Search Results - "Kwon, Hyunjoo"

Yes‐Associated Protein in Kupffer Cells Enhances the Production of Proinflammatory Cytokines and Promotes the Development of Nonalcoholic Steatohepatitis by Song, Kyoungsub, Kwon, Hyunjoo, Han, Chang, Chen, Weina, Zhang, Jinqiang, Ma, Wenbo, Dash, Srikanta, Gandhi, Chandrashekhar R., Wu, Tong

“…Background and Aims Yes‐associated protein (YAP) plays an important role in hepatocarcinogenesis, although the potential role of YAP in non‐neoplastic liver…”
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Epigenetic Silencing of miRNA-34a in Human Cholangiocarcinoma via EZH2 and DNA Methylation by Kwon, Hyunjoo, Song, Kyoungsub, Han, Chang, Zhang, Jinqiang, Lu, Lu, Chen, Weina, Wu, Tong

“…Aberrant expression and regulation of miRNAs have been implicated in multiple stages of tumorigenic processes. The current study was designed to explore the…”
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Epigenetic Silencing of miRNA-34a in Human Cholangiocarcinoma via EZH2 and DNA Methylation: Impact on Regulation of Notch Pathway by Kwon, Hyunjoo, Song, Kyoungsub, Han, Chang, Zhang, Jinqiang, Lu, Lu, Chen, Weina, Wu, Tong

“…Aberrant expression and regulation of miRNAs have been implicated in multiple stages of tumorigenic processes. The current study was designed to explore the…”
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The Histone Methyltransferase G9a Promotes Cholangiocarcinogenesis Through Regulation of the Hippo Pathway Kinase LATS2 and YAP Signaling Pathway by Ma, Wenbo, Han, Chang, Zhang, Jinqiang, Song, Kyoungsub, Chen, Weina, Kwon, Hyunjoo, Wu, Tong

“…Background and Aims Cholangiocarcinoma (CCA) is a highly malignant epithelial tumor of the biliary tree with poor prognosis. In the current study, we present…”
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Inhibition of hedgehog signaling ameliorates hepatic inflammation in mice with nonalcoholic fatty liver disease by Kwon, Hyunjoo, Song, Kyoungsub, Han, Chang, Chen, Weina, Wang, Ying, Dash, Srikanta, Lim, Kyu, Wu, Tong

“…Hedgehog (Hh) signaling plays a critical role in liver development, regeneration, injury repair, and carcinogenesis. Activation of Hh signaling has been…”
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A Transforming Growth Factor‐β and H19 Signaling Axis in Tumor‐Initiating Hepatocytes That Regulates Hepatic Carcinogenesis by Zhang, Jinqiang, Han, Chang, Ungerleider, Nathan, Chen, Weina, Song, Kyoungsub, Wang, Ying, Kwon, Hyunjoo, Ma, Wenbo, Wu, Tong

“…Functions of transforming growth factor‐β (TGF‐β) in the liver vary depending on specific cell types and their temporal response to TGF‐β during different…”
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EZH2 Promotes Cholangiocarcinoma Development and Progression through Histone Methylation and microRNA-Mediated Down-Regulation of Tumor Suppressor Genes by Zhang, Jinqiang, Chen, Weina, Ma, Wenbo, Han, Chang, Song, Kyoungsub, Kwon, Hyunjoo, Wu, Tong

“…Cholangiocarcinoma (CCA) is a highly malignant cancer of the biliary tree. Although studies have implicated enhancer of Zeste homolog 2 (EZH2) in CCA growth,…”
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Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122 by Song, Kyoungsub, Kwon, Hyunjoo, Han, Chang, Zhang, Jinqiang, Dash, Srikanta, Lim, Kyu, Wu, Tong

“…Although altered metabolic pathway is an important diagnostic maker and therapeutic target in cancer, it is poorly understood in cancer stem cells (CSCs). Here…”
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HM15912, a Novel Long-Acting Glucagon-Like Peptide-2 Analog, Improves Intestinal Growth and Absorption Capacity in a Male Rat Model of Short Bowel Syndrome by Choi, Jaehyuk, Lee, Jinbong, Park, Eunjin, Kwon, Hyunjoo, Kim, Daejin, Bae, Sungmin, Choi, In Young, Kim, Ha Hyung

“…Extensive bowel resection caused by various diseases that affect the intestines, such as Crohn's disease, volvulus, and cancer, leads to short bowel syndrome…”
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WED-437 - Anti-inflammatory and anti-fibrotic effects by simultaneous activation of glucagon, GIP, and GLP-1 of efocipegtrutide (HM15211) in thioacetamide-induced mouse model of liver injury and fibrosis by Kim, Jung Kuk, Kim, Yohan, Lee, Jong Suk, Kwon, Hyunjoo, Park, Eun Jin, Kim, Jeong A, Bae, Sung Min, Kim, Dae Jin, Lee, Sang Hyun, Choi, In Young

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Anti-inflammatory and anti-fibrotic effects by simultaneous activation of glucagon, GIP, and GLP-1 of efocipegtrutide (HM15211) in thioacetamide-induced mouse model of liver injury and fibrosis by Kim, Jung Kuk, Kim, Yohan, Lee, Jong Suk, Kwon, Hyunjoo, Park, Eun Jin, Kim, Jeong A, Bae, Sung Min, Kim, Dae Jin, Lee, Sang Hyun, Choi, In Young

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Improvement of liver fibrosis by a novel long acting Glucagon/GLP-1/GIP triple agonist, efocipegtrutide (HM15211) in carbon tetrachloride-induced mouse model of liver injury and fibrosis by Lee, Jong Suk, Kim, Yohan, Kim, Jung Kuk, Kwon, Hyunjoo, Park, Eun Jin, Kim, Jeong A, Park, Sang Hyun, Bae, Sung Min, Lee, Sang Hyun, Choi, In Young

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WED-473 - Improvement of liver fibrosis by a novel long acting Glucagon/GLP-1/GIP triple agonist, efocipegtrutide (HM15211) in carbon tetrachloride-induced mouse model of liver injury and fibrosis by Lee, Jong Suk, Kim, Yohan, Kim, Jung Kuk, Kwon, Hyunjoo, Park, Eun Jin, Kim, Jeong A, Park, Sang Hyun, Bae, Sung Min, Lee, Sang Hyun, Choi, In Young

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Yes‐associated protein (YAP) in Kupffer cells enhances the production of pro‐inflammatory cytokines and promotes the development of non‐alcoholic steatohepatitis by Song, Kyoungsub, Kwon, Hyunjoo, Han, Chang, Zhang, Jinqiang, Chen, Weina, Ma, Wenbo, Wu, Tong

“…Abstract only…”
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The Histone Methyltransferase G9a Promotes Cholangiocarcinogenesis through Regulation of the Hippo Pathway Kinase LATS2 and YAP Signaling Pathway by Ma, Wenbo, Han, Chang, Zhang, Jinqiang, Song, Kyoungsub, Chen, Weina, Kwon, Hyunjoo, Wu, Tong

“…Abstract only…”
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655-P: Multitarget Engagement Effect of a Novel Long-Acting Glucagon/GIP/GLP-1 Triple Agonist (HM15211) in Animal Model of NASH by KIM, JUNG KUK, LEE, JONG SUK, KWON, HYUNJOO, PARK, EUNJIN, LEE, JONGSOO, BAE, SUNGMIN, LEE, SANG HYUN, CHOI, IN YOUNG

“…NASH is a complex disease progressed by multiple mechanism. To date, no approved drug is available due to unsatisfied efficacy. Of note, recent studies…”
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Multi-target engagement effect of a novel long-acting Glucagon/ GIP/GLP-1 triple agonist, HM15211, in animal model of NASH/ fibrosis by Lee, Jong Suk, Kim, Jung Kuk, Lee, Seonmyeong, Kim, Yohan, Choi, Jaehyuk, Kwon, Hyunjoo, Park, Eun Jin, Bae, Sung Min, Lee, Sang Hyun, Choi, In Young

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Adult Hepatocytes Are Hedgehog-Responsive Cells in the Setting of Liver Injury: Evidence for Smoothened-Mediated Activation of NF-κB/Epidermal Growth Factor Receptor/Akt in Hepatocytes that Counteract Fas-Induced Apoptosis by Wang, Ying, Chen, Weina, Han, Chang, Zhang, Jinqiang, Song, Kyoungsub, Kwon, Hyunjoo, Dash, Srikanta, Yao, Lu, Wu, Tong

“…Although hedgehog (Hh) signaling pathway is inactive in adult healthy liver, it becomes activated during acute and chronic liver injury and, thus, modulates…”
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1830-P: Therapeutic Effect of a Novel Long-Acting GLP-1/GIP/Glucagon Triple Agonist (HM15211) in CDHFD-Induced NASH and Fibrosis Mice by CHOI, JAEHYUK, KIM, JUNG KUK, LEE, SEON MYEONG, KWON, HYUNJOO, LEE, JONGSOO, BAE, SUNGMIN, KIM, DAEJIN, CHOI, IN YOUNG

“…Nonalcoholic steatohepatitis (NASH) is a progressive liver disease characterized by steatosis and inflammation, which results in fibrosis. In particular,…”
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YAP in Kupffer cells enhances the production of pro-inflammatory cytokines and promotes the development of non-alcoholic steatohepatitis by Song, Kyoungsub, Kwon, Hyunjoo, Han, Chang, Chen, Weina, Zhang, Janqiang, Ma, Wenbo, Dash, Srikanta, Gandhi, Chandrashekhar R., Wu, Tong

“…Yes-associated protein (YAP) plays an important role in hepatocarcinogenesis, although the potential role of YAP in non-neoplastic liver diseases remains…”
Get full text