Search Results - "Kwan, Jason C"

An antifungal polyketide associated with horizontally acquired genes supports symbiont-mediated defense in Lagria villosa beetles by Flórez, Laura V., Scherlach, Kirstin, Miller, Ian J., Rodrigues, Andre, Kwan, Jason C., Hertweck, Christian, Kaltenpoth, Martin

“…Microbial symbionts are often a source of chemical novelty and can contribute to host defense against antagonists. However, the ecological relevance of…”
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Structural Dynamics and Molecular Evolution of the SARS-CoV-2 Spike Protein by Wolf, Kyle A, Kwan, Jason C, Kamil, Jeremy P

“…The ongoing coronavirus disease 2019 (COVID-19) pandemic demonstrates the threat posed by novel coronaviruses to human health. Coronaviruses share a highly…”
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Horizontal Gene Transfer to a Defensive Symbiont with a Reduced Genome in a Multipartite Beetle Microbiome by Waterworth, Samantha C, Flórez, Laura V, Rees, Evan R, Hertweck, Christian, Kaltenpoth, Martin, Kwan, Jason C

“…Symbiotic mutualisms of bacteria and animals are ubiquitous in nature, running a continuum from facultative to obligate from the perspectives of both partners…”
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Genome streamlining and chemical defense in a coral reef symbiosis by Kwan, Jason C, Donia, Mohamed S, Han, Andrew W, Hirose, Euichi, Haygood, Margo G, Schmidt, Eric W

“…Secondary metabolites are ubiquitous in bacteria, but by definition, they are thought to be nonessential. Highly toxic secondary metabolites such as…”
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Discovery and Total Synthesis of Doscadenamide A: A Quorum Sensing Signaling Molecule from a Marine Cyanobacterium by Liang, Xiao, Matthew, Susan, Chen, Qi-Yin, Kwan, Jason C, Paul, Valerie J, Luesch, Hendrik

“…Quorum sensing (QS) plays a critical role in the regulation of bacterial pathogenesis. Doscadenamide A (1a) was isolated from a marine cyanobacterium, its…”
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Bacterial endosymbiosis in a chordate host: long-term co-evolution and conservation of secondary metabolism by Kwan, Jason C, Schmidt, Eric W

“…Intracellular symbiosis is known to be widespread in insects, but there are few described examples in other types of host. These symbionts carry out useful…”
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Environmental metabolomics characterization of modern stromatolites and annotation of ibhayipeptolides by Neuhaus, George F, Aron, Allegra T, Isemonger, Eric W, Petras, Daniel, Waterworth, Samantha C, Madonsela, Luthando S, Gentry, Emily C, Siwe Noundou, Xavier, Kalinski, Jarmo-Charles J, Polyzois, Alexandros, Habiyaremye, Julius C, Redick, Margaret A, Kwan, Jason C, Dorrington, Rosemary A, Dorrestein, Pieter C, McPhail, Kerry L

“…Lithified layers of complex microbial mats known as microbialites are ubiquitous in the fossil record, and modern forms are increasingly identified globally. A…”
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Uncovering Lasonolide A Biosynthesis Using Genome-Resolved Metagenomics by Uppal, Siddharth, Metz, Jackie L, Xavier, René K M, Nepal, Keshav Kumar, Xu, Dongbo, Wang, Guojun, Kwan, Jason C

“…Invertebrates, particularly sponges, have been a dominant source of new marine natural products. For example, lasonolide A (LSA) is a potential anticancer…”
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Comparative Genomics Provides Insight into the Function of Broad-Host Range Sponge Symbionts by Waterworth, Samantha C, Parker-Nance, Shirley, Kwan, Jason C, Dorrington, Rosemary A

“…The fossil record indicates that the earliest evidence of extant marine sponges (phylum Porifera) existed during the Cambrian explosion and that their…”
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Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor by Liu, Yanxia, Salvador, Lilibeth A, Byeon, Seongrim, Ying, Yongcheng, Kwan, Jason C, Law, Brian K, Hong, Jiyong, Luesch, Hendrik

“…Histone deacetylases (HDACs) are validated targets for anticancer therapy as attested by the approval of suberoylanilide hydroxamic acid (SAHA) and romidepsin…”
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Structure and Biosynthesis of the Antibiotic Bottromycin D by Hou, Yanpeng, Tianero, Ma. Diarey B, Kwan, Jason C, Wyche, Thomas P, Michel, Cole R, Ellis, Gregory A, Vazquez-Rivera, Emmanuel, Braun, Doug R, Rose, Warren E, Schmidt, Eric W, Bugni, Tim S

“…Drug resistant infectious diseases are quickly becoming a global health crisis. While Streptomyces spp. have been a major source of antibiotics over the past…”
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Interpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations by Miller, Ian J, Chevrette, Marc G, Kwan, Jason C

“…Genome mining has become an increasingly powerful, scalable, and economically accessible tool for the study of natural product biosynthesis and drug discovery…”
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Grassypeptolides A−C, Cytotoxic Bis-thiazoline Containing Marine Cyclodepsipeptides by Kwan, Jason C, Ratnayake, Ranjala, Abboud, Khalil A, Paul, Valerie J, Luesch, Hendrik

“…Grassypeptolides A−C (1−3), a group of closely related bis-thiazoline containing cyclic depsipeptides, have been isolated from extracts of the marine…”
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Isolation and Biological Evaluation of 8-epi-Malyngamide C from the Floridian Marine Cyanobacterium Lyngbya majuscula by Kwan, Jason C, Teplitski, Max, Gunasekera, Sarath P, Paul, Valerie J, Luesch, Hendrik

“…A new stereoisomer of malyngamide C, 8-epi-malyngamide C (1), and the known compound lyngbic acid [(4E,7S)-7-methoxytetradec-4-enoic acid] were isolated from a…”
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Increased Biosynthetic Gene Dosage in a Genome-Reduced Defensive Bacterial Symbiont by Lopera, Juan, Miller, Ian J, McPhail, Kerry L, Kwan, Jason C

“…A symbiotic lifestyle frequently results in genome reduction in bacteria; the isolation of small populations promotes genetic drift and the fixation of…”
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The Who, Why, and How of Small-Molecule Production in Invertebrate Microbiomes: Basic Insights Fueling Drug Discovery by Kwan, Jason C

“…Bacteria have supplied us with many bioactive molecules for use in medicine and agriculture. However, rates of discovery have decreased as the biosynthetic…”
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Lyngbyastatins 8-10, elastase inhibitors with cyclic depsipeptide scaffolds isolated from the marine cyanobacterium Lyngbya semiplena by Kwan, Jason C, Taori, Kanchan, Paul, Valerie J, Luesch, Hendrik

“…Investigation of an extract from the marine cyanobacterium Lyngbya semiplena, collected in Tumon Bay, Guam, led to the identification of three new…”
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Host control of symbiont natural product chemistry in cryptic populations of the tunicate Lissoclinum patella by Kwan, Jason C, Tianero, Ma Diarey B, Donia, Mohamed S, Wyche, Thomas P, Bugni, Tim S, Schmidt, Eric W

“…Natural products (secondary metabolites) found in marine invertebrates are often thought to be produced by resident symbiotic bacteria, and these products…”
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Total Structure Determination of Grassypeptolide, a New Marine Cyanobacterial Cytotoxin by Kwan, Jason C, Rocca, James R, Abboud, Khalil A, Paul, Valerie J, Luesch, Hendrik

“…A collection of the cyanobacterium Lyngbya confervoides off Grassy Key in Florida yielded grassypeptolide (1), a 31-membered macrocyclic depsipeptide with…”
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A Guide to Extract Spinal Cord for Translational Stem Cell Biology Research: Comparative Analysis of Adult Human, Porcine, and Rodent Spinal Cord Stem Cells by Galuta, Ahmad, Sandarage, Ryan, Ghinda, Diana, Auriat, Angela M., Chen, Suzan, Kwan, Jason C. S., Tsai, Eve C.

“…Improving the clinical translation of animal-based neural stem/progenitor cell (NSPC) therapies to humans requires an understanding of intrinsic human and…”
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