Search Results - "Kwak, L. W."

Roles of antimicrobial peptides such as defensins in innate and adaptive immunity by Oppenheim, J J, Biragyn, A, Kwak, L W, Yang, D

“…A number of antimicrobial peptides such as defensins have multiple functions in host defence. Defensins are produced not only by phagocytic cells and…”
Get full text

Lenalidomide enhances the protective effect of a therapeutic vaccine and reverses immune suppression in mice bearing established lymphomas by Sakamaki, I, Kwak, L W, Cha, S-c, Yi, Q, Lerman, B, Chen, J, Surapaneni, S, Bateman, S, Qin, H

“…Immunomodulatory drugs (IMiDs) are effective therapeutic agents with direct inhibitory effects on malignant B- and plasma-cells and immunomodulatory effects on…”
Get full text

A randomized trial of a single-dose rasburicase versus five-daily doses in patients at risk for tumor lysis syndrome by Vadhan-Raj, S., Fayad, L.E., Fanale, M.A., Pro, B., Rodriguez, A., Hagemeister, F.B., Bueso-Ramos, C.E., Zhou, X., McLaughlin, P.W., Fowler, N., Shah, J., Orlowski, R.Z., Samaniego, F., Wang, M., Cortes, J.E., Younes, A., Kwak, L.W., Sarlis, N.J., Romaguera, J.E.

“…Tumor lysis syndrome (TLS) is a life-threatening disorder characterized by hyperuricemia and metabolic derangements. The efficacy of rasburicase, administered…”
Get full text

Prospective trial of targeted radioimmunotherapy with Y-90 ibritumomab tiuxetan (Zevalin) for front-line treatment of early-stage extranodal indolent ocular adnexal lymphoma by Esmaeli, B., McLaughlin, P., Pro, B., Samaniego, F., Gayed, I., Hagemeister, F., Romaguera, J., Cabanillas, F., Neelapu, S. S., Banay, R., Fayad, L., Wayne Saville, M., Kwak, L. W.

“…Background: To determine the efficacy and side-effects of 90Y ibritumomab tiuxetan (Zevalin) as front-line treatment in patients with early-stage extranodal…”
Get full text

Bortezomib is synergistic with rituximab and cyclophosphamide in inducing apoptosis of mantle cell lymphoma cells in vitro and in vivo by Wang, M, Han, X H, Zhang, L, Yang, J, Qian, J F, Shi, Y K, Kwak, L W, Romaguera, J, Yi, Q

“…Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma with poor clinical outcome. Although front therapy induces a high rate of complete remission (CR),…”
Get full text

Mediators of Innate Immunity That Target Immature, But Not Mature, Dendritic Cells Induce Antitumor Immunity When Genetically Fused with Nonimmunogenic Tumor Antigens by Biragyn, Arya, Surenhu, Munhsuren, Yang, De, Ruffini, Pier Adelchi, Haines, Bryan Allen, Klyushnenkova, Elena, Oppenheim, Joost J, Kwak, Larry W

“…Chemokine receptors are differentially expressed on immature and mature dendritic cells (DC). Herein, we demonstrate for the first time that murine…”
Get full text

Tumor antigen immunization of sibling stem cell transplant donors in multiple myeloma by NEELAPU, S. S, MUNSHI, N. C, JAGANNATH, S, WATSON, T. M, PENNINGTON, R, REYNOLDS, C, BARLOGIE, B, KWAK, L. W

“…The unique antigenic determinants (idiotype (Id)) of the immunoglobulin secreted by myeloma tumor can serve as a tumor-specific antigen for active…”
Get full text

Neoantigen and tumor antigen-specific immunity transferred from immunized donors is detectable early after allogeneic transplantation in myeloma patients by Foglietta, M, Neelapu, S S, Kwak, L W, Jiang, Y, Nattamai, D, Lee, S-T, Fowler, D H, Sportes, C, Gress, R E, Steinberg, S M, Vence, L M, Radvanyi, L, Dwyer, K C, Qazilbash, M H, Bryant, R N K, Bishop, M R

“…To enhance the therapeutic index of allogeneic hematopoietic SCT (HSCT), we immunized 10 HLA-matched sibling donors before stem cell collection with…”
Get full text

Detection of Tumor Messenger RNA in the Serum of Patients with Malignant Melanoma by KOPRESKI, M. S, BENKO, F. A, KWAK, L. W, GOCKE, C. D

“…Serum RNases are known to be elevated in patients with cancer. Consequently, it is not clear whether human mRNA with sufficient integrity as to permit reverse…”
Get full text

Induction of TLR4-dependent CD8+ T cell immunity by murine β-defensin2 fusion protein vaccines by Park, H.J, Qin, H, Cha, S.C, Sharma, R, Chung, Y, Schluns, K.S, Neelapu, S.S, Overwijk, W.W, Hwu, P, Kwak, L.W

“…Abstract Our laboratory previously described the strategy of fusing chemokine receptor ligands to antigens in order to generate immunogenic DNA vaccines. In…”
Get full text

FAS-antisense 1 lncRNA and production of soluble versus membrane Fas in B-cell lymphoma by Sehgal, L, Mathur, R, Braun, F K, Wise, J F, Berkova, Z, Neelapu, S, Kwak, L W, Samaniego, F

“…Impaired Fas-mediated apoptosis is associated with poor clinical outcomes and cancer chemoresistance. Soluble Fas receptor (sFas), produced by skipping of exon…”
Get full text

Vaccination with Syngeneic, Lymphoma-Derived Immunoglobulin Idiotype Combined with Granulocyte/Macrophage Colony-Stimulating Factor Primes Mice for a Protective T-Cell Response by Kwak, Larry W., Young, Howard A., Pennington, Robin W., Weeks, Steve D.

“…The idiotype of the Ig expressed by a B-cell malignancy (Id) can serve as a unique tumor-specific antigen and as a model for cancer vaccine development. In…”
Get full text

Tumor-specific idiotype vaccines in the treatment of patients with B-cell lymphoma : Long-term results of a clinical trial by HSU, F. J, CASPAR, C. B, CZERWINSKI, D, KWAK, L. W, LILES, T. M, SYRENGELAS, A, TAIDI-LASKOWSKI, B, LEVY, R

“…The surface Ig on each B-cell lymphoma has unique portions (idiotypes), which can be recognized by the immune system. In this study, we immunized patients…”
Get full text

Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity by Kwak, Larry W, Biragyn, Arya, Tani, Kenji, Grimm, Michael C, Weeks, Steven

“…We converted a model, syngeneic, nonimmunogenic tumor antigen into a vaccine by fusing it with a proinflammatory chemokine. Two chemokines, interferon…”
Get full text

Transfer of myeloma idiotype-specific immunity from an actively immunised marrow donor by Kwak, L W, Taub, D D, Duffey, P L, Bensinger, W I, Bryant, E M, Reynolds, C W, Longo, D L

“…The idiotype of myeloma immunoglobulin can be used as a unique tumour-specific antigen. We tested the hypothesis that tumour antigen-specific immunity can be…”
Get more information

Autologous stem-cell transplantation after second-line brentuximab vedotin in relapsed or refractory Hodgkin lymphoma by Herrera, A.F., Palmer, J., Martin, P., Armenian, S., Tsai, N.-C., Kennedy, N., Sahebi, F., Cao, T., Budde, L.E., Mei, M., Siddiqi, T., Popplewell, L., Rosen, S.T., Kwak, L.W., Nademanee, A., Forman, S.J., Chen, R.

“…We previously demonstrated that brentuximab vedotin (BV) used as second-line therapy in patients with Hodgkin lymphoma is a tolerable and effective bridge to…”
Get full text

Tumor-specific recognition of human myeloma cells by idiotype-induced CD8+ T cells by Li, Yiwen, Bendandi, Maurizio, Deng, Yuping, Dunbar, Cynthia, Munshi, Nikhil, Jagannath, Sundar, Kwak, Larry W., Lyerly, H. Kim

“…Immunoglobulin secreted by myeloma cells contains a unique antigenic determinant (idiotype [Id]) that may serve as a tumor-specific antigen. Although…”
Get full text

Clinical Trial Designs for the Early Clinical Development of Therapeutic Cancer Vaccines by SIMON, Richard M, STEINBERG, Seth M, HAMILTON, Michael, HILDESHEIM, Allan, KHLEIF, Samir, KWAK, Larry W, MACKALL, Crystal L, SCHLOM, Jeffrey, TOPALIAN, Suzanne L, BERZOFSKY, Jay A

“…There are major differences between therapeutic tumor vaccines and chemotherapeutic agents that have important implications for the design of early clinical…”
Get full text

Tumor vaccination strategies combined with autologous peripheral stem cell transplantation by KWAK, L. W

“…Despite advances in high-dose therapy with autologous stem cell transplantation for lymphomas, relapse of the underlying disease remains a significant…”
Get full text

Prognostic significance of actual dose intensity in diffuse large-cell lymphoma: results of a tree-structured survival analysis by Kwak, L W, Halpern, J, Olshen, R A, Horning, S J

“…While diffuse large-cell lymphoma (DLCL) is considered to be highly curable with current therapy, treatment failures are observed even with intensive…”
Get more information