Search Results - "Kwapis, Janine"

A neuroscientist’s guide to transgenic mice and other genetic tools by Navabpour, Shaghayegh, Kwapis, Janine L., Jarome, Timothy J.

“…•Mouse knock-outs and knock-ins help identify the function of specific genes but often lack temporal and spatial control.•Tet-On and Tet-Off systems allow…”
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Molecular Mechanisms of Reconsolidation-Dependent Memory Updating by Bellfy, Lauren, Kwapis, Janine L

“…Memory is not a stable record of experience, but instead is an ongoing process that allows existing memories to be modified with new information through a…”
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Epigenetic mechanisms in fear conditioning: implications for treating post-traumatic stress disorder by Kwapis, Janine L, Wood, Marcelo A

“…Highlights • We review the role of epigenetics in fear consolidation, updating, and extinction. • For each memory phase, we document the epigenetic mechanisms…”
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Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala by Jarome, Timothy J, Werner, Craig T, Kwapis, Janine L, Helmstetter, Fred J

“…Protein degradation through the ubiquitin-proteasome system [UPS] plays a critical role in some forms of synaptic plasticity. However, its role in memory…”
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Long-lasting effects of disturbing the circadian rhythm or sleep in adolescence by Pifer, Gretchen C., Ferrara, Nicole C., Kwapis, Janine L.

“…Circadian rhythms are endogenous, near 24-hour rhythms that regulate a multitude of biological and behavioral processes across the diurnal cycle in most…”
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CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval by Jarome, Timothy J., Ferrara, Nicole C., Kwapis, Janine L., Helmstetter, Fred J.

“…•Memory retrieval increases proteasome activity and phosphorylation.•CaMKII regulates retrieval-induced proteasome activity in vivo and in vitro.•Activity…”
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Contributions of the rodent cingulate-retrosplenial cortical axis to associative learning and memory: A proposed circuit for persistent memory maintenance by Trask, Sydney, Ferrara, Nicole C., Jasnow, Aaron M., Kwapis, Janine L.

“…•The anterior cingulate and retrosplenial cortices are both involved in associative memory formation and recall.•The anterior cingulate cortex seems to be…”
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Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory by Kwapis, Janine L., Alaghband, Yasaman, Kramár, Enikö A., López, Alberto J., Vogel Ciernia, Annie, White, André O., Shu, Guanhua, Rhee, Diane, Michael, Christina M., Montellier, Emilie, Liu, Yu, Magnan, Christophe N., Chen, Siwei, Sassone-Corsi, Paolo, Baldi, Pierre, Matheos, Dina P., Wood, Marcelo A.

“…Aging is accompanied by impairments in both circadian rhythmicity and long-term memory. Although it is clear that memory performance is affected by circadian…”
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Time to learn: The role of the molecular circadian clock in learning and memory by Smies, Chad W., Bodinayake, Kasuni K., Kwapis, Janine L.

“…•Memory oscillates in a circadian manner.•Core circadian clock genes oscillate in memory-relevant brain regions.•Circadian rhythm genes interface with genes…”
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Connecting the Dots: Potential Interactions Between Sex Hormones and the Circadian System During Memory Consolidation by Boyd, Hannah M., Frick, Karyn M., Kwapis, Janine L.

“…Both the circadian clock and sex hormone signaling can strongly influence brain function, yet little is known about how these 2 powerful modulatory systems…”
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The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning by Kwapis, Janine L., Jarome, Timothy J., Lee, Jonathan L., Helmstetter, Fred J.

“…•Pre-training infusion of anisomycin into the RSC impairs trace and context fear conditioning.•Blocking NMDA receptors in the RSC also impairs retrieval of…”
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Special Issue "Molecular Mechanisms of Memory Formation and Modification" by Jarome, Timothy J, Kwapis, Janine L

“…Memory is vital to human functioning and controls future behavioral responses [...]…”
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HDAC3-Mediated Repression of the Nr4a Family Contributes to Age-Related Impairments in Long-Term Memory by Kwapis, Janine L, Alaghband, Yasaman, López, Alberto J, Long, Jeffrey M, Li, Xiang, Shu, Guanhua, Bodinayake, Kasuni K, Matheos, Dina P, Rapp, Peter R, Wood, Marcelo A

“…Aging is accompanied by cognitive deficits, including impairments in long-term memory formation. Understanding the molecular mechanisms that support preserved…”
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Does PKM(zeta) maintain memory? by Kwapis, Janine L, Helmstetter, Fred J

“…Highlights • We review the state of the literature on PKMζ and memory maintenance. • Research both for and against the idea that PKMζ maintains memory is…”
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Unconditioned perspectives: New vistas on learning from the Pavlovian society by Sharpe, Melissa J., Ferrara, Nicole C., Tronson, Natalie C., Perusini, Jennifer N., Kwapis, Janine L., Trask, Sydney

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Memory retrieval, reconsolidation, and extinction: Exploring the boundary conditions of post-conditioning cue exposure by Ferrara, Nicole C, Kwapis, Janine L, Trask, Sydney

“…Following fear conditioning, behavior can be reduced by giving many CS-alone presentations in a process known as extinction or by presenting a few CS-alone…”
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Trace and contextual fear conditioning are impaired following unilateral microinjection of muscimol in the ventral hippocampus or amygdala, but not the medial prefrontal cortex by Gilmartin, Marieke R., Kwapis, Janine L., Helmstetter, Fred J.

“…► Trace fear conditioning requires bilateral participation of the ventral hippocampus. ► The amygdala is necessary for both trace and delay fear learning. ►…”
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The clock gene Per1 may exert diurnal control over hippocampal memory consolidation by Bellfy, Lauren, Smies, Chad W, Bernhardt, Alicia R, Bodinayake, Kasuni K, Sebastian, Aswathy, Stuart, Emily M, Wright, Destiny S, Lo, Chen-Yu, Murakami, Shoko, Boyd, Hannah M, von Abo, Megan J, Albert, Istvan, Kwapis, Janine L

“…The circadian system influences many different biological processes, including memory performance. While the suprachiasmatic nucleus (SCN) functions as the…”
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Contextual Information Drives the Reconsolidation-Dependent Updating of Retrieved Fear Memories by Jarome, Timothy J, Ferrara, Nicole C, Kwapis, Janine L, Helmstetter, Fred J

“…Stored memories enter a temporary state of vulnerability following retrieval known as 'reconsolidation', a process that can allow memories to be modified to…”
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The circadian clock gene Per1 modulates context fear memory formation within the retrosplenial cortex in a sex-specific manner by Urban, Mark W., Lo, Chenyu, Bodinayake, Kasuni K., Brunswick, Chad A., Murakami, Shoko, Heimann, Ashley C., Kwapis, Janine L.

“…•Learning-induced Per1 cycles rhythmically in the RSC, peaking during the day.•Context fear conditioning transiently induces Per1 expression in the anterior…”
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