Search Results - "Kwon, Ronald"

Using zebrafish to study skeletal genomics by Kwon, Ronald Y., Watson, Claire J., Karasik, David

“…While genome-wide association studies (GWAS) have revolutionized our understanding of the genetic architecture of skeletal diseases, animal models are required…”
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The Reissner Fiber Is Highly Dynamic In Vivo and Controls Morphogenesis of the Spine by Troutwine, Benjamin R., Gontarz, Paul, Konjikusic, Mia J., Minowa, Ryoko, Monstad-Rios, Adrian, Sepich, Diane S., Kwon, Ronald Y., Solnica-Krezel, Lilianna, Gray, Ryan S.

“…Cerebrospinal fluid (CSF) physiology is important for the development and homeostasis of the central nervous system, and its disruption has been linked to…”
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Mechanically induced osteogenic differentiation--the role of RhoA, ROCKII and cytoskeletal dynamics by Arnsdorf, Emily J, Tummala, Padmaja, Kwon, Ronald Y, Jacobs, Christopher R

“…Many biochemical factors regulating progenitor cell differentiation have been examined in detail; however, the role of the local mechanical environment on stem…”
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Zebrafish: An Emerging Model for Orthopedic Research by Busse, Björn, Galloway, Jenna L., Gray, Ryan S., Harris, Matthew P., Kwon, Ronald Y.

“…ABSTRACT Advances in next‐generation sequencing have transformed our ability to identify genetic variants associated with clinical disorders of the…”
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Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies by Gistelinck, Charlotte, Kwon, Ronald Y., Malfait, Fransiska, Symoens, Sofie, Harris, Matthew P., Henke, Katrin, Hawkins, Michael B., Fisher, Shannon, Sips, Patrick, Guillemyn, Brecht, Bek, Jan Willem, Vermassen, Petra, De Saffel, Hanna, Witten, Paul Eckhard, Weis, MaryAnn, De Paepe, Anne, Eyre, David R., Willaert, Andy, Coucke, Paul J.

“…The type I collagenopathies are a group of heterogeneous connective tissue disorders, that are caused by mutations in the genes encoding type I collagen and…”
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Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism by Malone, Amanda M.D, Anderson, Charles T, Tummala, Padmaja, Kwon, Ronald Y, Johnston, Tyler R, Stearns, Tim, Jacobs, Christopher R

“…Primary cilia are sensory organelles that translate extracellular chemical and mechanical cues into cellular responses. Bone is an exquisitely mechanosensitive…”
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Loss of Type I Collagen Telopeptide Lysyl Hydroxylation Causes Musculoskeletal Abnormalities in a Zebrafish Model of Bruck Syndrome by Gistelinck, Charlotte, Witten, Paul Eckhard, Huysseune, Ann, Symoens, Sofie, Malfait, Fransiska, Larionova, Daria, Simoens, Pascal, Dierick, Manuel, Van Hoorebeke, Luc, De Paepe, Anne, Kwon, Ronald Y, Weis, MaryAnn, Eyre, David R, Willaert, Andy, Coucke, Paul J

“…ABSTRACT Bruck syndrome (BS) is a disorder characterized by joint flexion contractures and skeletal dysplasia that shows strong clinical overlap with the…”
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Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells by Kwon, Ronald Y, Temiyasathit, Sara, Tummala, Padmaja, Quah, Clarence C, Jacobs, Christopher R

“…Primary cilia are chemosensing and mechanosensing organelles that regulate remarkably diverse processes in a variety of cells. We previously showed that…”
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Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading by You, Lidan, Temiyasathit, Sara, Lee, Peling, Kim, Chi Hyun, Tummala, Padmaja, Yao, Wei, Kingery, Wade, Malone, Amanda M, Kwon, Ronald Y, Jacobs, Christopher R

“…Abstract Bone has the ability to adjust its structure to meet its mechanical environment. The prevailing view of bone mechanobiology is that osteocytes are…”
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Botulinum toxin A-induced muscle paralysis stimulates Hdac4 and differential miRNA expression by Worton, Leah E, Gardiner, Edith M, Kwon, Ronald Y, Downey, Leah M, Ausk, Brandon J, Bain, Steven D, Gross, Ted S

“…At sufficient dose, intramuscular injection of Botulinum toxin A causes muscle wasting that is physiologically consistent with surgical denervation and other…”
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Immigration and support for redistributive social policy: Does multiculturalism matter? by Kwon, Ronald, Curran, Michaela

“…In this article, we examine the impact of multicultural immigration policy on the degree to which immigration reduces support for redistributive social policy…”
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Shear strength behavior of human trabecular bone by Sanyal, Arnav, Gupta, Atul, Bayraktar, Harun H, Kwon, Ronald Y, Keaveny, Tony M

“…Abstract The shear strength of human trabecular bone may influence overall bone strength under fall loading conditions and failure at bone-implant interfaces…”
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Configurations of attitudes toward immigration in Europe: evidence of polarization, ambivalence, and multidimensionality by Kwon, Ronald, Scarborough, William J., Gallardo, Roberto

“…Scholarship on immigrant stereotypes suggest that individuals’ viewpoints toward immigration may be differentiated across the dimensions of culture and…”
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MicroCT-based phenomics in the zebrafish skeleton reveals virtues of deep phenotyping in a distributed organ system by Hur, Matthew, Gistelinck, Charlotte A, Huber, Philippe, Lee, Jane, Thompson, Marjorie H, Monstad-Rios, Adrian T, Watson, Claire J, McMenamin, Sarah K, Willaert, Andy, Parichy, David M, Coucke, Paul, Kwon, Ronald Y

“…Phenomics, which ideally involves in-depth phenotyping at the whole-organism scale, may enhance our functional understanding of genetic variation. Here, we…”
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Skeletal adaptation to intramedullary pressure-induced interstitial fluid flow is enhanced in mice subjected to targeted osteocyte ablation by Kwon, Ronald Y, Meays, Diana R, Meilan, Alexander S, Jones, Jeremiah, Miramontes, Rosa, Kardos, Natalie, Yeh, Jiunn-Chern, Frangos, John A

“…Interstitial fluid flow (IFF) is a potent regulatory signal in bone. During mechanical loading, IFF is generated through two distinct mechanisms that result in…”
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Computational anatomy and geometric shape analysis enables analysis of complex craniofacial phenotypes in zebrafish by Diamond, Kelly M, Rolfe, Sara M, Kwon, Ronald Y, Maga, A Murat

“…Due to the complexity of fish skulls, previous attempts to classify craniofacial phenotypes have relied on qualitative features or sparce 2D landmarks. In this…”
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Microfluidic enhancement of intramedullary pressure increases interstitial fluid flow and inhibits bone loss in hindlimb suspended mice by Kwon, Ronald Y, Meays, Diana R, Tang, W Joyce, Frangos, John A

“…Interstitial fluid flow (IFF) has been widely hypothesized to mediate skeletal adaptation to mechanical loading. Although a large body of in vitro evidence has…”
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Beta 2 Adrenergic Receptor Selective Antagonist Enhances Mechanically Stimulated Bone Anabolism in Aged Mice by E. Worton, Leah, Srinivasan, Sundar, Threet, DeWayne, Ausk, Brandon J., Huber, Phillipe, Y. Kwon, Ronald, Bain, Steven D., Gross, Ted S., M. Gardiner, Edith

“…The anabolic response of aged bone to skeletal loading is typically poor. Efforts to improve mechanotransduction in aged bone have met with limited success…”
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Human microglia show unique transcriptional changes in Alzheimer's disease by Prater, Katherine E, Green, Kevin J, Mamde, Sainath, Sun, Wei, Cochoit, Alexandra, Smith, Carole L, Chiou, Kenneth L, Heath, Laura, Rose, Shannon E, Wiley, Jesse, Keene, C Dirk, Kwon, Ronald Y, Snyder-Mackler, Noah, Blue, Elizabeth E, Logsdon, Benjamin, Young, Jessica E, Shojaie, Ali, Garden, Gwenn A, Jayadev, Suman

“…Microglia, the innate immune cells of the brain, influence Alzheimer's disease (AD) progression and are potential therapeutic targets. However, microglia…”
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Single-cell resolution of MET- and EMT-like programs in osteoblasts during zebrafish fin regeneration by Tang, W. Joyce, Watson, Claire J., Olmstead, Theresa, Allan, Christopher H., Kwon, Ronald Y.

“…Zebrafish regenerate fin rays following amputation through epimorphic regeneration, a process that has been proposed to involve the epithelial-to-mesenchymal…”
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