Search Results - "Kwok, C.F."
-
1
The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system
Published in Biomaterials (01-04-2014)“…Abstract Devices implanted into the body become encapsulated due to a foreign body reaction. In the central nervous system (CNS), this can lead to loss of…”
Get full text
Journal Article -
2
Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity
Published in The Journal of neuroscience (09-11-2016)“…Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain neurons in the CNS during development and control plasticity in…”
Get full text
Journal Article -
3
Extracellular matrix and perineuronal nets in CNS repair
Published in Developmental neurobiology (Hoboken, N.J.) (01-11-2011)“…A perineuronal net (PNN) is a layer of lattice‐like matrix which enwraps the surface of the soma and dendrites, and in some cases the axon initial segments, in…”
Get full text
Journal Article -
4
Oral treatment of 4-methylumbelliferone reduced perineuronal nets and improved recognition memory in mice
Published in Brain research bulletin (01-04-2022)“…Hyaluronan (HA) is a core constituent of perineuronal nets (PNNs) that surround subpopulations of neurones. The PNNs control synaptic stabilization in both the…”
Get full text
Journal Article -
5
Antibody recognizing 4-sulfated chondroitin sulfate proteoglycans restores memory in tauopathy-induced neurodegeneration
Published in Neurobiology of aging (01-11-2017)“…Chondroitin sulfate proteoglycans (CSPGs) are the main active component of perineuronal nets (PNNs). Digestion of the glycosaminoglycan chains of CSPGs with…”
Get full text
Journal Article -
6
The chemorepulsive axon guidance protein semaphorin3A is a constituent of perineuronal nets in the adult rodent brain
Published in Molecular and cellular neuroscience (01-09-2013)“…In the adult rodent brain, subsets of neurons are surrounded by densely organised extracellular matrix called perineuronal nets (PNNs). PNNs consist of…”
Get full text
Journal Article -
7
Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction
Published in Developmental cell (09-10-2017)“…Heparan sulfate proteoglycans (HSPGs) critically modulate adhesion-, growth-, and migration-related processes. Here, we show that the transmembrane protein,…”
Get full text
Journal Article -
8
Effects of digesting chondroitin sulfate proteoglycans on plasticity in cat primary visual cortex
Published in The Journal of neuroscience (02-01-2013)“…Monocular deprivation (MD) during a critical period of postnatal development produces significant changes in the anatomy and physiology of the visual cortex,…”
Get full text
Journal Article -
9
Full length talin stimulates integrin activation and axon regeneration
Published in Molecular and cellular neuroscience (01-09-2015)“…Integrin function is regulated by activation involving conformational changes that modulate ligand-binding affinity and downstream signaling. Activation is…”
Get full text
Journal Article -
10
Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing
Published in Molecular psychiatry (01-10-2021)“…Perineuronal nets (PNNs) are chondroitin sulphate proteoglycan-containing structures on the neuronal surface that have been implicated in the control of…”
Get full text
Journal Article -
11
Visualization of Perineuronal Nets in Central Nervous System Tissue Sections
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2020)“…The perineuronal net (PNN) is a specialized extracellular matrix structure that surrounds subpopulations of neurons in the central nervous system (CNS). The…”
Get more information
Journal Article -
12
In vitro modeling of perineuronal nets: hyaluronan synthase and link protein are necessary for their formation and integrity
Published in Journal of neurochemistry (01-09-2010)“…J. Neurochem. (2010) 114, 1447-1459. We have previously shown that all perineuronal nets (PNNs) bearing neurons express a hyaluronan synthase (HAS), a link…”
Get full text
Journal Article -
13
Secretion of a mammalian chondroitinase ABC aids glial integration at PNS/CNS boundaries
Published in Scientific reports (09-07-2020)“…Schwann cell grafts support axonal growth following spinal cord injury, but a boundary forms between the implanted cells and host astrocytes. Axons are…”
Get full text
Journal Article -
14
Chondroitinase ABC has a long-lasting effect on chondroitin sulphate glycosaminoglycan content in the injured rat brain
Published in Journal of neurochemistry (2008)“…Chondroitin sulphate proteoglycans (CSPGs) are axon growth inhibitory molecules present in the glial scar that play a part in regeneration failure after damage…”
Get full text
Journal Article -
15
Perineuronal Nets and CNS Plasticity and Repair
Published in Neural plasticity (01-01-2016)“…In the article “Development and Structural Variety of the Chondroitin Sulfate Proteoglycans-Contained Extracellular Matrix in the Mouse Brain,” N…”
Get full text
Journal Article -
16
Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation
Published in Neural plasticity (2019)“…The perineuronal net (PNN) is a mesh-like proteoglycan structure on the neuronal surface which is involved in regulating plasticity. The PNN regulates…”
Get full text
Journal Article -
17
The extracellular matrix and perineuronal nets in memory
Published in Molecular psychiatry (01-08-2022)“…All components of the CNS are surrounded by a diffuse extracellular matrix (ECM) containing chondroitin sulphate proteoglycans (CSPGs), heparan sulphate…”
Get full text
Journal Article -
18
Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory
Published in Aging (Albany, NY.) (28-06-2017)“…Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory…”
Get full text
Journal Article -
19
“GAG-ing with the neuron”: The role of glycosaminoglycan patterning in the central nervous system
Published in Experimental neurology (01-12-2015)“…Proteoglycans (PGs) are a diverse family of proteins that consist of one or more glycosaminoglycan (GAG) chains, covalently linked to a core protein. PGs are…”
Get full text
Journal Article -
20
Post Translational Modulation of β-Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis
Published in Neurochemical research (01-06-2019)“…Cell surface β-Amyloid precursor protein (APP) is known to have a functional role in iron homeostasis through stabilising the iron export protein ferroportin…”
Get full text
Journal Article