Search Results - "Kwon, Jason J"

A Systematic Review of miR-29 in Cancer by Kwon, Jason J., Factora, Tricia D., Dey, Shatovisha, Kota, Janaiah

“…MicroRNAs (miRNA) are small non-coding RNAs (∼22 nt in length) that are known as potent master regulators of eukaryotic gene expression. miRNAs have been shown…”
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Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential by Kwon, Jason J, Willy, Jeffrey A, Quirin, Kayla A, Wek, Ronald C, Korc, Murray, Yin, Xiao-Ming, Kota, Janaiah

“…Pancreatic Ductal Adenocarcinoma (PDAC) is a highly lethal malignancy that responds poorly to current therapeutic modalities. In an effort to develop novel…”
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Loss of miR-29a/b1 promotes inflammation and fibrosis in acute pancreatitis by Dey, Shatovisha, Udari, Lata M, RiveraHernandez, Primavera, Kwon, Jason J, Willis, Brandon, Easler, Jeffrey J, Fogel, Evan L, Pandol, Stephen, Kota, Janaiah

“…MicroRNA-29 (miR-29) is a critical regulator of fibroinflammatory processes in human diseases. In this study, we found a decrease in miR-29a in experimental…”
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Target-driven machine learning-enabled virtual screening (TAME-VS) platform for early-stage hit identification by Bian, Yuemin, Kwon, Jason J, Liu, Cong, Margiotta, Enrico, Shekhar, Mrinal, Gould, Alexandra E

“…High-throughput screening (HTS) methods enable the empirical evaluation of a large scale of compounds and can be augmented by virtual screening (VS) techniques…”
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VRK1 as a synthetic lethal target in VRK2 promoter-methylated cancers of the nervous system by So, Jonathan, Mabe, Nathaniel W, Englinger, Bernhard, Chow, Kin-Hoe, Moyer, Sydney M, Yerrum, Smitha, Trissal, Maria C, Marques, Joana G, Kwon, Jason J, Shim, Brian, Pal, Sangita, Panditharatna, Eshini, Quinn, Thomas, Schaefer, Daniel A, Jeong, Daeun, Mayhew, David L, Hwang, Justin, Beroukhim, Rameen, Ligon, Keith L, Stegmaier, Kimberly, Filbin, Mariella G, Hahn, William C

“…Collateral lethality occurs when loss of a gene/protein renders cancer cells dependent on its remaining paralog. Combining genome-scale CRISPR/Cas9…”
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A Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective by Kwon, Jason J., Hahn, William C.

“…SHOC2 is a prototypical leucine-rich repeat protein that promotes downstream receptor tyrosine kinase (RTK)/RAS signaling and plays important roles in several…”
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Safety and Efficacy of AAV Retrograde Pancreatic Ductal Gene Delivery in Normal and Pancreatic Cancer Mice by Quirin, Kayla A, Kwon, Jason J, Alioufi, Arafat, Factora, Tricia, Temm, Constance J, Jacobsen, Max, Sandusky, George E, Shontz, Kim, Chicoine, Louis G, Clark, K Reed, Mendell, Joshua T, Korc, Murray, Kota, Janaiah

“…Recombinant adeno-associated virus (rAAV)-mediated gene delivery shows promise to transduce the pancreas, but safety/efficacy in a neoplastic context is not…”
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miR-29a Is Repressed by MYC in Pancreatic Cancer and Its Restoration Drives Tumor-Suppressive Effects via Downregulation of LOXL2 by Dey, Shatovisha, Kwon, Jason J, Liu, Sheng, Hodge, Gabriel A, Taleb, Solaema, Zimmers, Teresa A, Wan, Jun, Kota, Janaiah

“…Pancreatic ductal adenocarcinoma (PDAC) is an intractable cancer with a dismal prognosis. miR-29a is commonly downregulated in PDAC; however, mechanisms for…”
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Structure–function analysis of the SHOC2–MRAS–PP1C holophosphatase complex by Kwon, Jason J., Hajian, Behnoush, Bian, Yuemin, Young, Lucy C., Amor, Alvaro J., Fuller, James R., Fraley, Cara V., Sykes, Abbey M., So, Jonathan, Pan, Joshua, Baker, Laura, Lee, Sun Joo, Wheeler, Douglas B., Mayhew, David L., Persky, Nicole S., Yang, Xiaoping, Root, David E., Barsotti, Anthony M., Stamford, Andrew W., Perry, Charles K., Burgin, Alex, McCormick, Frank, Lemke, Christopher T., Hahn, William C., Aguirre, Andrew J.

“…Receptor tyrosine kinase (RTK)–RAS signalling through the downstream mitogen-activated protein kinase (MAPK) cascade regulates cell proliferation and survival…”
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On knowing a gene: A distributional hypothesis of gene function by Kwon, Jason J, Pan, Joshua, Gonzalez, Guadalupe, Hahn, William C, Zitnik, Marinka

“…As words can have multiple meanings that depend on sentence context, genes can have various functions that depend on the surrounding biological system. This…”
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Pathophysiological role of microRNA-29 in pancreatic cancer stroma by Kwon, Jason J., Nabinger, Sarah C., Vega, Zachary, Sahu, Smiti Snigdha, Alluri, Ravi K., Abdul-Sater, Zahi, Yu, Zhangsheng, Gore, Jesse, Nalepa, Grzegorz, Saxena, Romil, Korc, Murray, Kota, Janaiah

“…Dense fibrotic stroma associated with pancreatic ductal adenocarcinoma (PDAC) is a major obstacle for drug delivery to the tumor bed and plays a crucial role…”
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Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers by Sulahian, Rita, Kwon, Jason J., Walsh, Katherine H., Pailler, Emma, Bosse, Timothy L., Thaker, Maneesha, Almanza, Diego, Dempster, Joshua M., Pan, Joshua, Piccioni, Federica, Dumont, Nancy, Gonzalez, Alfredo, Rennhack, Jonathan, Nabet, Behnam, Bachman, John A., Goodale, Amy, Lee, Yenarae, Bagul, Mukta, Liao, Rosy, Navarro, Adrija, Yuan, Tina L., Ng, Raymond W.S., Raghavan, Srivatsan, Gray, Nathanael S., Tsherniak, Aviad, Vazquez, Francisca, Root, David E., Firestone, Ari J., Settleman, Jeff, Hahn, William C., Aguirre, Andrew J.

“…The mitogen-activated protein kinase (MAPK) pathway is a critical effector of oncogenic RAS signaling, and MAPK pathway inhibition may be an effective…”
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Sparse dictionary learning recovers pleiotropy from human cell fitness screens by Pan, Joshua, Kwon, Jason J, Talamas, Jessica A, Borah, Ashir A, Vazquez, Francisca, Boehm, Jesse S, Tsherniak, Aviad, Zitnik, Marinka, McFarland, James M, Hahn, William C

“…In high-throughput functional genomic screens, each gene product is commonly assumed to exhibit a singular biological function within a defined protein complex…”
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Abstract 769: Mechanistic role of miR-29 in pancreatic ductal adenocarcinoma progression by Dey, Shatovisha, Kwon, Jason J., Liu, Sheng, Factoria, Tricia, Hodge, Gabriel A., Wan, Jun, Kota, Janaiah

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with a 5-year survival rate of 8% (Kota et al., 2017, Cancer Lett.)…”
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Abstract LB-327: Restoration of MYC-repressed miR-29 in pancreatic cancer cells leads to increased reactive oxygen species and gemcitabine sensitization by Kwon, Jason J., Quirin, Kayla, Aljoufi, Arafat, Nafiseh, Amira, Kota, Janaiah

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) still remains to be one of the most highly malignant human diseases and is resistant to the majority of…”
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Abstract 172: Pathophysiological role of microRNA-29 in pancreatic cancer stroma by Kwon, Jason J., Nabinger, Sarah C., Alluri, Ravi K., Vega, Zachary, Sahu, Smiti S., Abdul Sater, Zahi, Yu, Zhangsheng, Gore, A Jesse, Nalepa, Grzegorz, Saxena, Romil, Korc, Murray, Kota, Janaiah

“…Abstract Dense fibrotic stroma associated with pancreatic ductal adenocarcinoma (PDAC) has been a major obstacle for drug delivery to the tumor bed and may…”
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Sparse dictionary learning recovers pleiotropy from human cell fitness screens by Pan, Joshua, Kwon, Jason J, Talamas, Jessica A, Borah, Ashir A, Vazquez, Francisca, Boehm, Jesse S, Tsherniak, Aviad, Zitnik, Marinka, McFarland, James M, Hahn, William C

“…In high-throughput functional genomic screens, each gene product is commonly assumed to exhibit a singular biological function within a defined protein complex…”
Get full text