Search Results - "Kwek, P."
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Modulatory Effects of Sex Steroid Hormones on Brain-Derived Neurotrophic Factor-Tyrosine Kinase B Expression during Adolescent Development in C57Bl/6 Mice
Published in Journal of neuroendocrinology (01-05-2012)“…Sex steroid hormones and neurotrophic factors are involved in pruning and shaping the adolescent brain and have been implicated in the pathogenesis of…”
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Fragment-based lead discovery of indazole-based compounds as AXL kinase inhibitors
Published in Bioorganic & medicinal chemistry (01-11-2021)“…[Display omitted] AXL is a member of the TAM (TYRO3, AXL, MER) subfamily of receptor tyrosine kinases. It is upregulated in a variety of cancers and its…”
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Correction to “Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3”
Published in ACS medicinal chemistry letters (08-08-2019)“…[This corrects the article DOI: 10.1021/acsmedchemlett.9b00170.]…”
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Prevention of falls in a geriatric ward
Published in Annals of the Academy of Medicine, Singapore (01-05-1997)“…Falls occurring in the hospital are significant events because of the injuries sustained, extended hospital stay and potential medicolegal implications. We…”
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Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3
Published in ACS medicinal chemistry letters (13-06-2019)“…SMYD3 is a histone methyltransferase that regulates gene transcription, and its overexpression is associated with multiple human cancers. A novel class of…”
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Identification of covalent active site inhibitors of dengue virus protease
Published in Drug design, development and therapy (01-01-2015)“…Dengue virus (DENV) protease is an attractive target for drug development; however, no compounds have reached clinical development to date. In this study, we…”
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Strategies adopted and lessons learnt during the severe acute respiratory syndrome crisis in Singapore
Published in Reviews in medical virology (01-01-2005)“…In Singapore, the military was actively involved in the containment of the outbreak of severe acute respiratory syndrome (SARS) last year. The outbreak started…”
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