Search Results - "Kwan, T. L."

A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes by Baud, Matthias G. J., Lin-Shiao, Enrique, Cardote, Teresa, Tallant, Cynthia, Pschibul, Annica, Chan, Kwok-Ho, Zengerle, Michael, Garcia, Jordi R., Kwan, Terence T.-L., Ferguson, Fleur M., Ciulli, Alessio

“…Small molecules are useful tools for probing the biological function and therapeutic potential of individual proteins, but achieving selectivity is challenging…”
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Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides by Wu, Yuteng, Kaur, Amandeep, Fowler, Elaine, Wiedmann, Mareike M, Young, Reginald, Galloway, Warren R. J. D, Olsen, Lasse, Sore, Hannah F, Chattopadhyay, Anasuya, Kwan, Terence T.-L, Xu, Wenshu, Walsh, Stephen J, de Andrade, Peterson, Janecek, Matej, Arumugam, Senthil, Itzhaki, Laura S, Lau, Yu Heng, Spring, David R

“…Stapled peptides have great potential as modulators of protein–protein interactions (PPIs). However, there is a vast landscape of chemical features that can be…”
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A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates by Walsh, Stephen J, Omarjee, Soleilmane, Galloway, Warren R J D, Kwan, Terence T-L, Sore, Hannah F, Parker, Jeremy S, Hyvönen, Marko, Carroll, Jason S, Spring, David R

“…Antibody-drug conjugates (ADCs) are a class of targeted therapeutics that utilize the specificity of antibodies to selectively deliver highly potent cytotoxins…”
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Six month radiological and physiological outcomes in severe acute respiratory syndrome (SARS) survivors by Ng, C K, Chan, J W M, Kwan, T L, To, T S, Chan, Y H, Ng, F Y Y, Mok, T Y W

“…Background: The long term physiological and radiological outcomes of SARS survivors and their possible determinants are uncertain. Methods: SARS survivors in a…”
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Population-Based Information on Emergency Colorectal Surgery and Evaluation on Effect of Operative Volume on Mortality by Kwan, T. L., Lai, F., Lam, C. M., Yuen, W. C., Wai, A., Siu, Y. C., Shung, E., Law, W. L.

“…Introduction Population-based information on emergency surgery for colorectal conditions was limited. The present study was designed to review comprehensively…”
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Evaluation of various POSSUM models for predicting mortality in patients undergoing elective oesophagectomy for carcinoma by Lai, F., Kwan, T. L., Yuen, W. C., Wai, A., Siu, Y. C., Shung, E.

“…Background: The aim of the study was to validate the use of the Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity…”
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Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst by Kwan, Terence T-L, Boutureira, Omar, Frye, Elizabeth C, Walsh, Stephen J, Gupta, Moni K, Wallace, Stephen, Wu, Yuteng, Zhang, Fengzhi, Sore, Hannah F, Galloway, Warren R J D, Chin, Jason W, Welch, Martin, Bernardes, Gonçalo J L, Spring, David R

“…Transition metal catalysis has emerged as a powerful strategy to expand synthetic flexibility of protein modification. Herein, we report a cationic Ru(ii)…”
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Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates by Walsh, Stephen J, Omarjee, Soleilmane, Galloway, Warren R. J. D, Kwan, Terence T.-L, Sore, Hannah F, Parker, Jeremy S, Hyvönen, Marko, Carroll, Jason S, Spring, David R

“…Correction for 'A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug…”
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Pulmonary artery sarcoma diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration by Chan, Johnny W M, Chu, Stephanie Y Y, Lam, Connie H K, O, W H, Cheung, O Y, Kwan, T L, Leung, Alex K C, Law, W L

“…Pulmonary artery sarcoma is a rare disease with poor prognosis that has not been reported in Hong Kong. Its clinical and radiological presentation frequently…”
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Bronchial artery embolisation can be equally safe and effective in the management of chronic recurrent haemoptysis by Lee, Samuel, Chan, Johnny W M, Chan, Susan C H, Chan, Y H, Kwan, T L, Chan, M K, Ng, C K, Lee, M P, Law, W L, Mok, Thomas Y W

“…To examine the efficacy and safety of bronchial artery embolisation in patients with acute major haemoptysis and those with chronic recurrent haemoptysis…”
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Hepatic schistosomiasis by Fung, H S, Siu, Jimmy C W, Fan, T W, Lai, K C, Kwan, T L

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Effects of subcortical cerebral infarction on cortical glucose metabolism and cognitive function by Kwan, L T, Reed, B R, Eberling, J L, Schuff, N, Tanabe, J, Norman, D, Weiner, M W, Jagust, W J

“…The mechanism of dementia in subcortical cerebral infarction is incompletely understood. To determine how cognitive function is related to cortical metabolism…”
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Screening for vestibular schwannoma by magnetic resonance imaging: analysis of 1821 patients by Kwan, T L, Tang, K W, Pak, K K T, Cheung, J Y L

“…To study the spectrum of diseases that can be detected by magnetic resonance imaging in patients suspected to have vestibular schwannoma (acoustic neuroma)…”
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Authors' reply: Evaluation of various POSSUM models for predicting mortality in patients undergoing elective oesophagectomy for carcinoma (Br J Surg2007; 94: 1172-1178) by Kwan, T. L.

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Attitudes towards mental illness: testing the contact hypothesis among Chinese student nurses in Hong Kong by Callaghan, Patrick, Shan, Cheung Siu, Yu, Lau Suk, Ching, Lo Wai, Kwan, Tsui Lai

“…This study investigated whether previous contact with mental illness affected the attitudes to mental illness (AMI) of general student nurses in Hong Kong —…”
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Re: If not appendicitis, then what else can it be? A retrospective review of 1492 appendectomies by Kwan, H T L

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The effect of a psychiatric secondment on Hong Kong chinese student nurses' attitudes to mental illness by Callaghan, P, Shan, C S, Ching, L W, Kwan, T L

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A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugatesDedicated to Professor Jack Baldwin on the occasion of his 80th birthday.Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc04645j by Walsh, Stephen J, Omarjee, Soleilmane, Galloway, Warren R. J. D, Kwan, Terence T.-L, Sore, Hannah F, Parker, Jeremy S, Hyvönen, Marko, Carroll, Jason S, Spring, David R

“…Antibody-drug conjugates (ADCs) are a class of targeted therapeutics that utilize the specificity of antibodies to selectively deliver highly potent cytotoxins…”
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A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates† †Dedicated to Professor Jack Baldwin on the occasion of his 80th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc04645j by Walsh, Stephen J., Omarjee, Soleilmane, Galloway, Warren R. J. D., Kwan, Terence T.-L., Sore, Hannah F., Parker, Jeremy S., Hyvönen, Marko, Carroll, Jason S., Spring, David R.

“…Divinylpyrimidine (DVP) linkers enable access to highly stable and functional antibody–drug conjugates. Antibody–drug conjugates (ADCs) are a class of targeted…”
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Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalystDedicated to Professor Stuart L. Schreiber on the occasion of his 60th birthday.Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05313k by Kwan, Terence T.-L, Boutureira, Omar, Frye, Elizabeth C, Walsh, Stephen J, Gupta, Moni K, Wallace, Stephen, Wu, Yuteng, Zhang, Fengzhi, Sore, Hannah F, Galloway, Warren R. J. D, Chin, Jason W, Welch, Martin, Bernardes, Gonçalo J. L, Spring, David R

“…Transition metal catalysis has emerged as a powerful strategy to expand synthetic flexibility of protein modification. Herein, we report a cationic Ru( ii )…”
Get full text