Search Results - "Kyra L. Jordan"

Carotid Plaques From Symptomatic Patients Are Characterized by Local Increase in Xanthine Oxidase Expression by Ganji, Morsaleh, Nardi, Valentina, Prasad, Megha, Jordan, Kyra L., Bois, Melanie C., Franchi, Federico, Zhu, Xiang Y., Tang, Hui, Young, Melissa D., Lerman, Lilach O., Lerman, Amir

“…XO (xanthine oxidase) is a key enzyme of uric acid metabolism and is thought to contribute to oxidative pathways that promote atherosclerotic plaque…”
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Impaired immunomodulatory capacity in adipose tissue‐derived mesenchymal stem/stromal cells isolated from obese patients by Zhu, Xiang‐Yang, Klomjit, Nattawat, Conley, Sabena M., Ostlie, Megan M., Jordan, Kyra L., Lerman, Amir, Lerman, Lilach O.

“…Immune‐modulatory properties of adipose tissue‐derived mesenchymal stem/stromal cells (MSCs) might be susceptible to metabolic disturbances. We hypothesized…”
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IL-10 partly mediates the ability of MSC-derived extracellular vesicles to attenuate myocardial damage in experimental metabolic renovascular hypertension by Jiang, Yamei, Hong, Siting, Zhu, Xiangyang, Zhang, Lei, Tang, Hui, Jordan, Kyra L, Saadiq, Ishran M, Huang, Weijun, Lerman, Amir, Eirin, Alfonso, Lerman, Lilach O

“…Extracellular vesicles (EVs) obtain properties of immunomodulation and tissue repair from their parental mesenchymal stem cells (MSCs), and upon delivery may…”
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Valsartan Regulates Myocardial Autophagy and Mitochondrial Turnover in Experimental Hypertension by Zhang, Xin, Li, Zi-Lun, Crane, John A, Jordan, Kyra L, Pawar, Aditya S, Textor, Stephen C, Lerman, Amir, Lerman, Lilach O

“…Renovascular hypertension alters cardiac structure and function. Autophagy is activated during left ventricular hypertrophy and linked to adverse cardiac…”
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The association between circulating microRNA levels and coronary endothelial function by Widmer, R Jay, Chung, Woo-Young, Herrmann, Joerg, Jordan, Kyra L, Lerman, Lilach O, Lerman, Amir

“…Human microRNAs (miRs) have been implicated in human diseases presumably through the downregulation and silencing of targeted genes via post-translational…”
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Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells by Conley, Sabena M, Hickson, LaTonya J, Kellogg, Todd A, McKenzie, Travis, Heimbach, Julie K, Taner, Timucin, Tang, Hui, Jordan, Kyra L, Saadiq, Ishran M, Woollard, John R, Isik, Busra, Afarideh, Mohsen, Tchkonia, Tamar, Kirkland, James L, Lerman, Lilach O

“…Chronic inflammatory conditions like obesity may adversely impact the biological functions underlying the regenerative potential of mesenchymal stromal/stem…”
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Inflammatory and injury signals released from the post-stenotic human kidney by Eirin, Alfonso, Gloviczki, Monika L, Tang, Hui, Gössl, Mario, Jordan, Kyra L, Woollard, John R, Lerman, Amir, Grande, Joseph P, Textor, Stephen C, Lerman, Lilach O

“…The mechanisms mediating kidney injury and repair in humans with atherosclerotic renal artery stenosis (ARAS) remain poorly understood. We hypothesized that…”
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Human liver derived mesenchymal stromal cells ameliorate murine ischemia-induced inflammation through macrophage polarization by Liang, Yun, Ozdogan, Elif, Hansen, Michael J, Tang, Hui, Saadiq, Ishran, Jordan, Kyra L, Krier, James D, Gandhi, Deep B, Grande, Joseph P, Lerman, Lilach O, Taner, Timucin

“…The immunomodulatory properties of mesenchymal stromal cells (MSC) have been well-characterized in and models. We have previously shown that liver MSC (L-MSC)…”
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Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells by Li, Yongxin, Meng, Yu, Zhu, Xiangyang, Saadiq, Ishran M, Jordan, Kyra L, Eirin, Alfonso, Lerman, Lilach O

“…The metabolic syndrome (MetS) is a combination of cardiovascular risk-factors, including obesity, hypertension, hyperglycemia, and insulin resistance. MetS may…”
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Metabolic Syndrome Induces Release of Smaller Extracellular Vesicles from Porcine Mesenchymal Stem Cells by Conley, Sabena M., Shook, John E., Zhu, Xiang-Yang, Eirin, Alfonso, Jordan, Kyra L., Woollard, John R., Isik, Busra, Hickson, LaTonya J., Puranik, Amrutesh S., Lerman, Lilach O.

“…Mesenchymal stromal/stem cells (MSCs) belong to the endogenous cellular reparative system, and can be used exogenously in cell-based therapy. MSCs release…”
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Global epigenetic alterations of mesenchymal stem cells in obesity: the role of vitamin C reprogramming by Afarideh, Mohsen, Thaler, Roman, Khani, Farzaneh, Tang, Hui, Jordan, Kyra L., Conley, Sabena M., Saadiq, Ishran M., Obeidat, Yasin, Pawar, Aditya S., Eirin, Alfonso, Zhu, Xiang-Yang, Lerman, Amir, van Wijnen, Andre J., Lerman, Lilach O.

“…Obesity promotes dysfunction and impairs the reparative capacity of mesenchymal stem/stromal cells (MSCs), and alters their transcription, protein content, and…”
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Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia by Suvakov, Sonja, Cubro, Hajrunisa, White, Wendy M, Butler Tobah, Yvonne S, Weissgerber, Tracey L, Jordan, Kyra L, Zhu, Xiang Y, Woollard, John R, Chebib, Fouad T, Milic, Natasa M, Grande, Joseph P, Xu, Ming, Tchkonia, Tamara, Kirkland, James L, Lerman, Lilach O, Garovic, Vesna D

“…Preeclampsia is a pregnancy-specific hypertensive disorder characterized by impaired angiogenesis. We postulate that senescence of mesenchymal stem cells…”
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Renal Artery Stenosis Alters Gene Expression in Swine Scattered Tubular-Like Cells by Aghajani Nargesi, Arash, Zhu, Xiang-Yang, Liu, Yuanhang, Tang, Hui, Jordan, Kyra L, Lerman, Lilach O, Eirin, Alfonso

“…Scattered tubular-like cells (STCs) proliferate and differentiate to support neighboring injured renal tubular cells during recovery from insults. Renal artery…”
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Endothelial Progenitor Cells Homing and Renal Repair in Experimental Renovascular Disease by Chade, Alejandro R., Zhu, Xiang‐Yang, Krier, James D., Jordan, Kyra L., Textor, Stephen C., Grande, Joseph P., Lerman, Amir, Lerman, Lilach O.

“…Tissue injury triggers reparative processes that often involve endothelial progenitor cells (EPCs) recruitment. We hypothesized that atherosclerotic renal…”
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Low-Energy Shockwave Treatment Promotes Endothelial Progenitor Cell Homing to the Stenotic Pig Kidney by Zhao, Yu, Santelli, Adrian, Zhu, Xiang-Yang, Zhang, Xin, Woollard, John R., Chen, Xiao-Jun, Jordan, Kyra L., Krier, James, Tang, Hui, Saadiq, Ishran, Lerman, Amir, Lerman, Lilach O.

“…Endothelial progenitor cells (EPCs) patrols the circulation and contributes to endothelial cell regeneration. Atherosclerotic renal artery stenosis (ARAS)…”
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Obesity and dyslipidemia are associated with partially reversible modifications to DNA hydroxymethylation of apoptosis- and senescence-related genes in swine adipose-derived mesenchymal stem/stromal cells by Glasstetter, Logan M, Oderinde, Tomiwa S, Mirchandani, Mohit, Rajagopalan, Kamalnath Sankaran, Barsom, Samer H, Thaler, Roman, Siddiqi, Sarosh, Zhu, Xiang-Yang, Tang, Hui, Jordan, Kyra L, Saadiq, Ishran M, van Wijnen, Andre J, Eirin, Alfonso, Lerman, Lilach O

“…Obesity dysregulates key biological processes underlying the functional homeostasis, fate decisions, and reparative potential of mesenchymal stem/stromal cells…”
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Role of Circulating Osteogenic Progenitor Cells in Calcific Aortic Stenosis by Gössl, Mario, MD, Khosla, Sundeep, MD, Zhang, Xin, MD, Higano, Nara, Jordan, Kyra L, Loeffler, Darrell, Enriquez-Sarano, Maurice, MD, Lennon, Ryan J., MSc, Lerman, Lilach O., MD, PhD, Lerman, Amir, MD

“…Objectives The purpose of this study was to determine the role of circulating endothelial progenitor cells with osteoblastic phenotype (EPC-OCN) in human…”
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Metabolic Syndrome Alters the Cargo of Mitochondria-Related microRNAs in Swine Mesenchymal Stem Cell-Derived Extracellular Vesicles, Impairing Their Capacity to Repair the Stenotic Kidney by Eirin, Alfonso, Lerman, Amir, Jordan, Kyra L., Tang, Hui, Zhu, Xiang-Yang, Farahani, Rahele A., Lerman, Lilach O.

“…Background. Coexisting metabolic syndrome (MetS) and renal artery stenosis (RAS) are linked to poor renal outcomes. Mesenchymal stem/stromal cell- (MSC-)…”
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The Metabolic Syndrome Induces Early Changes in the Swine Renal Medullary Mitochondria by Eirin, Alfonso, MD, Woollard, John R, Ferguson, Christopher M, Jordan, Kyra L, Tang, Hui, MD, PhD, Textor, Stephen C., MD, Lerman, Amir, MD, Lerman, Lilach O., MD, PhD

“…Abstract The metabolic syndrome (MetS) is associated with nutrient surplus and kidney hyperfiltration, accelerating chronic renal failure. Mitochondria can be…”
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The Micro-RNA Cargo of Extracellular Vesicles Released by Human Adipose Tissue-Derived Mesenchymal Stem Cells Is Modified by Obesity by Eirin, Alfonso, Meng, Yu, Zhu, Xiang-Yang, Li, Yongxin, Saadiq, Ishran M, Jordan, Kyra L, Tang, Hui, Lerman, Amir, van Wijnen, Andre J, Lerman, Lilach O

“…Obesity is a chronic disease that interferes with normal repair processes, including adipose mesenchymal stem/stromal cells (ASCs) function. ASCs produce…”
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