Search Results - "Kwan, Brian W."

Bacterial Persister Cell Formation and Dormancy by WOOD, Thomas K, KNABEL, Stephen J, KWAN, Brian W

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Arrested Protein Synthesis Increases Persister-Like Cell Formation by KWAN, Brian W, VALENTA, John A, BENEDIK, Michael J, WOOD, Thomas K

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Persistence Increases in the Absence of the Alarmone Guanosine Tetraphosphate by Reducing Cell Growth by Chowdhury, Nityananda, Kwan, Brian W., Wood, Thomas K.

“…Most bacterial cells are stressed and as a result, some become tolerant to antibiotics by entering a dormant state known as persistence. The key intracellular…”
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Quorum sensing enhancement of the stress response promotes resistance to quorum quenching and prevents social cheating by García-Contreras, Rodolfo, Nuñez-López, Leslie, Jasso-Chávez, Ricardo, Kwan, Brian W, Belmont, Javier A, Rangel-Vega, Adrián, Maeda, Toshinari, Wood, Thomas K

“…Quorum sensing (QS) coordinates the expression of virulence factors and allows bacteria to counteract the immune response, partly by increasing their tolerance…”
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Phosphodiesterase DosP increases persistence by reducing cAMP which reduces the signal indole by Kwan, Brian W., Osbourne, Devon O., Hu, Ying, Benedik, Michael J., Wood, Thomas K.

“…ABSTRACT Persisters are bacteria that are highly tolerant to antibiotics due to their dormant state and are of clinical significance owing to their role in…”
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Repurposing of Anticancer Drugs for the Treatment of Bacterial Infections by Soo, Valerie W C, Kwan, Brian W, Quezada, Héctor, Castillo-Juárez, Israel, Pérez-Eretza, Berenice, García-Contreras, Silvia Julieta, Martínez-Vázquez, Mariano, Wood, Thomas K, García-Contreras, Rodolfo

“…Despite the fact that bacterial infections are one of the leading causes of death worldwide and that mortality rates are increasing at alarming rates, no new…”
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Combatting bacterial infections by killing persister cells with mitomycin C by Kwan, Brian W, Chowdhury, Nityananda, Wood, Thomas K

“…Persister cells are a multi‐drug tolerant subpopulation of bacteria that contribute to chronic and recalcitrant clinical infections such as cystic fibrosis and…”
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Toxin YafQ increases persister cell formation by reducing indole signalling by Hu, Ying, Kwan, Brian W., Osbourne, Devon O., Benedik, Michael J., Wood, Thomas K.

“…Summary Persister cells survive antibiotic and other environmental stresses by slowing metabolism. Since toxins of toxin/antitoxin (TA) systems have been…”
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Antibiotic-tolerant Staphylococcus aureus Biofilm Persists on Arthroplasty Materials by Urish, Kenneth L., DeMuth, Peter W., Kwan, Brian W., Craft, David W., Ma, Dongzhu, Haider, Hani, Tuan, Rocky S., Wood, Thomas K., Davis, Charles M.

“…Background The continued presence of biofilm may be one cause of the high risk of failure observed with irrigation and débridement with component retention in…”
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The MqsR/MqsA toxin/antitoxin system protects Escherichia coli during bile acid stress by Kwan, Brian W., Lord, Dana M., Peti, Wolfgang, Page, Rebecca, Benedik, Michael J., Wood, Thomas K.

“…Summary Toxin/antitoxin (TA) systems are ubiquitous within bacterial genomes, and the mechanisms of many TA systems are well characterized. As such, several…”
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de novo Synthesis of a Bacterial Toxin/Antitoxin System by Soo, Valerie W. C., Cheng, Hsin-Yao, Kwan, Brian W., Wood, Thomas K.

“…The prevalence of toxin/antitoxin (TA) systems in almost all genomes suggests they evolve rapidly. Here we show that an antitoxin from a type V system (GhoS,…”
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Toxin MqsR cleaves single‐stranded mRNA with various 5' ends by Chowdhury, Nityananda, Kwan, Brian W., McGibbon, Louise C., Babitzke, Paul, Wood, Thomas K.

“…Toxin/antitoxin (TA) systems are the means by which bacterial cells become persistent; that is, those cells that are tolerant to multiple environmental…”
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The MqsR / MqsA toxin/antitoxin system protects E scherichia coli during bile acid stress by Kwan, Brian W., Lord, Dana M., Peti, Wolfgang, Page, Rebecca, Benedik, Michael J., Wood, Thomas K.

“…Summary Toxin/antitoxin ( TA ) systems are ubiquitous within bacterial genomes, and the mechanisms of many TA systems are well characterized. As such, several…”
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Genetic Basis for Persister Cell Formation by Kwan, Brian W

“…The prevalence of bacterial infections poses a significant threat to public health; however, the advent of antibiotics has largely subdued the lethality of…”
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