Function of Rnd in Insulin signaling pathway

Rnds are atypical members of the Rho small G protein family that inhibit the signaling pathways and functions of RhoA in various cells by activating Rho GAP(GTPase‐activating protein) or inhibiting ROCK(Rho kinases). One of the functions of ROCKs is causing insulin resistance and impairing Insulin s...

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Bibliographic Details
Published in:	The FASEB journal Vol. 21; no. 5; p. A617
Main Authors:	Song, Jin Hwa, Jeon, Hyeona, Lee, Mi Nam, Kwak, Dong Oh, Yea, KyungMoo, Suh, Pann‐Ghill, Ryu, Sung Ho
Format:	Journal Article
Language:	English
Published:	Federation of American Societies for Experimental Biology 01-04-2007
Online Access:	Get full text
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Summary:	Rnds are atypical members of the Rho small G protein family that inhibit the signaling pathways and functions of RhoA in various cells by activating Rho GAP(GTPase‐activating protein) or inhibiting ROCK(Rho kinases). One of the functions of ROCKs is causing insulin resistance and impairing Insulin signaling pathway. There were many reports about that the role of RhoA functions in the cell such as Stress‐Fiber formation and contraction, migration and transformation are repressed by Rnds but no study about Insulin signaling. Here, we find the Rnds can affect Insulin signaling pathway by acting as RhoA antagonists. Moreover, we show the Insulin signal affected the expression level of Rnds in adipocytes. These findings suggest that it is possible that Rnds are involved in Insulin signaling regulations.
ISSN:	0892-6638 1530-6860
DOI:	10.1096/fasebj.21.5.A617