Search Results - "Kwon, Chang Hyuk"

Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression by Larson, Jon D., Kasper, Lawryn H., Paugh, Barbara S., Jin, Hongjian, Wu, Gang, Kwon, Chang-Hyuk, Fan, Yiping, Shaw, Timothy I., Silveira, André B., Qu, Chunxu, Xu, Raymond, Zhu, Xiaoyan, Zhang, Junyuan, Russell, Helen R., Peters, Jennifer L., Finkelstein, David, Xu, Beisi, Lin, Tong, Tinkle, Christopher L., Patay, Zoltan, Onar-Thomas, Arzu, Pounds, Stanley B., McKinnon, Peter J., Ellison, David W., Zhang, Jinghui, Baker, Suzanne J.

“…Diffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brainstem tumors with frequent histone H3 K27M mutations and recurrent alterations in PDGFRA…”
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Detoxification of oxidative stress in glioma stem cells: Mechanism, clinical relevance, and therapeutic development by Kim, Sung-Hak, Kwon, Chang-Hyuk, Nakano, Ichiro

“…Neural oncogenesis is currently incurable and invariably lethal. The development of innovative treatments for this devastating cancer will require a deeper…”
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Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model by Alcantara Llaguno, Sheila, Chen, Jian, Kwon, Chang-Hyuk, Jackson, Erica L., Li, Yanjiao, Burns, Dennis K., Alvarez-Buylla, Arturo, Parada, Luis F.

“…Malignant astrocytomas are infiltrative and incurable brain tumors. Despite profound therapeutic implications, the identity of the cell (or cells) of origin…”
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Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma by FENGTING YAN, ALINARI, Lapo, JACOB, Naduparambil K, CHAKRAVARTI, Arnab, NOWICKI, Michal O, XIN WU, LAPALOMBELLA, Rosa, DATTA, Jharna, BO YU, GORDON, Kate, HASELEY, Amy, PATTON, John T, LUSTBERG, Mark E, SMITH, Porsha L, RYU, John, XIAOLI ZHANG, XIAOKUI MO, MARCUCCI, Guido, NUOVO, Gerard, KWON, Chang-Hyuk, BYRD, John C, CHIOCCA, E. Antonio, CHENGLONG LI, MARTIN, Ludmila Katherine, SIF, Said, JACOB, Samson, LAWLER, Sean, KAUR, Balveen, BAIOCCHI, Robert A, CORDERO-NIEVES, Hector M, BANASAVADI-SIDDEGOWDA, Yeshavanth, VIRK, Selene, BARNHOLTZ-SLOAN, Jill, BELL, Erica Hlavin, WOJTON, Jeffrey

“…Glioblastoma is the most common and aggressive histologic subtype of brain cancer with poor outcomes and limited treatment options. Here, we report the…”
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Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression by Kozono, David, Jie Li, Masayuki Nitta, Oltea Sampetrean, David Gonda, Deepa S. Kushwaha, Dmitry Merzon, Valya Ramakrishnan, Shan Zhu, Kaya Zhu, Hiroko Matsui, Olivier Harismendy, Wei Hua, Ying Mao, Chang-Hyuk Kwon, Hideyuki Saya, Ichiro Nakano, Donald P. Pizzo, Scott R. VandenBerg, Clark C. Chen

“…The available evidence suggests that the lethality of glioblastoma is driven by small subpopulations of cells that self-renew and exhibit tumorigenicity. It…”
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MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells by Peruzzi, Pierpaolo, Bronisz, Agnieszka, Nowicki, Michal O, Wang, Yan, Ogawa, Daisuke, Price, Richard, Nakano, Ichiro, Kwon, Chang-Hyuk, Hayes, Josie, Lawler, Sean E, Ostrowski, Michael C, Chiocca, E Antonio, Godlewski, Jakub

“…The Polycomb Repressor Complex (PRC) is an epigenetic regulator of transcription whose action is mediated by 2 protein complexes, PRC1 and PRC2. PRC is…”
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Pten haploinsufficiency accelerates formation of high-grade astrocytomas by Kwon, Chang-Hyuk, Zhao, Dawen, Chen, Jian, Alcantara, Sheila, Li, Yanjiao, Burns, Dennis K, Mason, Ralph P, Lee, Eva Y-H P, Wu, Hong, Parada, Luis F

“…We previously reported that central nervous system (CNS) inactivation of Nf1 and p53 tumor suppressor genes in mice results in the development of low-grade to…”
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Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells by Kim, Tae Hyong, Song, Jieun, Kim, Sung-Hak, Parikh, Arav Krishnavadan, Mo, Xiaokui, Palanichamy, Kamalakannan, Kaur, Balveen, Yu, Jianhua, Yoon, Sung Ok, Nakano, Ichiro, Kwon, Chang-Hyuk

“…Piperlongumine, a natural plant product, kills multiple cancer types with little effect on normal cells. Piperlongumine raises intracellular levels of reactive…”
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Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex by Guvenc, Hacer, Pavlyukov, Marat S, Joshi, Kaushal, Kurt, Habibe, Banasavadi-Siddegowda, Yeshavanth K, Mao, Ping, Hong, Christopher, Yamada, Ryosuke, Kwon, Chang-Hyuk, Bhasin, Deepak, Chettiar, Somsundaram, Kitange, Gaspar, Park, In-Hee, Sarkaria, Jann N, Li, Chenglong, Shakhparonov, Mihail I, Nakano, Ichiro

“…Glioblastoma multiforme (GBM) is a devastating disease. Recent studies suggest that the stem cell properties of GBM contribute to the development of therapy…”
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Inducible site-specific recombination in neural stem/progenitor cells by Chen, Jian, Kwon, Chang-Hyuk, Lin, Lu, Li, Yanjiao, Parada, Luis F.

“…To establish a genetic tool for manipulating the neural stem/progenitor cell (NSC) lineage in a temporally controlled manner, we generated a transgenic mouse…”
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mTor Is Required for Hypertrophy of Pten-Deficient Neuronal Soma in vivo by Kwon, Chang-Hyuk, Zhu, Xiaoyan, Zhang, Junyuan, Baker, Suzanne J.

“…The mechanisms that regulate mammalian cell size during development and homeostatic maintenance are poorly understood. The tumor suppressor Pten is required…”
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Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth by Kim, Tae Hyong, Song, Jieun, Alcantara Llaguno, Sheila R, Murnan, Eric, Liyanarachchi, Sandya, Palanichamy, Kamalakannan, Yi, Ji-Yeun, Viapiano, Mariano Sebastian, Nakano, Ichiro, Yoon, Sung Ok, Wu, Hong, Parada, Luis F, Kwon, Chang-Hyuk

“…Glioblastoma multiforme (GBM), the most common and aggressive primary brain malignancy, is incurable despite the best combination of current cancer therapies…”
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Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo by FRASER, Melissa M, XIAOYAN ZHU, KWON, Chang-Hyuk, UHLMANN, Erik J, GUTMANN, David H, BAKER, Suzanne J

“…Somatic mutations of PTEN are found in many types of cancers including glioblastoma, the most malignant astrocytic tumor. PTEN mutation occurs in 25 to 40% of…”
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Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease by Baker, Suzanne J, Kwon, Chang-Hyuk, Zhu, Xiaoyan, Zhang, Junyuan, Knoop, Lori L, Tharp, Ruby, Smeyne, Richard J, Eberhart, Charles G, Burger, Peter C

“…Somatic inactivation of PTEN occurs in different human tumors including glioblastoma, endometrial carcinoma and prostate carcinoma. Germline mutations in PTEN…”
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Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma by Li, Jie, Zhu, Shan, Kozono, David, Ng, Kimberly, Futalan, Diahnn, Shen, Ying, Akers, Johnny C., Steed, Tyler, Kushwaha, Deepa, Schlabach, Michael, Carter, Bob S., Kwon, Chang-Hyuk, Furnari, Frank, Cavenee, Webster, Elledge, Stephen, Chen, Clark C.

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Neurofibromin Is Required for Barrel Formation in the Mouse Somatosensory Cortex by Lush, Mark E, Li, Yun, Kwon, Chang-Hyuk, Chen, Jian, Parada, Luis F

“…The rodent barrel cortex is a useful system to study the role of genes and neuronal activity in the patterning of the nervous system. Several genes encoding…”
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TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment by Li, Yun, Luikart, Bryan W., Birnbaum, Shari, Chen, Jian, Kwon, Chang-Hyuk, Kernie, Steven G., Bassel-Duby, Rhonda, Parada, Luis F.

“…Adult hippocampal neurogenesis is stimulated by chronic administration of antidepressants (ADs) and by voluntary exercise. Neural progenitor cells (NPCs) in…”
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Pten Regulates Neuronal Arborization and Social Interaction in Mice by Kwon, Chang-Hyuk, Luikart, Bryan W., Powell, Craig M., Zhou, Jing, Matheny, Sharon A., Zhang, Wei, Li, Yanjiao, Baker, Suzanne J., Parada, Luis F.

“…CNS deletion of Pten in the mouse has revealed its roles in controlling cell size and number, thus providing compelling etiology for macrocephaly and…”
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Genetic Modification of T Cells Redirected toward CS1 Enhances Eradication of Myeloma Cells by JIANHONG CHU, SHUN HE, XIAOMING HE, BAI, Xue-Feng, HOFMEISTER, Craig C, JIANHUA YU, YOUCAI DENG, JIANYING ZHANG, YONG PENG, HUGHES, Tiffany, LING YI, KWON, Chang-Hyuk, WANG, Qi-En, DEVINE, Steven M

“…Our goal is to test whether CS1 could be targeted by chimeric antigen receptor (CAR) T cells to treat multiple myeloma (MM). We generated a retroviral…”
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Neuron-specific enolase-cre mouse line with cre activity in specific neuronal populations by Kwon, Chang-Hyuk, Zhou, Jing, Li, Yanjiao, Kim, Ki Woo, Hensley, Lori L., Baker, Suzanne J., Parada, Luis F.

“…To establish genetic tools for conditional gene deletion in mouse neurons, we generated two independent neuron‐specific enolase (Nse)‐cre transgenic lines. The…”
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