Plasma levels of the chemokine RANTES in macaque monkeys infected with pathogenic and non-pathogenic SIV/HIV-1 chimeric viruses at an early stage of infection

Plasma levels of the chemokine RANTES were examined in monkeys infected with either a pathogenic simian and human immunodeficiency chimeric virus (SHIV) or a non-pathogenic SHIV to determine whether RANTES levels were related to the pathogenicity of the virus, the plasma viral load, or the kinetics...

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Bibliographic Details
Published in:	Journal of Veterinary Medical Science Vol. 62; no. 12; pp. 1311 - 1312
Main Authors:	Kwofie, T.B. (Kyoto Univ. (Japan). Inst. for Virus Research), Haga, T, Iida, T, Hayami, M, Miura, T
Format:	Journal Article
Language:	English
Published:	Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01-12-2000 Japan Science and Technology Agency
Subjects:	AIDS Animals CD4 Lymphocyte Count CD8-Positive T-Lymphocytes Chemokine CCL5 - blood CHIMAERA Chimera Enzyme-Linked Immunosorbent Assay - veterinary HIV - immunology HIV - pathogenicity HIV Infections - immunology HIV Infections - virology Human immunodeficiency virus 1 Humans IMMUNODEFICIENCY Kinetics Macaca Monkey Diseases - immunology Monkey Diseases - virology MONKEYS RANTES SHIV Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - virology Simian immunodeficiency virus Simian Immunodeficiency Virus - immunology Simian Immunodeficiency Virus - pathogenicity VIRUSES
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Summary:	Plasma levels of the chemokine RANTES were examined in monkeys infected with either a pathogenic simian and human immunodeficiency chimeric virus (SHIV) or a non-pathogenic SHIV to determine whether RANTES levels were related to the pathogenicity of the virus, the plasma viral load, or the kinetics of CD4+ T-cells. In the results no significant correlation was found between the RANTES kinetics and changes in the CD4+ T-cell numbers nor the plasma viral loads in any of the monkeys, although a transient decrease of the RANTES level was observed in the pathogenic virus-infected monkeys. At least, the plasma RANTES level can not be used as an index of the pathogenicity of the virus at the early stage of infection.
Bibliography:	L70 2001003563 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0916-7250 1347-7439
DOI:	10.1292/jvms.62.1311