Search Results - "Kwan, Bryan"

Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents by Tari, Leslie W, Li, Xiaoming, Trzoss, Michael, Bensen, Daniel C, Chen, Zhiyong, Lam, Thanh, Zhang, Junhu, Lee, Suk Joong, Hough, Grayson, Phillipson, Doug, Akers-Rodriguez, Suzanne, Cunningham, Mark L, Kwan, Bryan P, Nelson, Kirk J, Castellano, Amanda, Locke, Jeff B, Brown-Driver, Vickie, Murphy, Timothy M, Ong, Voon S, Pillar, Chris M, Shinabarger, Dean L, Nix, Jay, Lightstone, Felice C, Wong, Sergio E, Nguyen, Toan B, Shaw, Karen J, Finn, John

“…Increasing resistance to every major class of antibiotics and a dearth of novel classes of antibacterial agents in development pipelines has created a…”
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Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7‑(Benzimidazol-1-yl)-2,4-diaminoquinazolines by Lam, Thanh, Hilgers, Mark T, Cunningham, Mark L, Kwan, Bryan P, Nelson, Kirk J, Brown-Driver, Vickie, Ong, Voon, Trzoss, Michael, Hough, Grayson, Shaw, Karen Joy, Finn, John

“…A new series of dihydrofolate reductase (DHFR) inhibitors, the 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines, were designed and optimized for antibacterial…”
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Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus by Hensler, Mary E, Jang, Kyoung Hwa, Thienphrapa, Wdee, Vuong, Lisa, Tran, Dan N, Soubih, Evaristus, Lin, Leo, Haste, Nina M, Cunningham, Mark L, Kwan, Bryan P, Shaw, Karen Joy, Fenical, William, Nizet, Victor

“…Anthracimycin is a recently discovered novel marine-derived compound with activity against Bacillus anthracis . We tested anthracimycin against an expanded…”
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Identification of Bacteria-Selective Threonyl-tRNA Synthetase Substrate Inhibitors by Structure-Based Design by Teng, Min, Hilgers, Mark T, Cunningham, Mark L, Borchardt, Allen, Locke, Jeffrey B, Abraham, Sunny, Haley, Gregory, Kwan, Bryan P, Hall, Courtney, Hough, Grayson W, Shaw, Karen J, Finn, John

“…A series of potent and bacteria-selective threonyl-tRNA synthetase (ThrRS) inhibitors have been identified using structure-based drug design. These compounds…”
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Adjuvant Chemotherapy in Older Patients with Gastric Cancer: A Population-Based Cohort Study by Chan, Wing-Lok, Liu, Xiaodong, Wong, Carlos King-Ho, Wong, Michael Siu-Nam, Wong, Ian Yu-Hong, Lam, Ka-On, Yun, Bryan Ho-Kwan, Cheung, Emina Edith, Tse, Rosa Pui-Ying, Chan, Fion, Law, Simon, Kwong, Dora

“…(1) Background: The effectiveness of adjuvant chemotherapy in older patients with gastric cancer after D2-gastrectomy is unclear. This study investigated the…”
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Distinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular synthesis assay by Cunningham, Mark L, Kwan, Bryan P, Nelson, Kirk J, Bensen, Daniel C, Shaw, Karen J

“…The macromolecular synthesis assay was optimized in both S. aureus and E. coli imp and used to define patterns of inhibition of DNA, RNA, protein, and cell…”
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Association of sarcopenia with severe chemotherapy toxicities and survival in patients with advanced gastric cancer by Chan, Wing-Lok, Yun, Ho-Kwan Bryan, Cheung, Emina Edith, Liu, Michelle, Hou, Li-Yu, Lam, Ka-On, Wong, Ian Yu-Hong, Chiu, Wan-Hang Keith, Law, Simon, Kwong, Dora

“…Sarcopenia or skeletal muscle depletion is a poor prognostic factor for gastric cancer (GC). However, existing cutoff values of skeletal muscle index (SMI) for…”
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Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity by Tari, Leslie W., Trzoss, Michael, Bensen, Daniel C., Li, Xiaoming, Chen, Zhiyong, Lam, Thanh, Zhang, Junhu, Creighton, Christopher J., Cunningham, Mark L., Kwan, Bryan, Stidham, Mark, Shaw, Karen J., Lightstone, Felice C., Wong, Sergio E., Nguyen, Toan B., Nix, Jay, Finn, John

“…The bacterial topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE) are essential enzymes that control the topological state of DNA during replication…”
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Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: Development of inhibitors with broad spectrum, Gram-negative antibacterial activity by Trzoss, Micheal, Bensen, Daniel C., Li, Xiaoming, Chen, Zhiyong, Lam, Thanh, Zhang, Junhu, Creighton, Christopher J., Cunningham, Mark L., Kwan, Bryan, Stidham, Mark, Nelson, Kirk, Brown-Driver, Vickie, Castellano, Amanda, Shaw, Karen J., Lightstone, Felice C., Wong, Sergio E., Nguyen, Toan B., Finn, John, Tari, Leslie W.

“…The structurally related bacterial topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE) have long been recognized as prime candidates for the…”
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Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines by Li, Xiaoming, Hilgers, Mark, Cunningham, Mark, Chen, Zhiyong, Trzoss, Michael, Zhang, Junhu, Kohnen, Lucy, Lam, Thanh, Creighton, Chris, GC, Kedar, Nelson, Kirk, Kwan, Bryan, Stidham, Mark, Brown-Driver, Vickie, Shaw, Karen J., Finn, John

“…Dihydrofolate reductase (DHFR) inhibitors such as trimethoprim (TMP) have long played a significant role in the treatment of bacterial infections. Not…”
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