Search Results - "Kwek, Serena S"

Single-cell RNA-seq reveals cell type-specific molecular and genetic associations to lupus by Perez, Richard K, Gordon, M Grace, Subramaniam, Meena, Kim, Min Cheol, Hartoularos, George C, Targ, Sasha, Sun, Yang, Ogorodnikov, Anton, Bueno, Raymund, Lu, Andrew, Thompson, Mike, Rappoport, Nadav, Dahl, Andrew, Lanata, Cristina M, Matloubian, Mehrdad, Maliskova, Lenka, Kwek, Serena S, Li, Tony, Slyper, Michal, Waldman, Julia, Dionne, Danielle, Rozenblatt-Rosen, Orit, Fong, Lawrence, Dall'Era, Maria, Balliu, Brunilda, Regev, Aviv, Yazdany, Jinoos, Criswell, Lindsey A, Zaitlen, Noah, Ye, Chun Jimmie

“…Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Knowledge of circulating immune cell types and states associated with SLE remains…”
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Immune Toxicities Elicted by CTLA-4 Blockade in Cancer Patients Are Associated with Early Diversification of the T-cell Repertoire by Oh, David Y, Cham, Jason, Zhang, Li, Fong, Grant, Kwek, Serena S, Klinger, Mark, Faham, Malek, Fong, Lawrence

“…While immune checkpoint blockade elicits efficacious responses in many patients with cancer, it also produces a diverse and unpredictable number of…”
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GM-CSF and ipilimumab therapy in metastatic melanoma: Clinical outcomes and immunologic responses by Kwek, Serena S., Kahn, James, Greaney, Samantha K., Lewis, Jera, Cha, Edward, Zhang, Li, Weber, Robert W., Leonard, Lonnie, Markovic, Svetomir N., Fong, Lawrence, Spitler, Lynn E.

“…We conducted a phase II clinical trial of anti-CTLA-4 antibody (ipilimumab) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in 22 patients with…”
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Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer by Oh, David Y., Kwek, Serena S., Raju, Siddharth S., Li, Tony, McCarthy, Elizabeth, Chow, Eric, Aran, Dvir, Ilano, Arielle, Pai, Chien-Chun Steven, Rancan, Chiara, Allaire, Kathryn, Burra, Arun, Sun, Yang, Spitzer, Matthew H., Mangul, Serghei, Porten, Sima, Meng, Maxwell V., Friedlander, Terence W., Ye, Chun Jimmie, Fong, Lawrence

“…Responses to anti-PD-1 immunotherapy occur but are infrequent in bladder cancer. The specific T cells that mediate tumor rejection are unknown. T cells from…”
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Systemic Immunity Is Required for Effective Cancer Immunotherapy by Spitzer, Matthew H., Carmi, Yaron, Reticker-Flynn, Nathan E., Kwek, Serena S., Madhireddy, Deepthi, Martins, Maria M., Gherardini, Pier Federico, Prestwood, Tyler R., Chabon, Jonathan, Bendall, Sean C., Fong, Lawrence, Nolan, Garry P., Engleman, Edgar G.

“…Immune responses involve coordination across cell types and tissues. However, studies in cancer immunotherapy have focused heavily on local immune responses in…”
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Unmasking the immune recognition of prostate cancer with CTLA4 blockade by Kwek, Serena S., Cha, Edward, Fong, Lawrence

“…Cytotoxic T lymphocyte-associated antigen 4 (CTLA4) represents a crucial immune checkpoint, the blockade of which can potentiate anti-tumour immunity. This…”
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Exhausted intratumoral Vδ2− γδ T cells in human kidney cancer retain effector function by Rancan, Chiara, Arias-Badia, Marcel, Dogra, Pranay, Chen, Brandon, Aran, Dvir, Yang, Hai, Luong, Diamond, Ilano, Arielle, Li, Jacky, Chang, Hewitt, Kwek, Serena S., Zhang, Li, Lanier, Lewis L., Meng, Maxwell V., Farber, Donna L., Fong, Lawrence

“…Gamma delta (γδ) T cells reside within human tissues including tumors, but their function in mediating antitumor responses to immune checkpoint inhibition is…”
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Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade by Pai, Chien-Chun Steven, Huang, John T., Lu, Xiaoqing, Simons, Donald M., Park, Chanhyuk, Chang, Anthony, Tamaki, Whitney, Liu, Eric, Roybal, Kole T., Seagal, Jane, Chen, Mingyi, Hagihara, Katsunobu, Wei, Xiao X., DuPage, Michel, Kwek, Serena S., Oh, David Y., Daud, Adil, Tsai, Katy K., Wu, Clint, Zhang, Li, Fasso, Marcella, Sachidanandam, Ravi, Jayaprakash, Anitha, Lin, Ingrid, Casbon, Amy-Jo, Kinsbury, Gillian A., Fong, Lawrence

“…Resistance to checkpoint-blockade treatments is a challenge in the clinic. We found that although treatment with combined anti-CTLA-4 and anti-PD-1 improved…”
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Diversity of antigen-specific responses induced in vivo with CTLA-4 blockade in prostate cancer patients by Kwek, Serena S, Dao, Vinh, Roy, Ritu, Hou, Yafei, Alajajian, David, Simko, Jeffrey P, Small, Eric J, Fong, Lawrence

“…CTLA-4 is a surface receptor on activated T cells that delivers an inhibitory signal, serving as an immune checkpoint. Treatment with anti-CTLA-4 Abs can…”
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Potentiating Endogenous Antitumor Immunity to Prostate Cancer through Combination Immunotherapy with CTLA4 Blockade and GM-CSF by FONG, Lawrence, KWEK, Serena S, SMALL, Eric J, O'BRIEN, Shaun, KAVANAGH, Brian, MCNEEL, Douglas G, WEINBERG, Vivian, LIN, Amy M, ROSENBERG, Jonathan, RYAN, Charles J, RINI, Brian I

“…CTL-associated antigen 4 (CTLA4) is a costimulatory molecule expressed on activated T cells that delivers an inhibitory signal to these T cells. CTLA4 blockade…”
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Tumor morphology and location associate with immune cell composition in pleomorphic sarcoma by Wustrack, Rosanna L., Shao, Evans, Sheridan, Joey, Zimel, Melissa, Cho, Soo-Jin, Horvai, Andrew E., Luong, Diamond, Kwek, Serena S., Fong, Lawrence, Okimoto, Ross A.

“…Background Soft-tissue sarcomas (STS) are a rare group of mesenchymal malignancies that account for approximately 1% of adult human cancer. Undifferentiated…”
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Functional analysis and intracellular localization of p53 modified by SUMO-1 by KWEK, Serena S. S, DERRY, Jason, TYNER, Angela L, ZHIYUAN SHEN, GUDKOV, Andrei V

“…p53 tumor suppressor is a subject of several post-translational modifications, including phosphorylation, ubiquitination and acetylation, which regulate p53…”
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Preexisting Levels of CD4 T Cells Expressing PD-1 Are Related to Overall Survival in Prostate Cancer Patients Treated with Ipilimumab by Kwek, Serena S, Lewis, Jera, Zhang, Li, Weinberg, Vivian, Greaney, Samantha K, Harzstark, Andrea L, Lin, Amy M, Ryan, Charles J, Small, Eric J, Fong, Lawrence

“…Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) blockade can induce tumor regression and improved survival in cancer patients. This treatment can enhance…”
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Apoptosis Inhibitor as a Suppressor of Tumor Progression: Expression of Bcl-2 Eliminates Selective Advantages for p53-Deficient Cells in the Tumor by Gurova, Katerina V., Kwek, Serena S. S., Koman, Igor E., Komarov, Andrei P., Kandel, Eugene, Nikiforov, Mikhail A., Gudkov, Andrei V.

“…Inactivation of p53 and expression of Bcl-2, frequently occurring during tumor progression, have different prognostic value: while inactivation of p53 is…”
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Abstract 4688: Single-cell discrimination of altered human T cell states in the bladder tumor microenvironment by Oh, David Yoonsuk, Kwek, Serena S., Mangul, Serghei, Raju, Siddharth S., Targ, Sasha, Burra, Arun, Chow, Eric, Aran, Dvir, Porten, Sima, Meng, Maxwell V., Friedlander, Terence W., Ye, Chun Jimmie, Fong, Lawrence

“…Abstract Bladder cancer can be responsive to immunotherapies such as anti-PD-1 and anti-PD-L1 checkpoint inhibitors, but overall response rates are low…”
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Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis by Kwek, S S, Roy, R, Zhou, H, Climent, J, Martinez-Climent, J A, Fridlyand, J, Albertson, D G

“…Co-amplification at chromosomes 8p11–8p12 and 11q12–11q14 occurs often in breast tumors, suggesting possible cooperation between genes in these regions in…”
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Suppression of apoptosis by bcl-2 does not prevent p53-mediated control of experimental metastasis and anchorage dependence by NIKIFOROV, M. A, KWEK, S. S. S, MEHTA, R, ARTWOHL, J. E, LOWE, S. W, TAPAS DAS GUPTA, DEICHMAN, G. I, GUDKOV, A. V

“…Mutations in the p53 tumor suppressor gene are frequently associated with the metastatic stage of tumor progression. Inactivation of p53 was shown to promote…”
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Structure and Regulation of the Mouse ing1 Gene by Zeremski, Marija, Hill, Jason E., Kwek, Serena S.S., Grigorian, Irina A., Gurova, Katerina V., Garkavtsev, Igor V., Diatchenko, Luda, Koonin, Eugene V., Gudkov, Andrei V.

“…The human ING1 gene encodes nuclear protein p33ING1, previously shown to cooperate with p53 in cell growth control (Garkavtsev, I., Grigorian, I. A.,…”
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