Search Results - "Kwon, Brian K."

Development of a NanoLC-MS workflow for high-sensitivity global lipidomic analysis by Zardini Buzatto, Adriana, Kwon, Brian K., Li, Liang

“…Lipidomics focuses on the comprehensive analysis of lipids and their interactions with other molecules. Many biological samples are available in small volumes…”
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Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation by Ashok, Anushruti, Andrabi, Syed Suhail, Mansoor, Saffar, Kuang, Youzhi, Kwon, Brian K, Labhasetwar, Vinod

“…Free radicals are formed as a part of normal metabolic activities but are neutralized by the endogenous antioxidants present in cells/tissue, thus maintaining…”
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Quantifying Intraparenchymal Hemorrhage after Traumatic Spinal Cord Injury: A Review of Methodology by Malomo, Toluyemi, Allard Brown, Aysha, Bale, Kirsten, Yung, Andrew, Kozlowski, Piotr, Heran, Manraj, Streijger, Femke, Kwon, Brian K

“…Intraparenchymal hemorrhage (IPH) after a traumatic injury has been associated with poor neurological outcomes. Although IPH may result from the initial…”
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Risk factors for cage migration and cage retropulsion following transforaminal lumbar interbody fusion by Park, Man-Kyu, Kim, Kyoung-Tae, Bang, Woo-Seok, Cho, Dae-Chul, Sung, Joo-Kyung, Lee, Young-Seok, Lee, Chang Kyu, Kim, Chi Heon, Kwon, Brian K., Lee, Won-Kee, Han, Inbo

“…Transforaminal lumbar interbody fusion (TLIF) is a widely accepted surgical procedure, but cage migration (CM) and cage retropulsion (CR) are associated with…”
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A Clinical Practice Guideline for the Management of Acute Spinal Cord Injury: Introduction, Rationale, and Scope by Fehlings, Michael G., Tetreault, Lindsay A., Wilson, Jefferson R., Kwon, Brian K., Burns, Anthony S., Martin, Allan R., Hawryluk, Gregory, Harrop, James S.

“…Acute spinal cord injury (SCI) is a traumatic event that results in disturbances to normal sensory, motor, or autonomic function and ultimately affects a…”
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A systematic review of cellular transplantation therapies for spinal cord injury by Tetzlaff, Wolfram, Okon, Elena B, Karimi-Abdolrezaee, Soheila, Hill, Caitlin E, Sparling, Joseph S, Plemel, Jason R, Plunet, Ward T, Tsai, Eve C, Baptiste, Darryl, Smithson, Laura J, Kawaja, Michael D, Fehlings, Michael G, Kwon, Brian K

“…Cell transplantation therapies have become a major focus in pre-clinical research as a promising strategy for the treatment of spinal cord injury (SCI). In…”
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Hemodynamic Management of Acute Spinal Cord Injury: A Literature Review by Lee, Young-Seok, Kim, Kyoung-Tae, Kwon, Brian K.

“…The goal of acute spinal cord injury (SCI) management is to reduce secondary injuries and improve neurological recovery after its occurrence. This review aimed…”
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Predicting Injury Severity and Neurological Recovery after Acute Cervical Spinal Cord Injury: A Comparison of Cerebrospinal Fluid and Magnetic Resonance Imaging Biomarkers by Dalkilic, Turker, Fallah, Nader, Noonan, Vanessa K, Salimi Elizei, Sanam, Dong, Kevin, Belanger, Lise, Ritchie, Leanna, Tsang, Angela, Bourassa-Moreau, Etienne, Heran, Manraj K S, Paquette, Scott J, Ailon, Tamir, Dea, Nicolas, Street, John, Fisher, Charles G, Dvorak, Marcel F, Kwon, Brian K

“…Biomarkers of acute human spinal cord injury (SCI) could provide a more objective measure of spinal cord damage and a better predictor of neurological outcome…”
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A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury by Fehlings, Michael G, Theodore, Nicholas, Harrop, James, Maurais, Gilles, Kuntz, Charles, Shaffrey, Chris I, Kwon, Brian K, Chapman, Jens, Yee, Albert, Tighe, Allyson, McKerracher, Lisa

“…Multiple lines of evidence have validated the Rho pathway as important in controlling the neuronal response to growth inhibitory proteins after central nervous…”
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A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury by Kwon, Brian K, Okon, Elena, Hillyer, Jessica, Mann, Cody, Baptiste, Darryl, Weaver, Lynne C, Fehlings, Michael G, Tetzlaff, Wolfram

“…An increasing number of therapies for spinal cord injury (SCI) are emerging from the laboratory and seeking translation into human clinical trials. Many of…”
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Economic evaluation comparing intraoperative cone beam CT-based navigation and conventional fluoroscopy for the placement of spinal pedicle screws: a patient-level data cost-effectiveness analysis by Dea, Nicolas, MD, MSc, Fisher, Charles G., MD, MHSc, Batke, Juliet, BSc, Strelzow, Jason, MD, Mendelsohn, Daniel, MD, Paquette, Scott J., MD, Kwon, Brian K., MD, PhD, Boyd, Michael D., MD, Dvorak, Marcel F.S., MD, Street, John T., MD, PhD

“…Abstract Background Context Pedicle screws are routinely used in contemporary spinal surgery. Screw misplacement may be asymptomatic but is also correlated…”
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The influence of time from injury to surgery on motor recovery and length of hospital stay in acute traumatic spinal cord injury: an observational Canadian cohort study by Dvorak, Marcel F, Noonan, Vanessa K, Fallah, Nader, Fisher, Charles G, Finkelstein, Joel, Kwon, Brian K, Rivers, Carly S, Ahn, Henry, Paquet, Jérôme, Tsai, Eve C, Townson, Andrea, Attabib, Najmedden, Bailey, Christopher S, Christie, Sean D, Drew, Brian, Fourney, Daryl R, Fox, Richard, Hurlbert, R John, Johnson, Michael G, Linassi, A G, Parent, Stefan, Fehlings, Michael G

“…To determine the influence of time from injury to surgery on neurological recovery and length of stay (LOS) in an observational cohort of individuals with…”
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Prophylactic postoperative measures to minimize surgical site infections in spine surgery: systematic review and evidence summary by Tan, Terence, Lee, Hui, Huang, Milly S., Rutges, Joost, Marion, Travis E., Mathew, Joseph, Fitzgerald, Mark, Gonzalvo, Augusto, Hunn, Martin K., Kwon, Brian K., Dvorak, Marcel F., Tee, Jin

“…There are three phases in prophylaxis of surgical site infections (SSI): preoperative, intraoperative and postoperative. There is lack of consensus and paucity…”
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A Direct Comparison between Norepinephrine and Phenylephrine for Augmenting Spinal Cord Perfusion in a Porcine Model of Spinal Cord Injury by Streijger, Femke, So, Kitty, Manouchehri, Neda, Gheorghe, Ana, Okon, Elena B, Chan, Ryan M, Ng, Benjamin, Shortt, Katelyn, Sekhon, Mypinder S, Griesdale, Donald E, Kwon, Brian K

“…Current clinical guidelines recommend elevating the mean arterial blood pressure (MAP) to increase spinal cord perfusion in patients with acute spinal cord…”
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Cardio-centric hemodynamic management improves spinal cord oxygenation and mitigates hemorrhage in acute spinal cord injury by Williams, Alexandra M., Manouchehri, Neda, Erskine, Erin, Tauh, Keerit, So, Kitty, Shortt, Katelyn, Webster, Megan, Fisk, Shera, Billingsley, Avril, Munro, Alex, Tigchelaar, Seth, Streijger, Femke, Kim, Kyoung-Tae, Kwon, Brian K., West, Christopher R.

“…Chronic high-thoracic and cervical spinal cord injury (SCI) results in a complex phenotype of cardiovascular consequences, including impaired left ventricular…”
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Characterization of the gut microbiome in a porcine model of thoracic spinal cord injury by Doelman, Adam, Tigchelaar, Seth, McConeghy, Brian, Sinha, Sunita, Keung, Martin S, Manouchehri, Neda, Webster, Megan, Fisk, Shera, Morrison, Charlotte, Streijger, Femke, Nislow, Corey, Kwon, Brian K

“…The gut microbiome is a diverse network of bacteria which inhabit our digestive tract and is crucial for efficient cellular metabolism, nutrient absorption,…”
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Emerging repair, regeneration, and translational research advances for spinal cord injury by Kwon, Brian K, Sekhon, Lali H, Fehlings, Michael G

“…Literature review of basic scientific and clinical research in spinal cord injury (SCI). To provide physicians with an overview of the neurobiologic challenges…”
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The Epidemiology of Traumatic Spinal Cord Injury in British Columbia, Canada by LENEHAN, Brian, STREET, John, KWON, Brian K, NOONAN, Vanessa, HONGBIN ZHANG, FISHER, Charles G, DVORAK, Marcel F

“…Retrospective observational study utilizing prospectively collected population-based data. To describe the epidemiology and demographics of all patients with…”
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Morbidity and mortality of major adult spinal surgery. A prospective cohort analysis of 942 consecutive patients by Street, John T., MD, PhD, Lenehan, Brian J., MD, DiPaola, Christian P., MD, Boyd, Michael D., MD, Kwon, Brian K., MD, PhD, Paquette, Scott J., MD, Dvorak, Marcel F.S., MD, Rampersaud, Y. Raja, MD, Fisher, Charles G., MD

“…Abstract Background context To date, most reports on the incidence of adverse events (AEs) in spine surgery have been retrospective and dependent on data…”
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Development of a machine learning algorithm for predicting in-hospital and 1-year mortality after traumatic spinal cord injury by Fallah, Nader, Noonan, Vanessa K., Waheed, Zeina, Rivers, Carly S., Plashkes, Tova, Bedi, Manekta, Etminan, Mahyar, Thorogood, Nancy P., Ailon, Tamir, Chan, Elaine, Dea, Nicolas, Fisher, Charles, Charest-Morin, Raphaele, Paquette, Scott, Park, SoEyun, Street, John T., Kwon, Brian K., Dvorak, Marcel F.

“…Current prognostic tools such as the Injury Severity Score (ISS) that predict mortality following trauma do not adequately consider the unique characteristics…”
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