Search Results - "Kyan, Ryuji"
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Late-Stage Derivatization of Oleanolic Acid-Based Anti-HIV-1 Compounds
Published in Chemical & pharmaceutical bulletin (25-03-2024)“…A 12-keto-type oleanolic acid derivative (4) has been identified as a potent anti-human immunodeficiency virus type-1 (HIV-1) compound that demonstrates…”
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Tuning the Catalyst Reactivity of Imidazolylidene Catalysts through Substituent Effects on the N‑Aryl Groups
Published in Organic letters (19-05-2017)“…A series of imidazolium salts with various N-aryl groups were synthesized, and their catalytic activities were evaluated to investigate the contribution of the…”
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Chemoselective Umpolung of Enals for Asymmetric Homoenolate Cross-Annulation of Enals and Aldehydes Catalyzed by N‑Heterocyclic Carbene
Published in Organic letters (15-11-2019)“…An asymmetric homoenolate cross-annulation of enals and aldehydes with high enantioselectivity is realized by NHC-catalyzed chemoselective umpolung of enals…”
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Theoretical study to gain fundamental insight into reaction mechanism of N-S acyl transfer of N-sulfanylethylanilide-based protein labeling reagent on protein surface
Published in Journal of peptide science (01-12-2023)“…Elucidation of protein function is one of the central issues in the field of life sciences. To study the function of proteins not in isolation, but in a cell…”
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5
Pendant Alkoxy Groups on N‐Aryl Substitutions Drive the Efficiency of Imidazolylidene Catalysts for Homoenolate Annulation from Enal and Aldehyde
Published in Angewandte Chemie International Edition (19-10-2020)“…Hydrogen‐transfer in the tetrahedral intermediate generated from an imidazolylidene catalyst and α,β‐unsaturated aldehyde forms a conjugated Breslow…”
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6
Residue‐Selective C−H Sulfenylation Enabled by Acid‐Activated S‐Acetamidomethyl Cysteine Sulfoxide with Application to One‐Pot Stapling and Lipidation Sequence
Published in Chemistry : a European journal (08-05-2023)“…A tyrosine (Tyr)‐ or tryptophan (Trp)‐selective metal‐free C−H sulfenylation reaction using an acid‐activated S‐acetamidomethyl cysteine (Cys) sulfoxide,…”
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7
β,γ-trans-selective γ-butyrolactone formation via homoenolate cross-annulation of enals and aldehydes catalyzed by sterically hindered N-heterocyclic carbene
Published in Tetrahedron (02-07-2021)“…Highly sterically hindered N-heterocyclic carbenes (NHCs), can be readily prepared from the corresponding anilines, and serve as organocatalysts in…”
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Cover Feature: Residue‐Selective C−H Sulfenylation Enabled by Acid‐Activated S‐Acetamidomethyl Cysteine Sulfoxide with Application to One‐Pot Stapling and Lipidation Sequence (Chem. Eur. J. 26/2023)
Published in Chemistry : a European journal (08-05-2023)“…The aromatic (C−H) sulfenylation reaction with S‐acetamidomethyl cysteine sulfoxide (Cys(Acm)(O)) can be Trp‐ or Tyr‐selective under acidic conditions. The red…”
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Improvement of chemical stability of conjugated dienes by chlorine substitution
Published in Tetrahedron (08-11-2018)“…Conjugated systems have versatile utilities in various fields including organic synthesis, pharmaceutical development, and material science. Such systems take…”
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Pendant Alkoxy Groups on N‐Aryl Substitutions Drive the Efficiency of Imidazolylidene Catalysts for Homoenolate Annulation from Enal and Aldehyde
Published in Angewandte Chemie (19-10-2020)“…Hydrogen‐transfer in the tetrahedral intermediate generated from an imidazolylidene catalyst and α,β‐unsaturated aldehyde forms a conjugated Breslow…”
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