Search Results - "Kyeremateng, Samuel O"

Long-Term Physical Stability of PVP- and PVPVA-Amorphous Solid Dispersions by Lehmkemper, Kristin, Kyeremateng, Samuel O, Heinzerling, Oliver, Degenhardt, Matthias, Sadowski, Gabriele

“…The preparation of amorphous solid dispersion (ASD) formulations is a promising strategy to improve the bioavailability of an active pharmaceutical ingredient…”
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Impact of Polymer Type and Relative Humidity on the Long-Term Physical Stability of Amorphous Solid Dispersions by Lehmkemper, Kristin, Kyeremateng, Samuel O, Heinzerling, Oliver, Degenhardt, Matthias, Sadowski, Gabriele

“…The purpose of this work is to compare the long-term physical stability of amorphous solid dispersion (ASD) formulations based on three different commercially…”
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Kinetics of Water-Induced Amorphous Phase Separation in Amorphous Solid Dispersions via Raman Mapping by Krummnow, Adrian, Danzer, Andreas, Voges, Kristin, Kyeremateng, Samuel O, Degenhardt, Matthias, Sadowski, Gabriele

“…The poor bioavailability of an active pharmaceutical ingredient (API) can be enhanced by dissolving it in a polymeric matrix. This formulation strategy is…”
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System-agnostic prediction of pharmaceutical excipient miscibility via computing-as-a-service and experimental validation by Antipas, Georgios S. E., Reul, Regina, Voges, Kristin, Kyeremateng, Samuel O., Ntallis, Nikolaos A., Karalis, Konstantinos T., Miroslaw, Lukasz

“…We applied computing-as-a-service to the unattended system-agnostic miscibility prediction of the pharmaceutical surfactants, Vitamin E TPGS and Tween 80, with…”
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Synthesis and Characterization of Biodegradable Poly(butyl cyanoacrylate) for Drug Delivery Applications by Keller, Benjamin-Luca, Lohmann, Claudia A, Kyeremateng, Samuel O, Fricker, Gert

“…Poly(butyl cyanoacrylate) (PBCA) is a biodegradable and biocompatible homopolymer which is used as a carrier matrix for drug delivery systems in the…”
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Explaining the Release Mechanism of Ritonavir/PVPVA Amorphous Solid Dispersions by Krummnow, Adrian, Danzer, Andreas, Voges, Kristin, Dohrn, Stefanie, Kyeremateng, Samuel O, Degenhardt, Matthias, Sadowski, Gabriele

“…In amorphous solid dispersions (ASDs), an active pharmaceutical ingredient (API) is dissolved on a molecular level in a polymeric matrix. The API is expected…”
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Thermodynamic Modeling of the Amorphous Solid Dispersion-Water Interfacial Layer and Its Impact on the Release Mechanism by Dohrn, Stefanie, Kyeremateng, Samuel O, Bochmann, Esther, Sobich, Ekaterina, Wahl, Andrea, Liepold, Bernd, Sadowski, Gabriele, Degenhardt, Matthias

“…During the dissolution of amorphous solid dispersion (ASD) formulations, the gel layer that forms at the ASD/water interface strongly dictates the release of…”
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Predicting the Release Mechanism of Amorphous Solid Dispersions: A Combination of Thermodynamic Modeling and In Silico Molecular Simulation by Walter, Stefanie, Mileo, Paulo G M, Afzal, Mohammad Atif Faiz, Kyeremateng, Samuel O, Degenhardt, Matthias, Browning, Andrea R, Shelley, John C

“…During the dissolution of amorphous solid dispersion (ASD) formulations, the drug load (DL) often impacts the release mechanism and the occurrence of loss of…”
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Predicting process design spaces for spray drying amorphous solid dispersions by Dohrn, Stefanie, Rawal, Pranay, Luebbert, Christian, Lehmkemper, Kristin, Kyeremateng, Samuel O., Degenhardt, Matthias, Sadowski, Gabriele

“…Amorphous solid dispersions (ASDs) are commonly manufactured using spray-drying processes. The product quality can be decisively influenced by the choice of…”
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Synthesis and Self-Organization of Poly(propylene oxide)-Based Amphiphilic and Triphilic Block Copolymers by Kyeremateng, Samuel O, Busse, Karsten, Kohlbrecher, Joachim, Kressler, Jörg

“…A series of amphiphilic diblock copolymers and triphilic triblock copolymer analogues of the architectures BA, CAB, and CBA have been synthesized and…”
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A Hot-Melt Extrusion Risk Assessment Classification System for Amorphous Solid Dispersion Formulation Development by Kyeremateng, Samuel O, Voges, Kristin, Dohrn, Stefanie, Sobich, Ekaterina, Lander, Ute, Weber, Stefan, Gessner, David, Evans, Rachel C, Degenhardt, Matthias

“…Several literature publications have described the potential application of active pharmaceutical ingredient (API)-polymer phase diagrams to identify…”
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Solvent influence on the phase behavior and glass transition of Amorphous Solid Dispersions by Dohrn, Stefanie, Luebbert, Christian, Lehmkemper, Kristin, Kyeremateng, Samuel O., Degenhardt, Matthias, Sadowski, Gabriele

“…[Display omitted] Understanding the long-term stability of amorphous solid dispersions (ASDs) is important for their successful approval for market. ASD…”
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Phase behavior of pharmaceutically relevant polymer/solvent mixtures by Dohrn, Stefanie, Luebbert, Christian, Lehmkemper, Kristin, Kyeremateng, Samuel O., Degenhardt, Matthias, Sadowski, Gabriele

“…[Display omitted] In the pharmaceutical industry, polymers are used as excipients for formulating poorly water-soluble active pharmaceutical ingredients (APIs)…”
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A fast and reliable empirical approach for estimating solubility of crystalline drugs in polymers for hot melt extrusion formulations by Kyeremateng, Samuel O, Pudlas, Marieke, Woehrle, Gerd H

“…A novel empirical analytical approach for estimating solubility of crystalline drugs in polymers has been developed. The approach utilizes a combination of…”
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Influence of Low-Molecular-Weight Excipients on the Phase Behavior of PVPVA64 Amorphous Solid Dispersions by Lehmkemper, Kristin, Kyeremateng, Samuel O., Degenhardt, Matthias, Sadowski, Gabriele

“…Purpose The oral bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs) can be improved by the preparation of amorphous solid…”
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Impact of surfactant raw material variability on extrudate clarity appearance (transparency) in HME continuous manufacturing by Lohmann, Claudia A, Bochmann, Esther, Kyeremateng, Samuel O

“…The appearance of an extrudate formulation was monitored during hot-melt extrusion (HME) continuous manufacturing over 3 days. The formulation matrix consisted…”
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Physical stability of API/polymer-blend amorphous solid dispersions by Lehmkemper, Kristin, Kyeremateng, Samuel O., Bartels, Mareike, Degenhardt, Matthias, Sadowski, Gabriele

“…[Display omitted] The preparation of amorphous solid dispersions (ASDs) is a well-established strategy for formulating active pharmaceutical ingredients by…”
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Thermodynamic Modeling of Solvent-Impact on Phase Separation in Amorphous Solid Dispersions during Drying by Dohrn, Stefanie, Reimer, Philipp, Luebbert, Christian, Lehmkemper, Kristin, Kyeremateng, Samuel O, Degenhardt, Matthias, Sadowski, Gabriele

“…Understanding and prevention of unwanted changes of a pharmaceutical formulation during the production process is part of the critical requirements for the…”
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Holistic QbD approach for hot-melt extrusion process design space evaluation: Linking materials science, experimentation and process modeling by Evans, Rachel C., Bochmann, Esther S., Kyeremateng, Samuel O., Gryczke, Andreas, Wagner, Karl G.

“…[Display omitted] The aim of this work was to investigate the relationship between formulation material properties, process parameters and process performance…”
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Extraordinary Long-Term-Stability in Kinetically Stabilized Amorphous Solid Dispersions of Fenofibrate by Theil, Frank, Milsmann, Johanna, Kyeremateng, Samuel O, Anantharaman, Sankaran, Rosenberg, Jörg, van Lishaut, Holger

“…Inhibition of recrystallization of the drug substance in kinetically stabilized amorphous solid dispersions (ASDs) within and beyond shelf life is still a…”
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