Search Results - "Kyselova, Anastasia"
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Platelet-derived calpain cleaves the endothelial protease-activated receptor 1 to induce vascular inflammation in diabetes
Published in Basic research in cardiology (01-12-2020)“…Diabetes mellitus is a major risk factor for cardiovascular disease. Platelets from diabetic patients are hyperreactive and release microparticles that carry…”
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Calpain 1 cleaves and inactivates prostacyclin synthase in mesenteric arteries from diabetic mice
Published in Basic research in cardiology (01-01-2017)“…Diabetes is associated with a number of co-morbidities including an increased risk of developing cardiovascular diseases. The activation of Ca 2+ -activated…”
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Human platelets are a source of collagen I
Published in Haematologica (Roma) (01-03-2021)Get full text
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Comparative analysis of TGF-β/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines
Published in PloS one (22-08-2013)“…Hepatocellular carcinoma (HCC) is a major public health problem due to increased incidence, late diagnosis and limited treatment options. TGF-β is known to…”
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Association between arginase-containing platelet-derived microparticles and altered plasma arginine metabolism in polycystic ovary syndrome
Published in Metabolism, clinical and experimental (01-01-2019)“…Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disease associated with insulin resistance and increased risk of cardiovascular diseases…”
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Endothelial-dependent S-Sulfhydration of tissue factor pathway inhibitor regulates blood coagulation
Published in Redox biology (01-06-2023)“…Tissue factor pathway inhibitor (TFPI) is an important regulator of coagulation and a link between inflammation and thrombosis. Here we investigated whether…”
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Cyclin Y is expressed in Platelets and Modulates Integrin Outside-in Signaling
Published in International journal of molecular sciences (03-11-2020)“…Diabetes is associated with platelet hyper-reactivity and enhanced risk of thrombosis development. Here we compared protein expression in platelets from…”
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Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function
Published in Circulation (New York, N.Y.) (02-03-2021)“…In vascular endothelial cells, cysteine metabolism by the cystathionine γ lyase (CSE), generates hydrogen sulfide-related sulfane sulfur compounds (H S ), that…”
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Secreted modular calcium-binding protein 1 binds and activates thrombin to account for platelet hyperreactivity in diabetes
Published in Blood (25-03-2021)“…Secreted modular calcium-binding protein 1 (SMOC1) is an osteonectin/SPARC-related matricellular protein, whose expression is regulated by microRNA-223…”
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Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence
Published in Circulation research (27-10-2023)“…Advanced age is unequivocally linked to the development of cardiovascular disease; however, the mechanisms resulting in reduced endothelial cell regeneration…”
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Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function
Published in Circulation (New York, N.Y.) (08-02-2021)Get full text
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