Search Results - "Kyle O'Hagan"

Pak2 is essential for the function of Foxp3+ regulatory T cells through maintaining a suppressive Treg phenotype by O’Hagan, Kyle L., Miller, Stephen D., Phee, Hyewon

“…Foxp3, a key transcription factor that drives lineage differentiation of regulatory T cells (Tregs), was thought to imprint a unique and irreversible genetic…”
Get full text

Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells by Hunter, Morgan C, O'Hagan, Kyle L, Kenyon, Amy, Dhanani, Karim C H, Prinsloo, Earl, Edkins, Adrienne L

“…Heat shock protein 90 (Hsp90) has been identified in the extracellular space and has been shown to chaperone a finite number of extracellular proteins involved…”
Get full text

Pak2 Controls Acquisition of NKT Cell Fate by Regulating Expression of the Transcription Factors PLZF and Egr2 by O'Hagan, Kyle L, Zhao, Jie, Pryshchep, Olga, Wang, Chyung-Ru, Phee, Hyewon

“…NKT cells constitute a small population of T cells developed in the thymus that produce large amounts of cytokines and chemokines in response to lipid Ags…”
Get full text

Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance by O'Hagan, Kyle Leonard, Choi, Jinyong, Pryshchep, Olga, Chernoff, Jonathan, Phee, Hyewon

“…Although significant effort has been devoted to understanding the thymic development of Foxp3(+) regulatory T cells (Tregs), the precise signaling pathways…”
Get full text

Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation by Phee, Hyewon, Au-Yeung, Byron B, Pryshchep, Olga, O'Hagan, Kyle Leonard, Fairbairn, Stephanie Grace, Radu, Maria, Kosoff, Rachelle, Mollenauer, Marianne, Cheng, Debra, Chernoff, Jonathan, Weiss, Arthur

“…The molecular mechanisms that govern thymocyte development and maturation are incompletely understood. The P21-activated kinase 2 (Pak2) is an effector for the…”
Get full text

Impact of chemokine C–C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males by Gray, Clive M., O’Hagan, Kyle L., Lorenzo-Redondo, Ramon, Olivier, Abraham J., Amu, Sylvie, Chigorimbo-Murefu, Nyaradzo, Harryparsad, Rushil, Sebaa, Shorok, Maziya, Lungile, Dietrich, Janan, Otwombe, Kennedy, Martinson, Neil, Ferrian, Selena, Mkhize, Nonhlanhla N., Lewis, David A., Lang, Dirk, Carias, Ann M., Jaspan, Heather B., Wilson, Douglas P. K., McGilvray, Marcus, Cianci, Gianguido C., Anderson, Meegan R., Dinh, Minh H., Williamson, Anna-Lise, Passmore, Jo-Ann S., Chiodi, Francesca, Hope, Thomas J.

“…We compared outer and inner foreskin tissue from adolescent males undergoing medical male circumcision to better understand signals that increase HIV target…”
Get full text

Combined HIV Adolescent Prevention Study (CHAPS): comparison of HIV pre-exposure prophylaxis regimens for adolescents in sub-Saharan Africa—study protocol for a mixed-methods study including a randomised controlled trial by Nash, S., Dietrich, J., Ssemata, A. S., Herrera, C., O’Hagan, K., Else, L., Chiodi, F., Kelly, C., Shattock, R., Chirenje, M., Lebina, L., Khoo, S., Bekker, L-G, Weiss, H. A., Gray, C., Stranix-Chibanda, L., Kaleebu, P., Seeley, J., Martinson, N., Fox, J.

“…Background HIV remains a major public health issue, especially in Eastern and Southern Africa. Pre-exposure prophylaxis is highly effective when adhered to,…”
Get full text

Hsp90 Binds Directly to Fibronectin by Hunter, Morgan C, O'Hagan, Kyle L, Kenyon, Amy, Dhanani, Karim C. H, Prinsloo, Earl, Edkins, Adrienne L

“…Heat shock protein 90 (Hsp90) has been identified in the extracellular space and has been shown to chaperone a finite number of extracellular proteins involved…”
Get full text

Dose finding study for on-demand HIV pre-exposure prophylaxis for insertive sex in sub-Saharan Africa: results from the CHAPS open label randomised controlled trial by Herrera, Carolina, Serwanga, Jennifer, Else, Laura, Limakatso, Lebina, Opoka, Daniel, Ssemata, Andrew S., Pillay, Azure-Dee, Namubiru, Patricia, Seiphetlo, Thabiso B., Odoch, Geoffrey, Mugaba, Susan, Seatlholo, Portia, Alieu, Amara, Penchala, Sujan Dilly, Muhumuza, Richard, Alinde, Berenice, Petkov, Stefan, O'Hagan, Kyle, Callebaut, Christian, Seeley, Janet, Weiss, Helen, Khoo, Saye, Chiodi, Francesca, Gray, Clive M., Kaleebu, Pontiano, Webb, Emily L., Martinson, Neil, Fox, Julie, Ahmed, Nadia, Alinde, Berenice, Alieu, Amara, Atujuna, Millicent, Awino, Esther, Bekker, Linda-Gail, Callebaut, Christian, Chiodi, Francesca, Chirenje, Mike, Dietrich, Janan, Dorfman, Jeffrey, Else, Laura, Fox, Julie, Gray, Clive, Hansen, Christian Holm, Herrera, Carolina, Hornschuh, Stefanie, Kakande, Ayoub, Kaleebu, Pontiano, Kelly, Charles, Khoo, Saye, Khunwane, Mamkiri, Lebina, Limaktso, Makhura, Joseph, Mangxilana, Nomvuyo, Martinson, Neil, Mugaba, Susan, Muhumuza, Richard, Kibengo, Freddie Mukasa, Mutonyi, Gertrude, Mungate, Lucia, Nabukeera, Winnie, Nagawa, Rehema, Nalubega, Phiona, Namubiru, Patricia, Nash, Stephen, Ndekezi, Denis, Nematadzira, Teacler, Nobula, Lumka, O'Hagan, Kyle, Odoch, Geoffrey, Opoka, Daniel, Penchala, Sujan Dilly, Petkov, Stefan, Pillay, Azure-Dee, Rooney, Jim, Rousseau, Elzette, Ruzagira, Eugene, Sango, Alison, Seatlholo, Ntombexolo, Seeley, Janet, Seiphetlo, Thabiso, Serwanga, Jennifer, Shattock, Robin, Ssemata, Andrew S., Stranix-Chibanda, Lynda, Tshabalala, Gugulethu, Webb, Emily, Weiss, Helen

“…The efficacy of on-demand HIV pre-exposure prophylaxis (PrEP) for men in sub-Saharan Africa has not been evaluated, and the on-demand PrEP dosing requirement…”
Get full text

Dose finding study for on-demand HIV pre-exposure prophylaxis for insertive sex in sub-Saharan Africa: results from the CHAPS open label randomised controlled trialResearch in context by Carolina Herrera, Jennifer Serwanga, Laura Else, Lebina Limakatso, Daniel Opoka, Andrew S. Ssemata, Azure-Dee Pillay, Patricia Namubiru, Thabiso B. Seiphetlo, Geoffrey Odoch, Susan Mugaba, Portia Seatlholo, Amara Alieu, Sujan Dilly Penchala, Richard Muhumuza, Berenice Alinde, Stefan Petkov, Kyle O'Hagan, Christian Callebaut, Janet Seeley, Helen Weiss, Saye Khoo, Francesca Chiodi, Clive M. Gray, Pontiano Kaleebu, Emily L. Webb, Neil Martinson, Julie Fox, Nadia Ahmed, Berenice Alinde, Amara Alieu, Millicent Atujuna, Esther Awino, Linda-Gail Bekker, Christian Callebaut, Francesca Chiodi, Mike Chirenje, Janan Dietrich, Jeffrey Dorfman, Laura Else, Julie Fox, Clive Gray, Christian Holm Hansen, Carolina Herrera, Stefanie Hornschuh, Ayoub Kakande, Pontiano Kaleebu, Charles Kelly, Saye Khoo, Mamkiri Khunwane, Limaktso Lebina, Joseph Makhura, Nomvuyo Mangxilana, Neil Martinson, Susan Mugaba, Richard Muhumuza, Freddie Mukasa Kibengo, Gertrude Mutonyi, Lucia Mungate, Winnie Nabukeera, Rehema Nagawa, Phiona Nalubega, Patricia Namubiru, Stephen Nash, Denis Ndekezi, Teacler Nematadzira, Lumka Nobula, Kyle O'Hagan, Geoffrey Odoch, Daniel Opoka, Sujan Dilly Penchala, Stefan Petkov, Azure-Dee Pillay, Jim Rooney, Elzette Rousseau, Eugene Ruzagira, Alison Sango, Ntombexolo Seatlholo, Janet Seeley, Thabiso Seiphetlo, Jennifer Serwanga, Robin Shattock, Andrew S. Ssemata, Lynda Stranix-Chibanda, Gugulethu Tshabalala, Emily Webb, Helen Weiss

“…Background: The efficacy of on-demand HIV pre-exposure prophylaxis (PrEP) for men in sub-Saharan Africa has not been evaluated, and the on-demand PrEP dosing…”
Get full text

Pak2: An Essential Regulator of T Regulatory and Natural Killer T Cell Development and Function by O'Hagan, Kyle Leonard

“…T cell development in the thymus selects for several distinct lineages that each possess unique and important functions in immune regulation. While the…”
Get full text