Search Results - "Kyoi, Takashi"

Inhibitory Effects of Saururus chinensis Extract on Receptor for Advanced Glycation End-Products-Dependent Inflammation and Diabetes-Induced Dysregulation of Vasodilation by Hayashi, Kenjiro, Sato, Koichi, Ochi, Seishi, Kawano, Shuhei, Munesue, Seiichi, Harashima, Ai, Oshima, Yu, Kimura, Kumi, Kyoi, Takashi, Yamamoto, Yasuhiko

“…Advanced glycation end-products (AGEs) and the receptor for AGEs (RAGE) are implicated in inflammatory reactions and vascular complications in diabetes…”
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Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats by Zhang, Xin, Tajima, Koyuki, Kageyama, Kiyoto, Kyoi, Takashi

“…To investigate the mucosal protective effect and the mechanisms of action of the anti-ulcer drug irsogladine maleate in gastric injury induced by indomethacin…”
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Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia by Ito, Sunao, Tajima, Koyuki, Nogawa, Masaki, Inoue, Naoki, Kyoi, Takashi, Takahashi, Yosuke, Sasagawa, Takahiro, Nakamura, Akio, Kotera, Takashi, Ueda, Makoto, Yamashita, Yasuhiro, Banno, Kouji

“…The effect of the cyclooxygenase-2 (COX-2) inhibitor etodolac on the mechanical allodynia induced by paclitaxel was investigated in mice and compared with the…”
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The Enantiomers of Etodolac, a Racemic Anti-inflammatory Agent, Play Different Roles in Efficacy and Gastrointestinal Safety by Inoue, Naoki, Nogawa, Masaki, Ito, Sunao, Tajima, Koyuki, Kume, Sato, Kyoi, Takashi

“…The anti-inflammatory agent etodolac is used worldwide and it has a good gastrointestinal safety profile. Etodolac consists of two enantiomers, S- and…”
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Etodolac Attenuates Mechanical Allodynia in a Mouse Model of Neuropathic Pain by Inoue, Naoki, Ito, Sunao, Tajima, Koyuki, Nogawa, Masaki, Takahashi, Yosuke, Sasagawa, Takahiro, Nakamura, Akio, Kyoi, Takashi

“…Cyclooxygenase (COX) contributes to neuropathic pain after peripheral nerve injury, yet COX inhibitors are generally ineffective against mechanical allodynia…”
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Etodolac blocks the allyl isothiocyanate-induced response in mouse sensory neurons by selective TRPA1 activation by Inoue, Naoki, Ito, Sunao, Nogawa, Masaki, Tajima, Koyuki, Kyoi, Takashi

“…The excitability of nociceptors is modulated by the transient receptor potential cation channel, ankyrin subfamily, member 1 (TRPA1). We have previously…”
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Pharmacological Profile of the Novel Anti-inflammatory Corticosteroid NS-126, a Therapeutic Agent for Allergic Rhinitis by Inoue, Naoki, Hashino, Asami, Kageyama, Kiyoto, Zhang, Xin, Sasagawa, Takahiro, Kawakita, Naoko, Takahashi, Yosuke, Yoshida, Katsumi, Hashimoto, Mikiko, Mori, Kazuya, Kyoi, Takashi

“…NS-126 (9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-cyclohexanecarboxylate 17-cyclopropanecarboxylate) is a novel, highly lipophilic…”
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Phosphodiesterase Type IV Inhibitors Prevent Ischemia-Reperfusion-Induced Gastric Injury in Rats by Kyoi, Takashi, Kitazawa, Satoru, Tajima, Koyuki, Zhang, Xin, Ukai, Yojiro

“…The effects of selective inhibitors of phosphodiesterase type IV (PDE4) on ischemia-reperfusion-induced gastric injuries were investigated in rats. Gastric…”
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Irsogladine Prevents Monochloramine-Induced Gastric Mucosal Lesions by Improving the Decrease in Mucosal Blood Flow Due to the Disturbance of Nitric Oxide Synthesis in Rats by Kyoi, Takashi, Oka, Michiko, Noda, Kumiko, Ukai, Yojiro

“…The inhibitory effect of an anti-ulcer drug irsogladine [2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate] on monochloramine (NH2Cl)-induced gastric…”
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Phosphodiesterase inhibition by a gastroprotective agent irsogladine: Preferential blockade of cAMP hydrolysis by Kyoi, Takashi, Oka, Michiko, Noda, Kumiko, Ukai, Yojiro

“…The effect of irsogladine [2,4-diamino-6-(2,5-dichlorophenyl)- s-triazine maleate], an antiulcer drug, on contents of cyclic nucleotides including cAMP and…”
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Effect of the 5-HT3 receptor antagonist granisetron on estramustine phosphate sodium (Estracyt)-induced emesis in ferrets by Higashioka, Masaya, Yamaguchi, Emi, Takatori, Shingo, Tanaka, Mitsushi, Kyoi, Takashi

“…Estracyt(R) is an antimitotic drug used for the treatment of prostate cancer, and its most common adverse effects are nausea and vomiting. In this study, we…”
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Irsogladine Prevents Monochloramine-Induced Gastric Mucosal Lesions by Improving the Decrease in Mucosal Blood Flow Due to the Disturbance of Nitric Oxide Synthesis in Rats by Kyoi, Takashi, Oka, Michiko, Noda, Kumiko, Ukai, Yojiro

“…The inhibitory effect of an anti-ulcer drug irsogladine [2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate] on monochloramine (NH2Cl)-induced gastric…”
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Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils by Kyoi, Takashi, Noda, Kumiko, Oka, Michiko, Ukai, Yojiro

“…Neutrophil superoxide production is implicated in the pathogenesis of gastric mucosal damage induced by various ulcerative agents and Helicobacter pylori…”
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Zrsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats by Xin Zhang Koyuki Tajima Kiyoto Kageyama Takashi Kyoi

“…AIM： To investigate the mucosal protective effect and the mechanisms of action of the anti-ulcer drug irsogladine maleate in gastric injury induced by…”
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Suppression of superoxide production in human neutrophils through inhibition of PDE4：An implication for a role of cAMP in anti-ulcer action of irsogladine by Michiko Oka, Kumiko Noda, Takashi Kyoi

“…We investigated the effects of irsogladine on cAMP level in isolated human neutrophils. Among selective inhibitors for PDE isozymes (PDE1-PDE4), only rolipram…”
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Phosphodiesterase Type IV Inhibitors Prevent Ischemia-Reperfusion-Induced Gastric Injury in Rats by Takashi Kyoi, Satoru Kitazawa, Koyuki Tajima, Xin Zhang, Yojiro Ukai

“…The effects of selective inhibitors of phosphodiesterase type IV (PDE4) on ischemia-reperfusion-induced gastric injuries were investigated in rats. Gastric…”
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Synergistic effect of irsogladine maleate and histamine H2-receptor antagonists on experimental gastric ulcers in rats by Ueda, F, Kyoi, T, Kimura, K

“…Effects of irsogladine maleate (IM), in combination with histamine H2-receptor antagonists or a muscarinic receptor antagonist, on the formation of stress…”
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Intercellular communication of cultured rabbit gastric epithelial cells by Kyoi, Takashi, Mimura, Kiyotaka, Ueda, Fusao, Kimura, Kiyoshi

“…We studied the effects of gastric secretagogues (histamine, pentagastrin and carbachol), adrenergic agents (epinephrine, norepinephrine, isoproterenol, and…”
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Intercellular Communication in Cultured Rabbit Gastric Epithelial Cells by Ueda, Fusao, Kyoi, Takashi, Mimura, Kiyotaka, Kimura, Kiyoshi, Yamamoto, Masao

“…The effects of drugs related to cyclic AMP and a tumor promoter, phorbol ester, on intercellular communications via gap junctions were investigated by the…”
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Intercellular Communication in Cultured Rabbit Gastric Epithelial Cells by Ueda, Fusao, Kyoi, Takashi, Mimura, Kiyotaka, Kimura, Kiyoshi, Yamamoto, Masao

“…The effects of drugs related to cyclic AMP and a tumor promoter, phorbol ester, on intercellular communications via gap junctions were investigated by the…”
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