Search Results - "Kwok Chong Chow, Billy"
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Unlocking the Non-IgE-Mediated Pseudo-Allergic Reaction Puzzle with Mas-Related G-Protein Coupled Receptor Member X2 (MRGPRX2)
Published in Cells (Basel, Switzerland) (27-04-2021)“…Mas-related G-protein coupled receptor member X2 (MRGPRX2) is a class A GPCR expressed on mast cells. Mast cells are granulated tissue-resident cells known for…”
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Protective Effect of Genistein against Compound 48/80 Induced Anaphylactoid Shock via Inhibiting MAS Related G Protein-Coupled Receptor X2 (MRGPRX2)
Published in Molecules (Basel, Switzerland) (25-02-2020)“…Anaphylactoid shock is a fatal hypersensitivity response caused by non-IgE mediated mast cell activation. These reactions are mediated by a family of G…”
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3
IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion
Published in Nature communications (28-04-2021)“…COP1 and COP9 signalosome (CSN) are the substrate receptor and deneddylase of CRL4 E3 ligase, respectively. How they functionally interact remains unclear…”
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Central and Peripheral Administration of Secretin Inhibits Food Intake in Mice through the Activation of the Melanocortin System
Published in Neuropsychopharmacology (New York, N.Y.) (01-01-2011)“…Secretin (Sct) is released into the circulation postprandially from the duodenal S-cells. The major functions of Sct originated from the gastrointestinal…”
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The cerebellar-hypothalamic circuits: Potential pathways underlying cerebellar involvement in somatic-visceral integration
Published in Brain Research Reviews (30-08-2006)“…The cerebellum has been considered only as a classical subcortical center for motor control. However, accumulating experimental and clinical evidences have…”
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Effects of secretin gene knockout on the diversity, composition, and function of gut microbiota in adult male mice
Published in Frontiers in cellular and infection microbiology (13-12-2023)“…The gut microbiota plays a vital role in maintaining gastrointestinal homeostasis, however, whether it is influenced by gut hormones remains unknown. Secretin…”
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Secretin-dependent signals in the ventromedial hypothalamus regulate energy metabolism and bone homeostasis in mice
Published in Nature communications (03-02-2024)“…Secretin, though originally discovered as a gut-derived hormone, is recently found to be abundantly expressed in the ventromedial hypothalamus, from which the…”
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The Knockout of Secretin in Cerebellar Purkinje Cells Impairs Mouse Motor Coordination and Motor Learning
Published in Neuropsychopharmacology (New York, N.Y.) (01-05-2014)“…Secretin (SCT) was first considered to be a gut hormone regulating gastrointestinal functions when discovered. Recently, however, central actions of SCT have…”
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SM17, a new IL‐17RB‐targeting antibody, ameliorates disease progression in a mouse model of atopic dermatitis
Published in Allergy (Copenhagen) (01-06-2024)Get full text
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10
Central Control of Feeding Behavior by the Secretin, PACAP, and Glucagon Family of Peptides
Published in Frontiers in endocrinology (Lausanne) (07-02-2017)“…Constituting a group of structurally related brain-gut peptides, secretin (SCT), pituitary adenylate cyclase-activating peptide (PACAP), and glucagon (GCG)…”
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Regulation of the Human Secretin Gene Is Controlled by the Combined Effects of CpG Methylation, Sp1/Sp3 Ratio, and the E-Box Element
Published in Molecular endocrinology (Baltimore, Md.) (01-07-2004)“…To unravel the mechanisms that regulate the human secretin gene expression, in this study, we have used secretin-expressing (HuTu-80 cells, human duodenal…”
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Excitatory effect of histamine on neuronal activity of rat globus pallidus by activation of H2 receptors in vitro
Published in Neuroscience research (01-11-2005)“…Previous studies have revealed distribution of histaminergic fibers and presence of histamine receptors in globus pallidus (GP). In this study, the brain slice…”
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13
CpG Methylation and Transcription Factors Sp1 and Sp3 Regulate the Expression of the Human Secretin Receptor Gene
Published in Molecular endocrinology (Baltimore, Md.) (01-02-2004)“…The human secretin receptor (hSR) is an important glycoprotein receptor for regulating the secretion of pancreatic bicarbonate, water, and electrolytes. In…”
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Corrigendum: Central Control of Feeding Behavior by the Secretin, PACAP, and Glucagon Family of Peptides
Published in Frontiers in endocrinology (Lausanne) (18-07-2018)“…[This corrects the article DOI: 10.3389/fendo.2017.00018.]…”
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15
Cloning and characterization of a PAC1 receptor hop-1 splice variant in goldfish ( Carassius auratus)
Published in General and comparative endocrinology (15-01-2006)“…In several vertebrates, it has been demonstrated that alternative splicing of PAC1 receptor (PAC1-R) transcripts can generate a number of functional receptor…”
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Functional Segregation of the Highly Conserved Basic Motifs within the Third Endoloop of the Human Secretin Receptor
Published in Endocrinology (Philadelphia) (01-09-2001)“…In this study, a mutagenesis-based strategy was employed to assess the roles of two highly conserved motifs (KLR and RLAR) within the third endoloop of the…”
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Retinoic acid activates human secretin gene expression by Sp proteins and Nuclear Factor I in neuronal SH‐SY5Y cells
Published in Journal of neurochemistry (01-04-2005)“…Secretin is a neuropeptide that is expressed in distinct central neurones. As there is no information on how the secretin gene is regulated in neuronal cells,…”
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Role of N-Linked Glycosylation on the Function and Expression of the Human Secretin Receptor
Published in Endocrinology (Philadelphia) (01-11-1999)“…Secretin is a 27-amino acid long peptide hormone that regulates pancreatic water, bicarbonate, enzymes, and potassium ion secretion. The human secretin…”
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19
Excitatory effect of histamine on neuronal activity of rat globus pallidus by activation of H 2 receptors in vitro
Published in Neuroscience research (01-11-2005)“…Previous studies have revealed distribution of histaminergic fibers and presence of histamine receptors in globus pallidus (GP). In this study, the brain slice…”
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20
Identification of a potential receptor for both peptide histidine isoleucine and peptide histidine valine
Published in Endocrinology (Philadelphia) (01-04-2002)“…Peptide histidine isoleucine (PHI), peptide histidine valine (PHV), and vasoactive intestinal polypeptide (VIP) are cosynthesized from the same precursor and…”
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