Search Results - "Kwako, Laura E."

Neuroclinical Framework for the Role of Stress in Addiction by Kwako, Laura E., Koob, George F.

“…Addiction has been conceptualized as a three-stage cycle—binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation—that worsens over time…”
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Factors underlying the neurofunctional domains of the Addictions Neuroclinical Assessment assessed by a standardized neurocognitive battery by Gunawan, Tommy, Luk, Jeremy W., Schwandt, Melanie L., Kwako, Laura E., Vinson, Tonette, Horneffer, Yvonne, George, David T., Koob, George F., Ramchandani, Vijay A., Diazgranados, Nancy, Goldman, David

“…The Addictions Neuroclinical Assessment (ANA) is a neurobiologically-informed framework designed to understand the etiology and heterogeneity of Alcohol Use…”
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Addictions Neuroclinical Assessment: A Neuroscience-Based Framework for Addictive Disorders by Kwako, Laura E, Momenan, Reza, Litten, Raye Z, Koob, George F, Goldman, David

“…This article proposes a heuristic framework for the Addictions Neuroclinical Assessment that incorporates key functional domains derived from the…”
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Addiction Biomarkers: Dimensional Approaches to Understanding Addiction by Kwako, Laura E., Bickel, Warren K., Goldman, David

“…Trends towards dimensional approaches in understanding psychiatric disorders may also be applied to addictive disorders. Advances in our understanding of the…”
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Neurofunctional Domains Derived From Deep Behavioral Phenotyping in Alcohol Use Disorder by Kwako, Laura E, Schwandt, Melanie L, Ramchandani, Vijay A, Diazgranados, Nancy, Koob, George F, Volkow, Nora D, Blanco, Carlos, Goldman, David

“…Objective:The authors evaluated whether three neurofunctional domains proposed to be critical in the addiction cycle, namely, incentive salience, negative…”
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The CRF1 Antagonist Verucerfont in Anxious Alcohol-Dependent Women: Translation of Neuroendocrine, But not of Anti-Craving Effects by Schwandt, Melanie L, Cortes, Carlos R, Kwako, Laura E, George, David T, Momenan, Reza, Sinha, Rajita, Grigoriadis, Dimitri E, Pich, Emilio Merlo, Leggio, Lorenzo, Heilig, Markus

“…Blockade of corticotropin-releasing factor receptor 1 (CRF1) suppresses stress-induced alcohol seeking in rodents, but clinical translation remains. Here, we…”
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The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study by Kwako, Laura E, Spagnolo, Primavera A, Schwandt, Melanie L, Thorsell, Annika, George, David T, Momenan, Reza, Rio, Daniel E, Huestis, Marilyn, Anizan, Sebastien, Concheiro, Marta, Sinha, Rajita, Heilig, Markus

“…Extensive preclinical data implicate corticotropin-releasing hormone (CRH), acting through its CRH1 receptor, in stress- and dependence-induced alcohol…”
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Addictions Neuroclinical Assessment: A reverse translational approach by Kwako, Laura E., Momenan, Reza, Grodin, Erica N., Litten, Raye Z., Koob, George F., Goldman, David

“…Incentive salience, negative emotionality, and executive function are functional domains that are etiologic in the initiation and progression of addictive…”
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PPARγ activation by pioglitazone does not suppress cravings for alcohol, and is associated with a risk of myopathy in treatment seeking alcohol dependent patients: a randomized controlled proof of principle study by Schwandt, Melanie L., Diazgranados, Nancy, Umhau, John C., Kwako, Laura E., George, David T., Heilig, Markus

“…Rationale Proinflammatory processes have been implicated in alcohol addiction, craving, and relapse, while studies in experimental animals have suggested that…”
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FAAH Gene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence by Spagnolo, Primavera A., Ramchandani, Vijay A., Schwandt, Melanie L., Kwako, Laura E., George, David T., Mayo, Leah M., Hillard, Cecilia J., Heilig, Markus

“…Background A common single nucleotide polymorphism (C385A) in the human fatty acid amide hydrolase (FAAH) gene has been associated with decreased distress…”
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Traumatic Brain Injury in Intimate Partner Violence: A Critical Review of Outcomes and Mechanisms by Kwako, Laura E., Glass, Nancy, Campbell, Jacquelyn, Melvin, Kristal C., Barr, Taura, Gill, Jessica M.

“…The prevalence of intimate partner violence (IPV) is striking, as are its consequences to the lives of women. The IPV often includes physical assault, which…”
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History of suicidality and alcohol craving trajectories during inpatient treatment for alcohol use disorder by Janakiraman, Roshni, Gowin, Joshua L., Sloan, Matthew E., Schwandt, Melanie L., Diazgranados, Nancy, Ramchandani, Vijay A., Kwako, Laura E.

“…•Craving levels were measured weekly throughout inpatient AUD treatment.•Suicide attempt history predicted higher craving levels.•Higher craving levels were…”
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Stress vulnerability and alcohol use and consequences: From human laboratory studies to clinical outcomes by Ramchandani, Vijay A., Stangl, Bethany L., Blaine, Sara K., Plawecki, Martin H., Schwandt, Melanie L., Kwako, Laura E., Sinha, Rajita, Cyders, Melissa A., O'Connor, Sean, Zakhari, Samir

“…It is well known that vulnerability to stress is a risk factor for alcohol use disorder (AUD). Chronic alcohol use can result in neuroadaptations in…”
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The neurokinin-1 receptor antagonist aprepitant in co-morbid alcohol dependence and posttraumatic stress disorder: a human experimental study by Kwako, Laura E., George, David T., Schwandt, Melanie L., Spagnolo, Primavera A., Momenan, Reza, Hommer, Daniel W., Diamond, Christine A., Sinha, Rajita, Shaham, Yavin, Heilig, Markus

“…Rationale Posttraumatic stress disorder (PTSD) and alcoholism are frequently comorbid, suggesting the possibility of overlapping neural substrates. The…”
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Characterization of comorbid PTSD in treatment-seeking alcohol dependent inpatients: Severity and personality trait differences by Sells, Joanna R, Waters, Andrew J, Schwandt, Melanie L, Kwako, Laura E, Heilig, Markus, George, David T, Ramchandani, Vijay A

“…Highlights • Treatment-seeking alcohol dependent inpatients with and without PTSD were examined. • Those with PTSD had similar consumption but greater severity…”
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Reply to: Neuroclinical Assessment of Addiction Needs to Incorporate Decision-Making Measures and Ecological Validity by Kwako, Laura E, Momenan, Reza, Litten, Raye Z, Koob, George F, Goldman, David

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Methods for inducing alcohol craving in individuals with co-morbid alcohol dependence and posttraumatic stress disorder: behavioral and physiological outcomes by Kwako, Laura E., Schwandt, Melanie L., Sells, Joanna R., Ramchandani, Vijay A., Hommer, Daniel W., George, David T., Sinha, Rajita, Heilig, Markus

“…Alcohol addiction is a chronic relapsing disorder that presents a substantial public health problem, and is frequently co‐morbid with posttraumatic stress…”
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Childhood sexual abuse and attachment: An intergenerational perspective by Kwako, Laura E., Noll, Jennie G., Putnam, Frank W., Trickett, Penelope K.

“…Childhood sexual abuse (CSA) is a recognized risk factor for various negative outcomes in adult survivors and their offspring. We used the Dynamic-Maturational…”
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2320: HPA axis predictors of cue-induced intravenous alcohol self-administration in non-dependent drinkers by White Brewton, Honoreé, Stangl, Bethany L., Kwako, Laura E., Sinha, Rajita, Ramchandani, Vijay

“…OBJECTIVES/SPECIFIC AIMS: Alcohol craving, particularly in response to stress and alcohol cues, can lead to relapse in alcohol-dependent individuals…”
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Major Depressive Disorder in Persons Exposed to Trauma: Relationship Between Emotional Intelligence and Social Support by Kwako, Laura E., Szanton, Sarah J., Saligan, Leorey N., Gill, Jessica M.

“…BACKGROUND: Traumatic events are often linked to the onset of major depressive disorder (MDD) and for the increase of nonremittance of symptoms; however,…”
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