Search Results - "Kwon, S. Chul"

Functional Anatomy of the Human Microprocessor by Nguyen, Tuan Anh, Jo, Myung Hyun, Choi, Yeon-Gil, Park, Joha, Kwon, S. Chul, Hohng, Sungchul, Kim, V. Narry, Woo, Jae-Sung

“…MicroRNA (miRNA) maturation is initiated by Microprocessor composed of RNase III DROSHA and its cofactor DGCR8, whose fidelity is critical for generation of…”
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Uridylation by TUT4 and TUT7 Marks mRNA for Degradation by Lim, Jaechul, Ha, Minju, Chang, Hyeshik, Kwon, S. Chul, Simanshu, Dhirendra K., Patel, Dinshaw J., Kim, V. Narry

“…Uridylation occurs pervasively on mRNAs, yet its mechanism and significance remain unknown. By applying TAIL-seq, we identify TUT4 and TUT7 (TUT4/7), also…”
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Mono-Uridylation of Pre-MicroRNA as a Key Step in the Biogenesis of Group II let-7 MicroRNAs by Heo, Inha, Ha, Minju, Lim, Jaechul, Yoon, Mi-Jeong, Park, Jong-Eun, Kwon, S. Chul, Chang, Hyeshik, Kim, V. Narry

“…RNase III Drosha initiates microRNA (miRNA) maturation by cleaving a primary miRNA transcript and releasing a pre-miRNA with a 2 nt 3′ overhang. Dicer…”
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LIN28A Is a Suppressor of ER-Associated Translation in Embryonic Stem Cells by Cho, Jun, Chang, Hyeshik, Kwon, S. Chul, Kim, Baekgyu, Kim, Yoosik, Choe, Junho, Ha, Minju, Kim, Yoon Ki, Kim, V. Narry

“…LIN28 plays a critical role in developmental transition, glucose metabolism, and tumorigenesis. At the molecular level, LIN28 is known to repress maturation of…”
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Structure of Human DROSHA by Kwon, S. Chul, Nguyen, Tuan Anh, Choi, Yeon-Gil, Jo, Myung Hyun, Hohng, Sungchul, Kim, V. Narry, Woo, Jae-Sung

“…MicroRNA maturation is initiated by RNase III DROSHA that cleaves the stem loop of primary microRNA. DROSHA functions together with its cofactor DGCR8 in a…”
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Chemical RNA digestion enables robust RNA-binding site mapping at single amino acid resolution by Bae, Jong Woo, Kwon, S. Chul, Na, Yongwoo, Kim, V. Narry, Kim, Jong-Seo

“…RNA-binding sites (RBSs) can be identified by liquid chromatography and tandem mass spectrometry analyses of the protein–RNA conjugates created by…”
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Molecular Basis for the Single-Nucleotide Precision of Primary microRNA Processing by Kwon, S. Chul, Baek, S. Chan, Choi, Yeon-Gil, Yang, Jihye, Lee, Young-suk, Woo, Jae-Sung, Kim, V. Narry

“…Microprocessor, composed of DROSHA and its cofactor DGCR8, initiates microRNA (miRNA) biogenesis by processing the primary transcripts of miRNA (pri-miRNAs)…”
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FAX-RIC enables robust profiling of dynamic RNP complex formation in multicellular organisms in vivo by Na, Yongwoo, Kim, Hyunjoon, Choi, Yeon, Shin, Sanghee, Jung, Jae Hun, Kwon, S Chul, Kim, V Narry, Kim, Jong-Seo

“…Abstract RNA–protein interaction is central to post-transcriptional gene regulation. Identification of RNA-binding proteins relies mainly on UV-induced…”
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ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8 by Kwon, S Chul, Jang, Harim, Shen, Siyuan, Baek, S Chan, Kim, Kijun, Yang, Jihye, Kim, Jeesoo, Kim, Jong-Seo, Wang, Suman, Shi, Yunyu, Li, Fudong, Kim, V Narry

“…Abstract The microprocessor complex cleaves the primary transcript of microRNA (pri-miRNA) to initiate miRNA maturation. Microprocessor is known to consist of…”
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Posttranscriptional Crossregulation between Drosha and DGCR8 by Han, Jinju, Pedersen, Jakob S., Kwon, S. Chul, Belair, Cassandra D., Kim, Young-Kook, Yeom, Kyu-Hyeon, Yang, Woo-Young, Haussler, David, Blelloch, Robert, Kim, V. Narry

“…The Drosha-DGCR8 complex, also known as Microprocessor, is essential for microRNA (miRNA) maturation. Drosha functions as the catalytic subunit, while DGCR8…”
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Next-generation libraries for robust RNA interference-based genome-wide screens by Kampmann, Martin, Max A. Horlbeck, Yuwen Chen, Jordan C. Tsai, Michael C. Bassik, Luke A. Gilbert, Jacqueline E. Villalta, S. Chul Kwon, Hyeshik Chang, V. Narry Kim, Jonathan S. Weissman

“…Significance Genetic screening is a classic approach to identify genes acting in a biological process of interest. In mammalian cells, screens are commonly…”
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The RNA-binding protein repertoire of embryonic stem cells by Kwon, S Chul, Yi, Hyerim, Eichelbaum, Katrin, Föhr, Sophia, Fischer, Bernd, You, Kwon Tae, Castello, Alfredo, Krijgsveld, Jeroen, Hentze, Matthias W, Kim, V Narry

“…A mRNA-interactome capture approach in embryonic stem cells (ESCs) has led to the identification of 283 novel RNA-binding protein (RBP) candidates, of which 68…”
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Artificial primary-miRNAs as a platform for simultaneous delivery of siRNA and antisense oligonucleotide for multimodal gene regulation by Kim, Hyunsook, Jang, Bora, Lee, Dayoung, Kwon, S. Chul, Lee, Hyukjin

“…Self-assembled nucleic acid nanostructures have been widely explored for gene therapy applications due to their unique advantages. Their roles are not limited…”
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Changes in Clinical Characteristics of the Patients Who Received Endoscopic Sinus Surgery according to 10 Year Temporal Difference: A Retrospective Observational Study by Ryu, In Yong, Kwon, Chul, Koh, Tae Kyung, Lee, Kun Hee, Cho, Joong Saeng, Kim, Sung Wan

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