Search Results - "Kyncl, John J"

Conformationally defined adrenergic agents. 4. 1-(Aminomethyl)phthalans: synthesis and pharmacological consequences of the phthalan ring oxygen atom by DeBernardis, John F, Arendsen, David L, Kyncl, John J, Kerkman, Daniel J

“…The synthesis of a series of 1-(aminomethyl)phthalans 1b is reported. The radioligand binding to alpha 1- and alpha 2-receptors and the in vitro pharmacology…”
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Conformationally defined adrenergic agents. 3. Modifications to the carbocyclic ring of 5,6-dihydroxy-1-(2-imidazolinyl)tetralin: improved separation of .alpha.1 and .alpha.2 adrenergic activities by DeBernardis, John F, Winn, Martin, Arendsen, David L, Kerkman, Daniel J, Kyncl, John J

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A new nasal decongestant, A-57219: a comparison with oxymetazoline by DeBernardis, J F, Winn, M, Kerkman, D J, Kyncl, J J, Buckner, S, Horrom, B

“…2-(4-Amino-3,5-dichlorobenzyl)imidazoline hydrochloride (A-57219), has alpha 1-agonist/alpha 2-antagonist activity and was more effective and long-acting than…”
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Conformationally defined adrenergic agents. 5. Resolution, absolute configuration, and pharmacological characterization of the enantiomers of 2-(5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthyl)imidazoline: a potent agonist at .alpha.-adrenoceptors by DeBernardis, John F, Kerkman, Daniel J, Arendsen, David L, Buckner, Steve A, Kyncl, John J, Hancock, Arthur A

“…(+/-)-2-(5,6-Dimethoxy-1,2,3,4-tetrahydro-1-naphthyl)imidazoline has been resolved into its (+) and (-) enantiomers, and the absolute configuration was…”
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Conformationally defined adrenergic agents. 2. Catechol imidazoline derivatives: biological effects at .alpha.1 and .alpha.2 adrenergic receptors by DeBernardis, John F, Kyncl, John J, Basha, Fatima Z, Arendsen, David L, Martin, Yvonne C, Winn, Martin, Kerkman, Daniel J

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Novel adrenergic compounds. I. Receptor interactions of ABBOTT-54741 [(5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthtyl)imidazoline], an alpha-adrenergic agonist by Kyncl, J J, DeBernardis, J F, Bush, E N, Buckner, S A, Brondyk, H

“…ABBOTT-54741 was identified as a full alpha-adrenergic agonist; its interaction with the alpha-adrenergic receptor was compared to that of norepinephrine…”
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Adrenergic and dopaminergic properties of dopamine sulfoconjugates by Kyncl, J J, Buckner, S A, Brondyk, H, Kerkman, D J, DeBernardis, J F, Bush, E N, Kuchel, O

“…The 3- and 4-sulfate esters of dopamine (DA-3-SO4 and DA-4-SO4, respectively), the two main metabolites of DA, were evaluated for potential intrinsic or…”
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Conformationally defined adrenergic agents. 1. Design and synthesis of novel .alpha.2-selective adrenergic agents: electrostatic repulsion based conformational prototypes by DeBernardis, John F, Kerkman, Daniel J, Winn, Martin, Bush, Eugene N, Arendsen, David L, McClellan, William J, Kyncl, John J, Basha, Fatima Z

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Pharmacology of terazosin by Kyncl, J J

“…Terazosin is a quinazoline antihypertensive agent that is chemically similar to prazosin. The saturated furan ring of terazosin distinguishes these two…”
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Data normalization before statistical analysis: keeping the horse before the cart by Hancock, A A, Bush, E N, Stanisic, D, Kyncl, J J, Lin, C T

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Alpha 1-adrenoceptor properties of terazosin HCl and its enantiomers in the human prostate and canine brain by Meretyk, S, Tang, R, Shapiro, E, Kyncl, J J, Lepor, H

“…The objective of the present study was to characterize the alpha 1-adrenoceptor binding properties of terazosin and its enantiomers in human prostate and…”
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Differentiation of alpha-adrenergic receptors using pharmacological evaluation and molecular modeling of selective adrenergic agents by Hancock, A A, Kyncl, J J, Martin, Y C, DeBernardis, J F

“…Subtypes of alpha adrenergic receptors were studied using selective adrenergic agonists. A-53693, A-54741, and related compounds were evaluated for their…”
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Similarity of central and peripheral alpha-1 adrenoceptors in rat and rabbit by Bush, E N, Walker, D E, Stanisic, D, DeBernardis, J F, Kyncl, J J

“…In order to examine species and tissue differences in alpha 1 adrenoceptors, binding experiments were performed using 3H-prazosin and membrane homogenates of…”
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