Search Results - "Kwekkeboom, Joanneke"

Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid by Brouwers, Hilde, Jónasdóttir, Hulda S, Kuipers, Marije E, Kwekkeboom, Joanneke C, Auger, Jennifer L, Gonzalez-Torres, Mayra, López-Vicario, Cristina, Clària, Joan, Freysdottir, Jona, Hardardottir, Ingibjorg, Garrido-Mesa, José, Norling, Lucy V, Perretti, Mauro, Huizinga, Tom W J, Kloppenburg, Margreet, Toes, René E M, Binstadt, Bryce, Giera, Martin, Ioan-Facsinay, Andreea

“…Polyunsaturated fatty acids (PUFAs) and their metabolites are potent regulators of inflammation. Generally, omega ( )-3 PUFAs are considered proresolving…”
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Inflammatory Cells in Patients with Endstage Knee Osteoarthritis: A Comparison between the Synovium and the Infrapatellar Fat Pad by Klein-Wieringa, Inge R, de Lange-Brokaar, Badelog J E, Yusuf, Erlangga, Andersen, Stefan N, Kwekkeboom, Joanneke C, Kroon, Herman M, van Osch, Gerjo J V M, Zuurmond, Anne-Marie, Stojanovic-Susulic, Vedrana, Nelissen, Rob G H H, Toes, René E M, Kloppenburg, Margreet, Ioan-Facsinay, Andreea

“…To get a better understanding of inflammatory pathways active in the osteoarthritic (OA) joint, we characterized and compared inflammatory cells in the…”
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Comparative Photoaffinity Profiling of Omega‑3 Signaling Lipid Probes Reveals Prostaglandin Reductase 1 as a Metabolic Hub in Human Macrophages by Gagestein, Berend, von Hegedus, Johannes H., Kwekkeboom, Joanneke C., Heijink, Marieke, Blomberg, Niek, van der Wel, Tom, Florea, Bogdan I., van den Elst, Hans, Wals, Kim, Overkleeft, Herman S., Giera, Martin, Toes, René E. M., Ioan-Facsinay, Andreea, van der Stelt, Mario

“…The fish oil constituent docosahexaenoic acid (DHA, 22:6 n-3) is a signaling lipid with anti-inflammatory properties. The molecular mechanisms underlying the…”
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Oleic acid enhances proliferation and calcium mobilization of CD3/CD28 activated CD4+ T cells through incorporation into membrane lipids by Hegedus, Johannes Hendrick, Jong, Anja J., Hoekstra, Anna T., Spronsen, Eric, Zhu, Wahwah, Cabukusta, Birol, Kwekkeboom, Joanneke C., Heijink, Marieke, Bos, Erik, Berkers, Celia R., Giera, Martin A., Toes, Rene E. M., Ioan‐Facsinay, Andreea

“…Unsaturated fatty acids (UFA) are crucial for T‐cell effector functions, as they can affect the growth, differentiation, survival, and function of T cells…”
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Baseline serum adipokine levels predict radiographic progression in early rheumatoid arthritis by Klein‐Wieringa, Inge R., van der Linden, Michael P. M., Knevel, Rachel, Kwekkeboom, Joanneke C., van Beelen, Els, Huizinga, Tom W. J., van der Helm‐van Mil, Annette, Kloppenburg, Margreet, Toes, René E. M., Ioan‐Facsinay, Andreea

“…Objective Adipose tissue can secrete soluble mediators (adipokines) with potent immune regulatory functions. Some adipokines have been previously associated…”
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Autoreactive B cells in rheumatoid arthritis include mainly activated CXCR3+ memory B cells and plasmablasts by Reijm, Sanne, Kwekkeboom, Joanneke C., Blomberg, Nienke J., Suurmond, Jolien, van der Woude, Diane, Toes, René E.M., Scherer, Hans U.

“…Many autoimmune diseases (AIDs) are characterized by the persistence of autoreactive B cell responses, which have been directly implicated in disease…”
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Adipocyte‐derived lipids modulate CD4+ T‐cell function by Ioan‐Facsinay, Andreea, Kwekkeboom, Joanneke C., Westhoff, Sanne, Giera, Martin, Rombouts, Yoann, Harmelen, Vanessa, Huizinga, Tom W. J., Deelder, André, Kloppenburg, Margreet, Toes, René E. M.

“…Adipose tissue contains several immune cells whose number and phenotype vary depending on the adiposity. In the present study, we show that IFN‐γ+ CD4+ T cells…”
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Acetylated bacterial proteins as potent antigens inducing an anti-modified protein antibody response by Volkov, Mikhail, Kampstra, Arieke S B, van Schie, Karin A J, van Mourik, Anouk G, Kwekkeboom, Joanneke C, de Ru, Arnoud, van Veelen, Peter A, Huizinga, Tom W J, Toes, René E M, van der Woude, Diane

“…ObjectiveGut-residing bacteria, such as Escherichia coli, can acetylate their proteome under conditions of amine starvation. It is postulated that the (gut)…”
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Oleic acid triggers metabolic rewiring of T cells poising them for T helper 9 differentiation by Reilly, Nathalie A., Sonnet, Friederike, Dekkers, Koen F., Kwekkeboom, Joanneke C., Sinke, Lucy, Hilt, Stan, Suleiman, Hayat M., Hoeksema, Marten A., Mei, Hailiang, van Zwet, Erik W., Everts, Bart, Ioan-Facsinay, Andreea, Jukema, J. Wouter, Heijmans, Bastiaan T.

“…T cells are the most common immune cells in atherosclerotic plaques, and the function of T cells can be altered by fatty acids. Here, we show that pre-exposure…”
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Adipocytes modulate the phenotype of human macrophages through secreted lipids by Klein-Wieringa, Inge R, Andersen, Stefan N, Kwekkeboom, Joanneke C, Giera, Martin, de Lange-Brokaar, Badelog J E, van Osch, Gerjo J V M, Zuurmond, Anne-Marie, Stojanovic-Susulic, Vedrana, Nelissen, Rob G H H, Pijl, Hanno, Huizinga, Tom W J, Kloppenburg, Margreet, Toes, René E' M, Ioan-Facsinay, Andreea

“…Previous studies have shown accumulation and an enhanced proinflammatory profile of macrophages in adipose tissue of obese mice, indicating the presence of an…”
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Functional and phenotypical analysis of IL‐6‐secreting CD4+ T cells in human adipose tissue by de Jong, Anja J., Pollastro, Sabrina, Kwekkeboom, Joanneke C., Andersen, Stefan N., Dorjée, Annemarie L., Bakker, Aleida M., Alzaid, Fawaz, Soprani, Antoine, Nelissen, Rob G.H.H., Mullers, Jan B., Venteclef, Nicolas, de Vries, Niek, Kloppenburg, Margreet, Toes, René E.M., Ioan‐Facsinay, Andreea

“…Emerging evidence indicates that a dynamic interplay between the immune system and adipocytes contributes to the disturbed homeostasis in adipose tissue of…”
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Are Baseline High Molecular Weight Adiponectin Levels Associated with Radiographic Progression in Rheumatoid Arthritis and Osteoarthritis? by KLEIN-WIERINGA, Inge R, ANDERSEN, Stefan N, HERB-VAN TOOM, Linda, KWEKKEBOOM, Joanneke C, VAN DER HELM-VAN MIL, Anette H. M, MEULENBELT, Ingrid, HUIZINGA, Tom W. J, KLOPPENBURG, Margreet, TOES, Rene E. M, IOAN-FACSINAY, Andreea

“…To investigate whether high molecular weight adiponectin (hmwAPN) mediates the associations of total adiponectin (totAPN) with radiographic progression in…”
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Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation by Kissel, Theresa, Ge, Changrong, Hafkenscheid, Lise, Kwekkeboom, Joanneke C, Slot, Linda M, Cavallari, Marco, He, Yibo, van Schie, Karin A, Vergroesen, Rochelle D, Kampstra, Arieke S B, Reijm, Sanne, Stoeken-Rijsbergen, Gerrie, Koeleman, Carolien, Voortman, Lennard M, Heitman, Laura H, Xu, Bingze, Pruijn, Ger J M, Wuhrer, Manfred, Rispens, Theo, Huizinga, Tom W J, Scherer, Hans Ulrich, Reth, Michael, Holmdahl, Rikard, Toes, Rene E M

“…The hallmark autoantibodies in rheumatoid arthritis are characterized by variable domain glycans (VDGs). Their abundant occurrence results from the selective…”
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Adipocytes from the infrapatellar fat pad of OA patients modulate CD4+ T cell cytokine production by Ioan-Facsinay, Andreea, Kwekkeboom, Joanneke C, Kloppenburg, Margreet, Toes, Rene EM

“…Meeting abstractsEMPTY Aim As shown in previous studies, the infrapatellar fat pad (IFP) of OA patients has an inflammatory phenotype and is infiltrated with…”
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Lack of high BMI-related features in adipocytes and inflammatory cells in the infrapatellar fat pad (IFP) by de Jong, Anja J, Klein-Wieringa, Inge R, Andersen, Stefan N, Kwekkeboom, Joanneke C, Herb-van Toorn, Linda, de Lange-Brokaar, Badelog J E, van Delft, Danny, Garcia, John, Wei, Wu, van der Heide, Huub J L, Bastiaansen-Jenniskens, Yvonne M, van Osch, Gerjo J V M, Zuurmond, Annemarie M, Stojanovic-Susulic, Vedrana, Nelissen, Rob G H H, Toes, René E M, Kloppenburg, Margreet, Ioan-Facsinay, Andreea

“…Obesity is associated with the development and progression of osteoarthritis (OA). Although the infrapatellar fat pad (IFP) could be involved in this…”
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Targeted lipidomics reveals activation of resolution pathways in knee osteoarthritis in humans by Jónasdóttir, Hulda S., MSc, Brouwers, Hilde, MSc, Kwekkeboom, Joanneke C., Ing, van der Linden, Enrike M.J., MD, PhD, Huizinga, Tom, MD, PhD, Kloppenburg, Margreet, MD, PhD, Toes, Rene E.M., PhD, Giera, Martin, PhD, Ioan-Facsinay, Andreea, PhD

“…Summary Objective To investigate the presence of inflammation and resolution pathways in osteoarthritis (OA). Design Tissues were obtained from knee OA…”
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Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis by Yusuf, Erlangga, Ioan-Facsinay, Andreea, Bijsterbosch, Jessica, Klein-Wieringa, Inge, Kwekkeboom, Joanneke, Slagboom, P Eline, Huizinga, Tom W J, Kloppenburg, Margreet

“…To investigate the association between baseline serum adipokines levels-leptin, adiponectin and resistin-and long-term progression of hand osteoarthritis…”
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Advanced LC–MS/MS Platform for the Analysis of Specialized Pro-Resolving Lipid Mediators by Jónasdóttir, Hulda S, Ioan-Facsinay, Andreea, Kwekkeboom, Joanneke, Brouwers, Hilde, Zuurmond, Anne-Marie, Toes, René, Deelder, André M, Giera, Martin

“…Here we present an advanced platform for the analysis of specialized pro-resolving mediators (SPM), including a set of pro-inflammatory lipids and respective…”
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Adipocyte-derived lipids modulate CD4 super(+) T-cell function by Ioan-Facsinay, Andreea, Kwekkeboom, Joanneke C, Westhoff, Sanne, Giera, Martin, Rombouts, Yoann, Harmelen, Vanessa, Huizinga, Tom WJ, Deelder, Andre, Kloppenburg, Margreet, Toes, Rene EM

“…Adipose tissue contains several immune cells whose number and phenotype vary depending on the adiposity. In the present study, we show that IFN-[gamma]…”
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