Search Results - "Kvetoslava Vranková"

Pyrazines: Synthesis and Industrial Application of these Valuable Flavor and Fragrance Compounds by Mortzfeld, Frederik B., Hashem, Chiam, Vranková, Kvetoslava, Winkler, Margit, Rudroff, Florian

“…Alkyl pyrazines—other than being extracted from various natural sources such as coffee beans, cocoa beans, and vegetables—can be synthesized by chemical…”
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Biocatalytic Oxidation of Alcohols by Hendrik Puetz, Eva Puchľová, Kvetoslava Vranková, Frank Hollmann

“…Enzymatic methods for the oxidation of alcohols are critically reviewed. Dehydrogenases and oxidases are the most prominent biocatalysts, enabling the…”
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Carboligation towards production of hydroxypentanones by Dobiašová, Hana, Jurkaš, Valentina, Kabátová, Frederika, Horvat, Melissa, Rudroff, Florian, Vranková, Kvetoslava, Both, Peter, Winkler, Margit

“…2-Hydroxy-3-pentanone and 3-hydroxy-2-pentanone are flavor molecules present in various foods, such as cheese, wine, durian, and honey, where they impart…”
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Asymmetric Reduction of Imines with Trichlorosilane, Catalyzed by Sigamide, an Amino Acid-Derived Formamide: Scope and Limitations by Malkov, Andrei V, Vranková, Kvetoslava, Stončius, Sigitas, Kočovský, Pavel

“…Enantioselective reduction of ketimines 6−10 with trichlorosilane can be catalyzed by the N-methyl valine-derived Lewis-basic formamide (S)-23 (Sigamide) with…”
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Towards Biocatalytic Oxidation of Secondary Alcohols to Carbonyl Products of Relevance for Flavors and Fragrances by Puchľová, Eva, Hilberath, Thomas, Vranková, Kvetoslava, Hollmann, Frank

“…Non-enantioselective alcohol dehydrogenases (ADHs) are rarely found in the biocatalysis portfolio. Generally, highly enantioselective ADHs are sought for…”
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On the Selective N-Methylation of BOC-Protected Amino Acids by Malkov, Andrei V, Vranková, Kvetoslava, Černý, Miloslav, Kočovský, Pavel

“…The selective N-methylation of BOC-protected valine 1a with MeI and NaH in THF (i.e., in the presence of a free carboxyl group) has been attributed to the…”
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Separation of (2E,4E)-deca-2,4-dienal from a Biocatalytic Reaction Mixture Using Hydrophobic Adsorbents by Ostrihoňová, Marta, Antošová, Monika, Dobiašová, Hana, Čuchorová, Justína, Vranková, Kvetoslava, Polakovič, Milan

“…Biocatalytic oxidation of a fatty acid preparation by enzymes released from a plant extract provided (2E,4E)-deca-2,4-dienal (2,4-DDAL), a valuable natural…”
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Dynamic Kinetic Resolution in the Asymmetric Synthesis of β-Amino Acids by Organocatalytic Reduction of Enamines with Trichlorosilane by Malkov, Andrei V., Stončius, Sigitas, Vranková, Kvetoslava, Arndt, Matthias, Kočovský, Pavel

“…Resolved dynamically: A new, expedient protocol has been developed for the asymmetric synthesis of β3‐ and β2, 3‐amino acid derivatives from enamine precursors…”
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New organocatalysts for the asymmetric reduction of imines with trichlorosilane by Malkov, Andrei V., Vranková, Kvetoslava, Sigerson, Ralph C., Stončius, Sigitas, Kočovský, Pavel

“…Asymmetric reduction of prochiral ketimines 1a– f with trichlorosilane can be catalyzed by the Lewis-basic formamides ( S)- 4a, b, derived from N-methyl…”
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Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice by Mackenzie, Gerardo G, Huang, Liqun, Alston, Ninche, Ouyang, Nengtai, Vrankova, Kvetoslava, Mattheolabakis, George, Constantinides, Panayiotis P, Rigas, Basil

“…New agents are needed to treat pancreatic cancer, one of the most lethal human malignancies. We synthesized phospho-valproic acid, a novel valproic acid…”
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A Novel Ras Inhibitor (MDC-1016) Reduces Human Pancreatic Tumor Growth in Mice by Mackenzie, Gerardo G, Bartels, Lauren E, Xie, Gang, Papayannis, Ioannis, Alston, Ninche, Vrankova, Kvetoslava, Ouyang, Nengtai, Rigas, Basil

“…Pancreatic cancer has one of the poorest prognoses among all cancers partly because of its persistent resistance to chemotherapy. The currently limited…”
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Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds by Huang, Liqun, Mackenzie, Gerardo G, Sun, Yu, Ouyang, Nengtai, Xie, Gang, Vrankova, Kvetoslava, Komninou, Despina, Rigas, Basil

“…Nonsteroidal anti-inflammatory drugs (NSAID) exhibit antineoplastic properties, but conventional NSAIDs do not fully meet safety and efficacy criteria for use…”
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Phospho-sulindac inhibits pancreatic cancer growth: NFATc1 as a drug resistance candidate by MURRAY, ONIKA T, WONG, CHI C, VRANKOVA, KVETOSLAVA, RIGAS, BASIL

“…Phospho-sulindac (P-S), a promising anticancer agent, is efficacious in pre-clinical models of human cancer and is apparently safe. Here, we studied the effect…”
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Phospho-sulindac inhibits pancreatic cancer growth: NFATcl as a drug resistance candidate by Murray, Onika T, Wong, Chi C, Vrankova, Kvetoslava, Rigas, Basil

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Abstract 4431: NFATc1 silencing increases sensitivity of pancreatic cancer cells to phosphosulindac by Murray, Onika T., Vrankova, Kvetoslava, Johnson, Francis, Rigas, Basil

“…Abstract Pancreatic cancer is the fourth leading cause of cancer-related deaths in the U.S. Current chemotherapeutic agents have limited efficacy and play a…”
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Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: an effect mediated by EGFR inhibition, p53 acetylation and oxidative stress by Huang, Liqun, Wong, Chi C, Mackenzie, Gerardo G, Sun, Yu, Cheng, Ka Wing, Vrankova, Kvetoslava, Alston, Ninche, Ouyang, Nengtai, Rigas, Basil

“…The anticancer properties of aspirin are restricted by its gastrointestinal toxicity and its limited efficacy. Therefore, we synthesized phospho-aspirin (PA-2;…”
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Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice by Mackenzie, Gerardo G, Ouyang, Nengtai, Xie, Gang, Vrankova, Kvetoslava, Huang, Liqun, Sun, Yu, Komninou, Despina, Kopelovich, Levy, Rigas, Basil

“…The nonsteroidal anti-inflammatory drug (NSAID) sulindac and the ornithine decarboxylase (ODC) antagonist difluoromethylornithine (DFMO), individually and…”
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Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system by Sun, Yu, Rowehl, Leahana M, Huang, Liqun, Mackenzie, Gerardo G, Vrankova, Kvetoslava, Komninou, Despina, Rigas, Basil

“…We have recently synthesized phospho-ibuprofen (P-I; MDC-917), a safer derivative of ibuprofen, which has shown anti-cancer activity. We investigated its…”
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Targeting Mitochondrial STAT3 with the Novel Phospho-Valproic Acid by Mackenzie, Gerardo G, Huang, Liqun, Alston, Ninche, Ouyang, Nengtai, Vrankova, Kvetoslava, Mattheolabakis, George, Constantinides, Panayiotis P, Rigas, Basil

“…New agents are needed to treat pancreatic cancer, one of the most lethal human malignancies. We synthesized phospho-valproic acid, a novel valproic acid…”
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A Novel Ras Inhibitor (MDC-1016) Reduces Human Pancreatic Tumor Growth in Mice1 by Mackenzie, Gerardo G, Bartels, Lauren E, Xie, Gang, Papayannis, Ioannis, Alston, Ninche, Vrankova, Kvetoslava, Ouyang, Nengtai, Rigas, Basil

“…Pancreatic cancer has one of the poorest prognoses among all cancers partly because of its persistent resistance to chemotherapy. The currently limited…”
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