Effect of 4-Hexylresorcinol on the Efficiency of Antibiotic Treatment of Experimental Sepsis Caused by Antibiotic-Resistant Klebsiella pneumoniae Strain in Mice

High efficiency of a combined preparation including synergistic polymyxin B and 4-hexylresorcinol was shown for treatment of experimental sepsis caused by an antibiotic-resistant highly virulent hypermucoid Klebsiella pneumoniae strain KPM9Pm r in mice. Complex therapy with polymyxin B (1 mg/kg) and...

Full description

Saved in:

Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 171; no. 4; pp. 458 - 460
Main Authors:	Shemyakin, I. G., Manzenyuk, O. Yu, El’-Registan, G. I., Firstova, V. V., Kombarova, T. I., Gneusheva, T. Yu, Kyazimov, E. I., Nikolaev, Yu. A.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-08-2021 Springer Springer Nature B.V
Subjects:	Analysis Animals Animals, Outbred Strains Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotic resistance Antibiotics Bacterial pneumonia Biomedical and Life Sciences Biomedicine Cell Biology Comparative analysis Disease Models, Animal Drug resistance Drug resistance in microorganisms Drug Resistance, Multiple, Bacterial - drug effects Drug Synergism Drug therapy Efficiency Female Hexylresorcinol - pharmacology Internal Medicine Klebsiella Infections - complications Klebsiella Infections - drug therapy Klebsiella Infections - pathology Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - pathogenicity Laboratory Medicine Mice Microbial Sensitivity Tests Pathology Pneumonia Polymyxin B Polymyxin B - pharmacology Polymyxin B - therapeutic use Polymyxins - analogs & derivatives Polymyxins - pharmacology Polymyxins - therapeutic use Sepsis Sepsis - drug therapy Sepsis - microbiology Virulence (Microbiology) polymyxin Klebsiella pneumoniae Pm sanified mice antibiotic resistance 4-hexylresorcinol Klebsiella pneumoniae Pmr
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	High efficiency of a combined preparation including synergistic polymyxin B and 4-hexylresorcinol was shown for treatment of experimental sepsis caused by an antibiotic-resistant highly virulent hypermucoid Klebsiella pneumoniae strain KPM9Pm r in mice. Complex therapy with polymyxin B (1 mg/kg) and 4-hexylresorcinol (30 mg/kg) led to cure in 80%; in 20% of these mice, no bacterial cells were found. After treatment with polymyxin B alone, only 50% animals survived and all of them contained bacterial cells. Comparative analysis of the results of monotherapy and combined treatment indicates that 4-hexylresorcinol not only increases the efficiency of antibiotic, but also minimizes persistence of the infection agent and therefore, the risk of development of antibiotic resistance.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-021-05249-6