia by Hohtari, Helena, Kankainen, Matti, Adnan‐Awad, Shady, Yadav, Bhagwan, Potdar, Swapnil, Ianevski, Aleksandr, Dufva, Olli, Heckman, Caroline, Sexl, Veronika, Kytölä, Soili, Mustjoki, Satu, Porkka, Kimmo

“…In adult patients, the treatment outcome of acute lymphoblastic leukemia (ALL) remains suboptimal. Here, we used an ex vivo drug testing platform and…”
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