Search Results - "Kwon, Hyeok Yil"

Tat-CIAPIN1 protein prevents against cytokine-induced cytotoxicity in pancreatic RINm5Fβ-cells by Yeo, Hyeon Ji, Shin, Min Jea, Kim, Dae Won, Kwon, Hyeok Yil, Eum, Won Sik, Choi, Soo Young

“…Cytokines activate inflammatory signals and are major mediators in progressiveβ-cell damage, which leads to type 1 diabetes mellitus. We recently showed that…”
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In vivo protein transduction: biologically active intact pep-1-superoxide dismutase fusion protein efficiently protects against ischemic insult by Sik Eum, Won, Won Kim, Dae, Koo Hwang, In, Yoo, Ki-Yeon, Kang, Tae-Cheon, Ho Jang, Sang, Soon Choi, Hee, Hyun Choi, Soo, Hoon Kim, Young, Young Kim, So, Yil Kwon, Hyeok, Hoon Kang, Jung, Kwon, Oh-Shin, Cho, Sung-Woo, Soo Lee, Kil, Park, Jinseu, Ho Won, Moo, Young Choi, Soo

“…Reactive oxygen species (ROS) are implicated in reperfusion injury after transient focal cerebral ischemia. The antioxidant enzyme Cu,Zn-superoxide dismutase…”
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MicroRNA-22 negatively regulates LPS-induced inflammatory responses by targeting HDAC6 in macrophages by Youn, Gi Soo, Park, Jong Kook, Lee, Chae Yeon, Jang, Jae Hee, Yun, Sang Ho, Kwon, Hyeok Yil, Choi, Soo Young, Park, Jinseu

“…Dysregulation of histone deacetylase 6 (HDAC6) can lead to the pathologic states and result in the development of various diseases including cancers and…”
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PEP-1-paraoxonase 1 fusion protein prevents cytokine-induced cell destruction and impaired insulin secretion in rat insulinoma cells by Lee, Su Jin, Kang, Hyung Kyung, Choi, Yeon Joo, Eum, Won Sik, Park, Jinseu, Choi, Soo Young, Kwon, Hyeok Yil

“…Pancreatic beta cell destruction and dysfunction induced by cytokines is a major cause of type 1 diabetes. Paraoxonase 1 (PON1), an arylesterase with…”
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Protective effects of Tat-DJ-1 protein against streptozotocin-induced diabetes in a mice model by Yeo, Hyeon Ji, Yeo, Eun Ji, Shin, Min Jea, Choi, Yeon Joo, Lee, Chi Hern, Kwon, Hyeok Yil, Kim, Dae Won, Eum, Won Sik, Choi, Soo Young

“…A major feature of type 1 diabetes mellitus (T1DM) is hyperglycemia and dysfunction of pancreatic β-cells. In a previous study, we have shown that Tat-DJ-1…”
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2,3-Dimethoxy-2`-hydroxychalcone ameliorates TNF-α-induced ICAM-1 expression and subsequent monocyte adhesiveness via NF-kappaB inhibition and HO-1 induction in HaCaT cells by Kim, Hyejin, Youn, Gi Soo, An, Soo Yeon, Kwon, Hyeok Yil, Choi, Soo Young, Park, Jinseu

“…Up-regulation of adhesion molecules plays an important role in the infiltration of leukocytes into the skin during the developmentof various inflammatory skin…”
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MicroRNA-22 negatively regulates LPS-induced inflammatory responses by targeting HDAC6 in macrophages by Youn, Gi Soo, Park, Jong Kook, Lee, Chae Yeon, Jang, Jae Hee, Yun, Sang Ho, Kwon, Hyeok Yil, Choi, Soo Young, Park, Jinseu

“…Dysregulation of histone deacetylase 6 (HDAC6) can lead to the pathologic states and result in the development of various diseases including cancers and…”
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β-arrestin 2-dependent activation of ERK1/2 is required for ADP-induced paxillin phosphorylation at Ser(83) and microglia chemotaxis by Lee, Sang-Hyun, Hollingsworth, Ryan, Kwon, Hyeok-Yil, Lee, Narae, Chung, Chang Y

“…Microglia play crucial roles in increased inflammation in the central nervous system upon brain injuries and diseases. Extracellular ADP has been reported to…”
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The effects of PEP-1-FK506BP on dry eye disease in a rat model by Kim, Dae Won, Lee, Sung Ho, Ku, Sae Kwang, Lee, Ji Eun, Cha, Hyun Ju, Youn, Jong Kyu, Kwon, Hyeok Yil, Park, Jong Hoon, Park, Eun Young, Cho, Sung-Woo, Han, Kyu Hyung, Park, Jinseu, Eum, Won Sik, Choi, Soo Young

“…As FK506 binding proteins (FK506BPs) are known to play an important role in the regulation of a variety of biological processes related to cell survival, this…”
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Protective effects of PEP-1-Catalase on stress-induced cellular toxicity and MPTP-induced Parkinson`s disease by Eom, Seon Ae, Kim, Dae Won, Shin, Min Jea, Ahn, Eun Hee, Chung, Seok Young, Sohn, Eun Jeong, Jo, Hyo Sang, Jeon, Su-Jeong, Kim, Duk-Soo, Kwon, Hyeok Yil, Cho, Sung-Woo, Han, Kyu Hyung, Park, Jinseu, Eum, Won Sik, Choi, Soo Young

“…Parkinson’s disease (PD) is a neurodegenerative disability caused by a decrease of dopaminergic neurons in the substantia nigra (SN). Although the etiology of…”
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Tat‐biliverdin reductase A protects INS‐1 cells from human islet amyloid polypeptide‐induced cytotoxicity by alleviating oxidative stress and ER stress by Lee, Su Jin, Kang, Hyung Kyung, Eum, Won Sik, Park, Jinseu, Choi, Soo Young, Kwon, Hyeok Yil

“…Human islet amyloid polypeptide (hIAPP), a major constituent of islet amyloid deposits, induces pancreatic β‐cell apoptosis and eventually contributes to…”
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Carnosine and related dipeptides protect human ceruloplasmin against peroxyl radical-mediated modification by Kang, Jung Hoon, Kim, Kyung Sik, Choi, Soo Young, Kwon, Hyeok Yil, Won, Moo Ho, Kang, Tae-Cheon

“…Ceruloplasmin (CP) is the major plasma antioxidant and copper transport protein. In a previous study, we showed that the aggregation of human ceruloplasmin was…”
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Involvement of small GTPase RhoA in the regulation of superoxide production in BV2 cells in response to fibrillar Aβ peptides by Moon, Mi-Young, Kim, Hee-Jun, Li, Yi, Kim, Jae-Gyu, Jeon, Yee-Jin, Won, Ha-Young, Kim, Jun-Sub, Kwon, Hyeok-Yil, Choi, Ihn-Geun, Ro, Eusun, Joe, Eun-Hye, Choe, Myeon, Kwon, Hyung-Joo, Kim, Hyoung-Chun, Kim, Yong-Sun, Park, Jae-Bong

“…Fibrillar amyloid-beta (fAβ) peptide causes neuronal cell death, which is known as Alzheimer's disease. One of the mechanisms for neuronal cell death is the…”
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β-arrestin 2-dependent activation of ERK1/2 is required for ADP-induced paxillin phosphorylation at Ser83 and microglia chemotaxis by Lee, Sang-Hyun, Hollingsworth, Ryan, Kwon, Hyeok-Yil, Lee, Narae, Chung, Chang Y.

“…Microglia play crucial roles in increased inflammation in the central nervous system upon brain injuries and diseases. Extracellular ADP has been reported to…”
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Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein by Lee, Sun-Hwa, Kim, Dae-Won, Eom, Seon-Ae, Jun, Se-Young, Park, Mee-Young, Kim, Duk-Soo, Kwon, Hyung-Joo, Kwon, Hyeok-Yil, Han, Kyu-Hyung, Park, Jin-Seu, Hwang, Hyun-Sook, Eum, Won-Sik, Choi, Soo-Young

“…We examined that the protective effects of ANX1 on 12-O-tetradecanoylphorbol- 13-acetate (TPA)-induced skin inflammation in animal models using a Tat-ANX1…”
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Adjuvant effect of Liposome-encapsulated natural phosphodiester CpG-DNA by Kim, Dong-Bum, Kwon, Sang-Hoon, Ahn, Chi-Seok, Lee, Young-Hee, Choi, Soo-Young, Park, Jin-Seu, Kwon, Hyeok-Yil, Kwon, Hyung-Joo

“…Immunostimulatory CpG-DNA targeting TLR9 is one of the most extensively evaluated vaccine adjuvants. Previously, we found that a particular form of natural…”
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The Stimulatory Effect of Essential Fatty Acids on Glucose Uptake Involves Both Akt and AMPK Activation in C2C12 Skeletal Muscle Cells by Park, So Yeon, Kim, Min Hye, Ahn, Joung Hoon, Lee, Su Jin, Lee, Jong Ho, Eum, Won Sik, Choi, Soo Young, Kwon, Hyeok Yil

“…Essential fatty acid (EFA) is known to be required for the body to function normally and healthily. However, the effect of EFA on glucose uptake in skeletal…”
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Protective Effects of Oleic Acid Against Palmitic Acid-Induced Apoptosis in Pancreatic AR42J Cells and Its Mechanisms by Ahn, Joung Hoon, Kim, Min Hye, Kwon, Hyung Joo, Choi, Soo Young, Kwon, Hyeok Yil

“…Palmitic acid (PAM), one of the most common saturated fatty acid (SFA) in animals and plants, has been shown to induce apoptosis in exocrine pancreatic AR42J…”
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Effects of lipopolysaccharide and CpG-DNA on burn-induced skin injury by Park, Byoung-Kwon, Kim, Dong-Bum, Cho, Sun-Hee, Seo, Jae-Nam, Park, Jae-Bong, Kim, Yong-Sun, Choi, Ihn-Geun, Kwon, Hyeok-Yil, Lee, Young-Hee, Kwon, Hyung-Joo

“…Destruction of the skin barrier by thermal injury induces microbial invasion, which can lead to the development of systemic infection and septic shock…”
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Transduction efficacy of Tat-Cu,Zn-superoxide dismutase is enhanced by copper ion recovery of the fusion protein by Eum, Won Sik, Choung, In Soon, Kim, A Yeon, Lee, Yong Je, Kang, Jung Hoon, Park, Jinseu, Lee, Kil Soo, Kwon, Hyeok Yil, Choi, Soo Young

“…We previously reported that Tat-Cu,Zn-superoxide dismutase (Tat-SOD) can be directly transduced into mammalian cells across the lipid membrane barrier. To…”
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