Search Results - "Kvarta, Mark D"

Chronic stress induces a selective decrease in AMPA receptor-mediated synaptic excitation at hippocampal temporoammonic-CA1 synapses by Kallarackal, Angy J, Kvarta, Mark D, Cammarata, Erin, Jaberi, Leelah, Cai, Xiang, Bailey, Aileen M, Thompson, Scott M

“…Chronic stress promotes depression, but how it disrupts cognition and mood remains unknown. Chronic stress causes atrophy of pyramidal cell dendrites in the…”
Get full text

Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression by Cai, Xiang, Kallarackal, Angy J, Kvarta, Mark D, Goluskin, Sasha, Gaylor, Kaitlin, Bailey, Aileen M, Lee, Hey-Kyoung, Huganir, Richard L, Thompson, Scott M

“…The authors find that serotonin, acting through 5-HT 1B receptors, potentiates temporoammonic pathway–to–CA1 cell excitatory synapses in the hippocampus…”
Get full text

The additive impact of cardio‐metabolic disorders and psychiatric illnesses on accelerated brain aging by Ryan, Meghann C., Hong, L. Elliot, Hatch, Kathryn S., Gao, Si, Chen, Shuo, Haerian, Krystl, Wang, Jingtao, Goldwaser, Eric L., Du, Xiaoming, Adhikari, Bhim M., Bruce, Heather, Hare, Stephanie, Kvarta, Mark D., Jahanshad, Neda, Nichols, Thomas E., Thompson, Paul M., Kochunov, Peter

“…Severe mental illnesses (SMI) including major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia spectrum disorder (SSD) elevate accelerated…”
Get full text

Association between brain similarity to severe mental illnesses and comorbid cerebral, physical, and cognitive impairments by Ma, Yizhou, Kvarta, Mark D., Adhikari, Bhim M., Chiappelli, Joshua, Du, Xiaoming, van der Vaart, Andrew, Goldwaser, Eric L., Bruce, Heather, Hatch, Kathryn S., Gao, Si, Summerfelt, Ann, Jahanshad, Neda, Thompson, Paul M., Nichols, Thomas E., Hong, L. Elliot, Kochunov, Peter

“…•Non-psychiatric adults were clustered by brain similarity to severe mental illness.•Clusters with more similarity had higher volume of white matter…”
Get full text

Comparing empirical kinship derived heritability for imaging genetics traits in the UK biobank and human connectome project by Gao, Si, Donohue, Brian, Hatch, Kathryn S., Chen, Shuo, Ma, Tianzhou, Ma, Yizhou, Kvarta, Mark D., Bruce, Heather, Adhikari, Bhim M., Jahanshad, Neda, Thompson, Paul M., Blangero, John, Hong, L. Elliot, Medland, Sarah E., Ganjgahi, Habib, Nichols, Thomas E., Kochunov, Peter

“…Imaging genetics analyses use neuroimaging traits as intermediate phenotypes to infer the degree of genetic contribution to brain structure and function in…”
Get full text

Cerebral blood flow and cardiovascular risk effects on resting brain regional homogeneity by Adhikari, Bhim M., Hong, L. Elliot, Zhao, Zhiwei, Wang, Danny J.J., Thompson, Paul M., Jahanshad, Neda, Zhu, Alyssa H., Holiga, Stefan, Turner, Jessica A., van Erp, Theo G.M., Calhoun, Vince D., Hatch, Kathryn S., Bruce, Heather, Hare, Stephanie M., Chiappelli, Joshua, Goldwaser, Eric L., Kvarta, Mark D., Ma, Yizhou, Du, Xiaoming, Nichols, Thomas E., Shuldiner, Alan R., Mitchell, Braxton D., Dukart, Juergen, Chen, Shuo, Kochunov, Peter

“…Regional homogeneity (ReHo) is a measure of local functional brain connectivity that has been reported to be altered in a wide range of neuropsychiatric…”
Get full text

Peri-Ictal Changes in Depression and Anxiety in Persons With Epileptic and Non-epileptic Seizures by Hopp, Jennifer, Pahlavan, Autusa, Richert, Mary, Grimes, Kathryn, Turlington, Kate, Cassady, Maureen, Kvarta, Mark D., Thompson, Scott M.

“…ObjectiveWe tested the hypothesis that epileptic, but not non-epileptic, seizures would produce an improvement in comorbid depression and anxiety symptoms in…”
Get full text

Demyelination as a harbinger of lymphoma: a case report and review of primary central nervous system lymphoma preceded by multifocal sentinel demyelination by Kvarta, Mark D, Sharma, Deva, Castellani, Rudolph J, Morales, Robert E, Reich, Stephen G, Kimball, Amy S, Shin, Robert K

“…Primary central nervous system lymphoma (PCNSL) may rarely be preceded by "sentinel demyelination," a pathologic entity characterized by histologically…”
Get full text

Mapping local and long-distance resting connectivity markers of TMS-related inhibition reduction in schizophrenia by Hare, Stephanie M., Du, Xiaoming, Adhikari, Bhim M., Chen, Shuo, Mo, Chen, Summerfelt, Ann, Kvarta, Mark D., Garcia, Laura, Kochunov, Peter, Elliot Hong, L.

“…•Exploration of neural basis of the short-interval intracortical inhibition (SICI) marker using paired-pulse TMS in individuals with schizophrenia.•Use of a…”
Get full text

Sex differences in antidepressant efficacy by LeGates, Tara A, Kvarta, Mark D, Thompson, Scott M

“…Sex differences have been observed across many psychiatric diseases, especially mood disorders. For major depression, the most prevalent psychiatric disorder,…”
Get full text

Multiple dimensions of stress vs. genetic effects on depression by Kvarta, Mark D., Bruce, Heather A., Chiappelli, Joshua, Hare, Stephanie M., Goldwaser, Eric L., Sewell, Jessica, Sampath, Hemalatha, Lightner, Samantha, Marshall, Wyatt, Hatch, Kathryn, Humphries, Elizabeth, Ament, Seth, Shuldiner, Alan R., Mitchell, Braxton D., McMahon, Francis J., Kochunov, Peter, Hong, L. Elliot

“…Many psychiatric disorders including depression involve complex interactions of genetics and environmental stressors. Environmental influence is challenging to…”
Get full text

Comparison of regional brain deficit patterns in common psychiatric and neurological disorders as revealed by big data by Kochunov, Peter, Ryan, Meghann C., Yang, Qifan, Hatch, Kathryn S., Zhu, Alyssa, Thomopoulos, Sophia I., Jahanshad, Neda, Schmaal, Lianne, Thompson, Paul M., Chen, Shuo, Du, Xiaoming, Adhikari, Bhim M., Bruce, Heather, Hare, Stephanie, Goldwaser, Eric L., Kvarta, Mark D., Nichols, Thomas E., Hong, L. Elliot

“…•RVI for MDD and AD was derived based on large meta-analytical findings.•RVI-MDD and AD were significantly elevated in UKBB subjects with respective…”
Get full text

Effects of independent versus dependent stressful life events on major symptom domains of schizophrenia by Ma, Yizhou, Chiappelli, Joshua, Kvarta, Mark D., Bruce, Heather, van der Vaart, Andrew, Goldwaser, Eric L., Du, Xiaoming, Sampath, Hemalatha, Lightner, Samantha, Endres, Jane, Yusuf, Akram, Yuen, Alexa, Narvaez, Samantha, Campos-Saravia, Danny, Kochunov, Peter, Hong, L. Elliot

“…We evaluated two models to link stressful life events (SLEs) with the psychopathology of schizophrenia spectrum disorders (SSD). We separated SLEs into…”
Get full text

Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses by LeGates, Tara A., Kvarta, Mark D., Tooley, Jessica R., Francis, T. Chase, Lobo, Mary Kay, Creed, Meaghan C., Thompson, Scott M.

“…Reward drives motivated behaviours and is essential for survival, and therefore there is strong evolutionary pressure to retain contextual information about…”
Get full text

Illuminating a path from light to depression by LeGates, Tara A., Kvarta, Mark D.

“…Our light environment can strongly influence our mental health. Kai An and colleagues dissect the neuronal circuit mediating depression-related behaviors…”
Get full text

Esketamine in depression: putative biomarkers from clinical research by Johnston, Jenessa N, Zarate, Jr, Carlos A, Kvarta, Mark D

“…The discovery of racemic (R, S)-ketamine as a rapid-acting antidepressant and the subsequent FDA approval of its (S)-enantiomer, esketamine, for…”
Get full text

Impact of lifetime stressor exposure on neuroenergetics in schizophrenia spectrum disorders by Chiappelli, Joshua, Savransky, Anya, Ma, Yizhou, Gao, Si, Kvarta, Mark D., Kochunov, Peter, Slavich, George M., Hong, L. Elliot

“…N-acetylasparate and lactate are two prominent brain metabolites closely related to mitochondrial functioning. Prior research revealing lower levels of NAA and…”
Get full text

Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses by Kvarta, Mark D, Bradbrook, Keighly E, Dantrassy, Hannah M, Bailey, Aileen M, Thompson, Scott M

“…Chronic stress is thought to impart risk for depression via alterations in brain structure and function, but contributions of specific mediators in generating…”
Get full text

Ancestral, Pregnancy, and Negative Early-Life Risks Shape Children’s Brain (Dis)similarity to Schizophrenia by Kochunov, Peter, Ma, Yizhou, Hatch, Kathryn S., Gao, Si, Acheson, Ashley, Jahanshad, Neda, Thompson, Paul M., Adhikari, Bhim M., Bruce, Heather, Van der vaart, Andrew, Chiappelli, Joshua, Du, Xiaoming, Sotiras, Aris, Kvarta, Mark D., Ma, Tianzhou, Chen, Shuo, Hong, L. Elliot

“…Familial, obstetric, and early-life environmental risks for schizophrenia spectrum disorder (SSD) alter normal cerebral development, leading to the formation…”
Get full text

Depression, stress and regional cerebral blood flow by Chiappelli, Joshua, Adhikari, Bhim M, Kvarta, Mark D, Bruce, Heather A, Goldwaser, Eric L, Ma, Yizhou, Chen, Shuo, Ament, Seth, Shuldiner, Alan R, Mitchell, Braxton D, Kochunov, Peter, Wang, Danny JJ, Hong, L Elliot

“…Decreased cerebral blood flow (CBF) may be an important mechanism associated with depression. In this study we aimed to determine if the association of CBF and…”
Get full text