Search Results - "Kysela, B."

Ku70 N-terminal lysines acetylation/deacetylation is required for radiation-induced DNA-double strand breaks repair by Al Emam, A, Arbon, D, Jeeves, M, Kysela, B

“…Ku70 protein in hetero-trimeric complex with Ku80 and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) represents a critical component of the…”
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Nonhomologous End Joining and V(D)J Recombination Require an Additional Factor by Dai, Y., Kysela, B., Hanakahi, L. A., Manolis, K., Riballo, E., Stumm, M., Harville, T. O., West, S. C., Oettinger, M. A., Jeggo, P. A.

“…DNA nonhomologous end-joining (NHEJ) is the major pathway for repairing DNA double-strand breaks in mammalian cells. It also functions to carry out…”
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The Minimum Recording Time for PIV Measurements in a Vessel Agitated by a High-Shear Tooth Impeller by Šulc, R., Ditl, P., Jašíkova, D., Kotek, M., Kopecký, V., Kysela, B.

“…— The flow field in a mechanically agitated vessel has often been investigated by Particle Image Velocimetry (PIV). In published studies, the recording time…”
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Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient by Riballo, E., Critchlow, S.E., Teo, S-H., Doherty, A.J., Priestley, A., Broughton, B., Kysela, B., Beamish, H., Plowman, N., Arlett, C.F., Lehmann, A.R., Jackson, S.P., Jeggo, P.A.

“…The major mechanism for the repair of DNA double-strand breaks (DSBs) in mammalian cells is non-homologous end-joining (NHEJ), a process that involves the…”
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Local Turbulent Energy Dissipation Rate in an Agitated Vessel: Experimental and Turbulence Scaling by Ditl, P., Šulc, R., Pešava, V., Jašíkova, D., Kotek, M., Kopecký, V., Kysela, B.

“…The hydrodynamics and the flow field in an agitated vessel were measured using 2-D time resolved particle image velocimetry (2-D TR PIV). The experiments were…”
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The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity by Beamish, H J, Jessberger, R, Riballo, E, Priestley, A, Blunt, T, Kysela, B, Jeggo, P A

“…DNA-PKcs, the catalytic subunit of DNA-dependent protein kinase (DNA-PK), has a phosphoinositol 3-kinase (PI 3-K) domain close to its C-terminus. Cell lines…”
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Defects in the Kinetics of the Repair of DNA Double-Strand Breaks and Inhibition of DNA Synthesis in the Ataxia Telangiectasia AT5BI-VA Cell Line: Comparison to a Corrected Hybrid, atxbc by Kysela, Boris P., Lohrer, Horst, Arrand, Janet E.

“…The nature of the primary biochemical defect in the human radiosensitive and cancer-prone syndrome, ataxia telangiectasia (AT), has remained obscure despite…”
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Relative contributions of levels of initial DNA damage and repair of double strand breaks to the ionizing radiation-sensitive phenotype of the Chinese hamster cell mutant, XR-V15B. Part I. X-rays by Kysela, B P, Michael, B D, Arrand, J E

“…In order to investigate the relationships between the induction and rejoining of DNA double-strand breaks (dsb) and their biological consequences it is…”
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DNA Ligase IV Mutations Identified in Patients Exhibiting Developmental Delay and Immunodeficiency by O'Driscoll, Mark, Cerosaletti, Karen M., Girard, Pierre-M, Dai, Yan, Stumm, Markus, Kysela, Boris, Hirsch, Betsy, Gennery, Andrew, Palmer, Susan E., Seidel, Jörg, Gatti, Richard A., Varon, Raymonda, Oettinger, Marjorie A., Neitzel, Heidemarie, Jeggo, Penny A., Concannon, Patrick

“…DNA ligase IV functions in DNA nonhomologous end-joining and V(D)J recombination. Four patients with features including immunodeficiency and developmental and…”
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Field-Inversion Gel Electrophoresis Analysis of the Induction and Rejoining of DNA Double-Strand Breaks in Cells Embedded in Agarose by Kysela, Boris P., Michael, Barry D., Arrand, Janet E.

“…Among the techniques available for the measurement of the induction and rejoining of DNA double-strand breaks (DSBs), pulsed-field gel electrophoresis appears…”
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Relative contributions of levels of initial damage and repair of double-strand breaks to the ionizing radiation-sensitive phenotype of the Chinese hamster cell mutant, XR-V15B. Part II. Neutrons by Kysela, B P, Arrand, J E, Michael, B D

“…We have compared DNA double-strand break (dsb) induction and rejoining, using field-inversion gel electrophoresis, with survival in mutant (XR-V15B) and in…”
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Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves’ disease by Brand, Oliver J., Barrett, Jeffrey C., Simmonds, Matthew J., Newby, Paul R., McCabe, Christopher J., Bruce, Christopher K., Kysela, Boris, Carr-Smith, Jackie D., Brix, Thomas, Hunt, Penny J., Wiersinga, Wilmar M., Hegedüs, Laszlo, Connell, John, Wass, John A.H., Franklyn, Jayne A., Weetman, Anthony P., Heward, Joanne M., Gough, Stephen C.L.

“…Graves’ disease (GD) is a common autoimmune disease (AID) that shares many of its susceptibility loci with other AIDs. The thyroid stimulating hormone receptor…”
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Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms by Girard, Pierre-Marie, Kysela, Boris, Härer, Christine J., Doherty, Aidan J., Jeggo, Penny A.

“…LIG4 syndrome patients have hypomorphic mutations in DNA ligase IV. Although four of the five identified patients display immunodeficiency and developmental…”
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Identification of a DNA Nonhomologous End-Joining Complex in Bacteria by Weller, Geoffrey R., Kysela, Boris, Roy, Rajat, Tonkin, Louise M., Scanlan, Elizabeth, Della, Marina, Devine, Susanne Krogh, Day, Jonathan P., Wilkinson, Adam, Fabrizio d'Adda di Fagagna, Devine, Kevin M., Bowater, Richard P., Jeggo, Penny A., Jackson, Stephen P., Doherty, Aidan J.

“…In eukaryotic cells, double-strand breaks (DSBs) in DNA are generally repaired by the pathway of homologous recombination or by DNA nonhomologous end joining…”
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Potential Role for 53BP1 in DNA End-joining Repair through Direct Interaction with DNA by Iwabuchi, Kuniyoshi, Basu, Balaka Piku, Kysela, Boris, Kurihara, Takayuki, Shibata, Masao, Guan, Deyu, Cao, Yongheng, Hamada, Tomio, Imamura, Kouji, Jeggo, Penny A., Date, Takayasu, Doherty, Aidan J.

“…Upon DNA damage, p53-binding protein 1 (53BP1) relocalizes to sites of DNA double-strand breaks and forms discrete nuclear foci, suggesting its role in DNA…”
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Phosphorylation of Linker Histones by DNA-Dependent Protein Kinase Is Required for DNA Ligase IV-Dependent Ligation in the Presence of Histone H1 by Kysela, Boris, Chovanec, Miroslav, Jeggo, Penny A., Alt, Frederick W.

“…DNA nonhomologous end-joining in vivo requires the DNA-dependent protein kinase (DNA-PK) and DNA ligase IV/XRCC4 (LX) complexes. Here, we have examined the…”
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Cellular and Biochemical Impact of a Mutation in DNA Ligase IV Conferring Clinical Radiosensitivity by Riballo, E, Doherty, A J, Dai, Y, Stiff, T, Oettinger, M A, Jeggo, P A, Kysela, B

“…DNA ligase IV functions in DNA non-homologous end-joining, in V(D)J recombination, and during brain development. We previously reported a homozygous mutation…”
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Flow cytometric analysis of primary cervical and vulvar carcinomas and their metastases by Siracký, J, Kysela, B, Siracká, E

“…In a series of 25 patients with cervical carcinoma and 35 patients with vulvar carcinoma, clinically classified (FIGO) as Stage I and Ib, respectively, DNA…”
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Impact of DNA ligase IV on the fidelity of end joining in human cells by Smith, Julianne, Riballo, Enriqueta, Kysela, Boris, Baldeyron, Celine, Manolis, Kostas, Masson, Christel, Lieber, Michael R., Papadopoulo, Dora, Jeggo, Penny

“…A DNA ligase IV (LIG4)‐null human pre‐B cell line and human cell lines with hypomorphic mutations in LIG4 are significantly impaired in the frequency and…”
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Growth, flow cytometric, and karyological characterization of L1210 cell sublines resistant to various Pt derivatives by Hrubisko, M, Kysela, B, Kuliffay, P

“…Growth, flow cytometric, and karyological characteristics were analyzed with respect to differences between sensitive L1210 cells and eight sublines resistant…”
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