Search Results - "Kvach, Maksim V"

Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A by Kurup, Harikrishnan M, Kvach, Maksim V, Harjes, Stefan, Jameson, Geoffrey B, Harjes, Elena, Filichev, Vyacheslav V

“…The APOBEC3 (APOBEC3A-H) enzyme family as a part of the human innate immune system deaminates cytosine to uracil in single-stranded DNA (ssDNA) and thereby…”
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Synthesis of 1,4-azaphosphinine nucleosides and evaluation as inhibitors of human cytidine deaminase and APOBEC3A by Kvach, Maksim V, Harjes, Stefan, Kurup, Harikrishnan M, Jameson, Geoffrey B, Harjes, Elena, Filichev, Vyacheslav V

“…Nucleoside and polynucleotide cytidine deaminases (CDAs), such as CDA and APOBEC3, share a similar mechanism of cytosine to uracil conversion. In 1984,…”
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Automated Solid-Phase Click Synthesis of Oligonucleotide Conjugates: From Small Molecules to Diverse N‑Acetylgalactosamine Clusters by Farzan, Valentina M, Ulashchik, Egor A, Martynenko-Makaev, Yury V, Kvach, Maksim V, Aparin, Ilya O, Brylev, Vladimir A, Prikazchikova, Tatiana A, Maklakova, Svetlana Yu, Majouga, Alexander G, Ustinov, Alexey V, Shipulin, German A, Shmanai, Vadim V, Korshun, Vladimir A, Zatsepin, Timofei S

“…We developed a novel technique for the efficient conjugation of oligonucleotides with various alkyl azides such as fluorescent dyes, biotin, cholesterol,…”
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Determination of Concentration of Amphiphilic Polymer Molecules on the Surface of Encapsulated Semiconductor Nanocrystals by Fedosyuk, Aleksandra, Radchanka, Aliaksandra, Antanovich, Artsiom, Prudnikau, Anatol, Kvach, Maksim V, Shmanai, Vadim, Artemyev, Mikhail

“…We present a method for the determination of the average number of polymer molecules on the surface of AIIBVI luminescent core–shell nanocrystals (CdSe/ZnS,…”
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Small-Angle X-ray Scattering (SAXS) Measurements of APOBEC3G Provide Structural Basis for Binding of Single-Stranded DNA and Processivity by Barzak, Fareeda M, Ryan, Timothy M, Mohammadzadeh, Nazanin, Harjes, Stefan, Kvach, Maksim V, Kurup, Harikrishnan M, Krause, Kurt L, Chelico, Linda, Filichev, Vyacheslav V, Harjes, Elena, Jameson, Geoffrey B

“…APOBEC3 enzymes are polynucleotide deaminases, converting cytosine to uracil on single-stranded DNA (ssDNA) and RNA as part of the innate immune response…”
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Small-Angle X-ray Scattering Models of APOBEC3B Catalytic Domain in a Complex with a Single-Stranded DNA Inhibitor by Barzak, Fareeda M, Ryan, Timothy M, Kvach, Maksim V, Kurup, Harikrishnan M, Aihara, Hideki, Harris, Reuben S, Filichev, Vyacheslav V, Harjes, Elena, Jameson, Geoffrey B

“…In normal cells APOBEC3 (A3A-A3H) enzymes as part of the innate immune system deaminate cytosine to uracil on single-stranded DNA (ssDNA) to scramble DNA in…”
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4′,5′-Dichloro-2′,7′-dimethoxy-5(6)-carboxyfluorescein (JOE): Synthesis and Spectral Properties of Oligonucleotide Conjugates by Tsybulsky, Dmitry A, Kvach, Maksim V, Stepanova, Irina A, Korshun, Vladimir A, Shmanai, Vadim V

“…A convenient procedure for the preparation of the fluorescent dye 4′,5′-dichloro-2′,7′-dimethoxy-5(6)-carboxyfluorescein (JOE) is reported; the overall yield…”
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Practical Synthesis of Isomerically Pure 5- and 6-Carboxytetramethylrhodamines, Useful Dyes for DNA Probes by Kvach, Maksim V, Stepanova, Irina A, Prokhorenko, Igor A, Stupak, Aleksander P, Bolibrukh, Dmitry A, Korshun, Vladimir A, Shmanai, Vadim V

“…Simple and scalable synthesis of 5- and 6-carboxytetramethylrhodamines (TAMRAs) is reported. Acylation of 3-dimethylaminophenol with 1,2,4-benzenetricarboxylic…”
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Design, Synthesis, and Evaluation of a Cross-Linked Oligonucleotide as the First Nanomolar Inhibitor of APOBEC3A by Kurup, Harikrishnan M., Kvach, Maksim V., Harjes, Stefan, Barzak, Fareeda M., Jameson, Geoffrey B., Harjes, Elena, Filichev, Vyacheslav V.

“…Drug resistance is a major problem associated with anticancer chemo- and immunotherapies. Recent advances in the understanding of resistance mechanisms have…”
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Selective inhibition of APOBEC3 enzymes by single-stranded DNAs containing 2'-deoxyzebularine by Barzak, Fareeda M, Harjes, Stefan, Kvach, Maksim V, Kurup, Harikrishnan M, Jameson, Geoffrey B, Filichev, Vyacheslav V, Harjes, Elena

“…To restrict pathogens, in a normal human cell, APOBEC3 enzymes mutate cytosine to uracil in foreign single-stranded DNAs. However, in cancer cells, APOBEC3B…”
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Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues by Kvach, Maksim V, Barzak, Fareeda M, Harjes, Stefan, Schares, Henry A. M, Jameson, Geoffrey B, Ayoub, Alex M, Moorthy, Ramkumar, Aihara, Hideki, Harris, Reuben S, Filichev, Vyacheslav V, Harki, Daniel A, Harjes, Elena

“…APOBEC3 enzymes form part of the innate immune system by deaminating cytosine to uracil in single-stranded DNA (ssDNA) and thereby preventing the spread of…”
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Differential Inhibition of APOBEC3 DNA‐Mutator Isozymes by Fluoro‐ and Non‐Fluoro‐Substituted 2′‐Deoxyzebularine Embedded in Single‐Stranded DNA by Kvach, Maksim V., Barzak, Fareeda M., Harjes, Stefan, Schares, Henry A. M., Kurup, Harikrishnan M., Jones, Katherine F., Sutton, Lorraine, Donahue, John, D'Aquila, Richard T., Jameson, Geoffrey B., Harki, Daniel A., Krause, Kurt L., Harjes, Elena, Filichev, Vyacheslav V.

“…The APOBEC3 (APOBEC3A‐H) enzyme family is part of the human innate immune system that restricts pathogens by scrambling pathogenic single‐stranded (ss) DNA by…”
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Novel homo Yin-Yang probes improve sensitivity in RT-qPCR detection of low copy HIV RNA by Farzan, Valentina M., Kvach, Maksim V., Aparin, Ilya O., Kireev, Dmitry E., Prikazchikova, Tatiana A., Ustinov, Alexey V., Shmanai, Vadim V., Shipulin, German A., Korshun, Vladimir A., Zatsepin, Timofei S.

“…Nucleic acids labeled with a fluorophore/quencher pair are widely used as probes in biomedical research and molecular diagnostics. Here we synthesized novel…”
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Azide Phosphoramidite in Direct Synthesis of Azide-Modified Oligonucleotides by Fomich, Maksim A, Kvach, Maksim V, Navakouski, Maksim J, Weise, Christoph, Baranovsky, Alexander V, Korshun, Vladimir A, Shmanai, Vadim V

“…Azide and phosphoramidite functions were found to be compatible within one molecule and stable for months in solution kept frozen at −20 °C. An azide-carrying…”
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Design of molecular beacons: 3' couple quenchers improve fluorogenic properties of a probe in real-time PCR assay by Ryazantsev, Dmitry Y, Kvach, Maksim V, Tsybulsky, Dmitry A, Prokhorenko, Igor A, Stepanova, Irina A, Martynenko, Yury V, Gontarev, Sergey V, Shmanai, Vadim V, Zavriev, Sergey K, Korshun, Vladimir A

“…Convenient preparation of fluorogenic hairpin DNA probes (molecular beacons) carrying a pair of FAM fluorophores (located close to 5'-terminus of the probe) or…”
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Two-dye and one- or two-quencher DNA probes for real-time PCR assay: synthesis and comparison with a TaqMan™ probe by Ryazantsev, Dmitry Y., Tsybulsky, Dmitry A., Prokhorenko, Igor A., Kvach, Maksim V., Martynenko, Yury V., Philipchenko, Pavel M., Shmanai, Vadim V., Korshun, Vladimir A., Zavriev, Sergey K.

“…A typical TaqMan™ real-time PCR probe contains a 5′-fluorescent dye and a 3′-quencher. In the course of the amplification, the probe is degraded starting from…”
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A Convenient Synthesis of Cyanine Dyes: Reagents for the Labeling of Biomolecules by Kvach, Maksim V., Ustinov, Alexey V., Stepanova, Irina A., Malakhov, Andrei D., Skorobogatyi, Mikhail V., Shmanai, Vadim V., Korshun, Vladimir A.

“…Four tetramethylindo(di)carbocyanine‐derived carboxylicacids have been prepared using a modified one‐pot procedure for the dye assembly. The acids were…”
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Molecular beacons with JOE dye: Influence of linker and 3′ couple quencher by Tsybulsky, Dmitry A., Kvach, Maksim V., Ryazantsev, Dmitry Y., Aparin, Ilya O., Stakheev, Alexander A., Prokhorenko, Igor A., Martynenko, Yury V., Gontarev, Sergey V., Formanovsky, Andrey A., Zatsepin, Timofei S., Shmanai, Vadim V., Korshun, Vladimir A., Zavriev, Sergey K.

“…Molecular beacons carrying JOE dye (4′,5′-dichloro-2′,7′-dimethoxy-6-carboxyfluorescein) on a rigid or flexible linker and one or two BHQ1 quenchers have been…”
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5(6)-Carboxyfluorescein Revisited:  New Protecting Group, Separation of Isomers, and their Spectral Properties on Oligonucleotides by Kvach, Maksim V, Tsybulsky, Dmitry A, Ustinov, Alexey V, Stepanova, Irina A, Bondarev, Stanislav L, Gontarev, Sergey V, Korshun, Vladimir A, Shmanai, Vadim V

“…Pentafluorophenyl esters of 5- and 6-carboxyfluorescein-3‘,6‘-O-dipivalate can be easily separated in multigram quantities by column chromatography. The…”
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Non-nucleoside phosphoramidites of xanthene dyes (FAM, JOE, and TAMRA) for oligonucleotide labeling by Kvach, Maksim V, Tsybulsky, Dmitry A, Shmanai, Vadim V, Prokhorenko, Igor A, Stepanova, Irina A, Korshun, Vladimir A

“…This unit describes the preparation of 5- and 6-carboxy derivatives of the xanthene fluorescent dyes fluorescein (FAM),…”
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