Search Results - "Kwok, Jessica CF"
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Selective rab11 transport and the intrinsic regenerative ability of CNS axons
Published in eLife (08-08-2017)“…Neurons lose intrinsic axon regenerative ability with maturation, but the mechanism remains unclear. Using an in-vitro laser axotomy model, we show a…”
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Chondroitin sulfates in the developing rat hindbrain confine commissural projections of vestibular nuclear neurons
Published in Neural development (03-02-2012)“…Establishing correct neuronal circuitry is crucial to proper function of the vertebrate nervous system. The abundance of chondroitin sulfate (CS) proteoglycans…”
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3
New Model of Ventral Spinal Cord Lesion Induced by Balloon Compression in Rats
Published in Biomedicines (05-11-2020)“…Despite the variety of experimental models of spinal cord injury (SCI) currently used, the model of the ventral compression cord injury, which is commonly seen…”
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Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity
Published in The Journal of neuroscience (09-11-2016)“…Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain neurons in the CNS during development and control plasticity in…”
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Role of extracellular factors in axon regeneration in the CNS: implications for therapy
Published in Regenerative medicine (01-11-2008)“…The glial scar that forms after an injury to the CNS contains molecules that are inhibitory to axon growth. Understanding of the mechanisms of inhibition has…”
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Glycosaminoglycans in extracellular matrix organisation: are concepts from soft matter physics key to understanding the formation of perineuronal nets?
Published in Current opinion in structural biology (01-06-2018)“…•Glycosaminoglycan physical properties contribute to distinct biochemical functions.•Hyaluronan is a unique scaffolding material, enabling matrix…”
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The potential of memory enhancement through modulation of perineuronal nets
Published in British journal of pharmacology (01-09-2019)“…With an increasingly aging global population, the incidence of neurological diseases such as dementia is set to increase to unmanageable levels, yet there are…”
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Animals lacking link protein have attenuated perineuronal nets and persistent plasticity
Published in Brain (London, England : 1878) (01-08-2010)“…Chondroitin sulphate proteoglycans in the extracellular matrix restrict plasticity in the adult central nervous system and their digestion with chondroitinase…”
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In vitro modeling of perineuronal nets: hyaluronan synthase and link protein are necessary for their formation and integrity
Published in Journal of neurochemistry (01-09-2010)“…J. Neurochem. (2010) 114, 1447-1459. We have previously shown that all perineuronal nets (PNNs) bearing neurons express a hyaluronan synthase (HAS), a link…”
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10
MiR‐29 coordinates age‐dependent plasticity brakes in the adult visual cortex
Published in EMBO reports (05-11-2020)“…Visual cortical circuits show profound plasticity during early life and are later stabilized by molecular “brakes” limiting excessive rewiring beyond a…”
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Erratum To: MiR-29 coordinates age-dependent plasticity brakes in the adult visual cortex
Published in EMBO reports (07-01-2021)“…Graphical Abstract…”
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The chemorepulsive axon guidance protein semaphorin3A is a constituent of perineuronal nets in the adult rodent brain
Published in Molecular and cellular neuroscience (01-09-2013)“…In the adult rodent brain, subsets of neurons are surrounded by densely organised extracellular matrix called perineuronal nets (PNNs). PNNs consist of…”
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MiR‐29 coordinates age‐dependent plasticity brakes in the adult visual cortex
Published in EMBO reports (07-01-2021)Get full text
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14
Distribution and synthesis of extracellular matrix proteoglycans, hyaluronan, link proteins and tenascin-R in the rat spinal cord
Published in The European journal of neuroscience (01-03-2008)“…Perineuronal nets (PNNs) are dense extracellular matrix (ECM) structures that form around many neuronal cell bodies and dendrites late in development. They…”
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Effects of digesting chondroitin sulfate proteoglycans on plasticity in cat primary visual cortex
Published in The Journal of neuroscience (02-01-2013)“…Monocular deprivation (MD) during a critical period of postnatal development produces significant changes in the anatomy and physiology of the visual cortex,…”
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Proteoglycans in the central nervous system: plasticity, regeneration and their stimulation with chondroitinase ABC
Published in Restorative neurology and neuroscience (2008)“…After injury to the mammalian central nervous system (CNS), neurons are not able to regenerate their axons and recovery is limited by restricted plasticity…”
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Full length talin stimulates integrin activation and axon regeneration
Published in Molecular and cellular neuroscience (01-09-2015)“…Integrin function is regulated by activation involving conformational changes that modulate ligand-binding affinity and downstream signaling. Activation is…”
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