Search Results - "Kuzyk, Michael A."

Multiple Reaction Monitoring-based, Multiplexed, Absolute Quantitation of 45 Proteins in Human Plasma by Kuzyk, Michael A., Smith, Derek, Yang, Juncong, Cross, Tyra J., Jackson, Angela M., Hardie, Darryl B., Anderson, N. Leigh, Borchers, Christoph H.

“…Mass spectrometry-based multiple reaction monitoring (MRM) quantitation of proteins can dramatically impact the discovery and quantitation of biomarkers via…”
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A Quantitative Study of the Effects of Chaotropic Agents, Surfactants, and Solvents on the Digestion Efficiency of Human Plasma Proteins by Trypsin by Proc, Jennifer L, Kuzyk, Michael A, Hardie, Darryl B, Yang, Juncong, Smith, Derek S, Jackson, Angela M, Parker, Carol E, Borchers, Christoph H

“…Plasma biomarkers studies are based on the differential expression of proteins between different treatment groups or between diseased and control populations…”
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The effect of pre-analytical variability on the measurement of MRM-MS-based mid- to high-abundance plasma protein biomarkers and a panel of cytokines by Aguilar-Mahecha, Adriana, Kuzyk, Michael A, Domanski, Dominik, Borchers, Christoph H, Basik, Mark

“…Blood sample processing and handling can have a significant impact on the stability and levels of proteins measured in biomarker studies. Such pre-analytical…”
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Interaction of Cyclin-Dependent Kinase 12/CrkRS with Cyclin K1 Is Required for the Phosphorylation of the C-Terminal Domain of RNA Polymerase II by Cheng, S.-W. Grace, Kuzyk, Michael A., Moradian, Annie, Ichu, Taka-Aki, Chang, Vicky C.-D., Tien, Jerry F., Vollett, Sarah E., Griffith, Malachi, Marra, Marco A., Morin, Gregg B.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Targeted proteomics using selected reaction monitoring reveals the induction of specific terpene synthases in a multi-level study of methyl jasmonate-treated Norway spruce (Picea abies) by Zulak, Katherine G, Lippert, Dustin N, Kuzyk, Michael A, Domanski, Dominik, Chou, Tina, Borchers, Christoph H, Bohlmann, Jörg

“…Induction of terpene synthase (TPS) gene expression and enzyme activity is known to occur in response to various chemical and biological stimuli in several…”
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A comparison of MS/MS‐based, stable‐isotope‐labeled, quantitation performance on ESI‐quadrupole TOF and MALDI‐TOF/TOF mass spectrometers by Kuzyk, Michael A., Ohlund, Leanne B., Elliott, Monica H., Smith, Derek, Qian, Hong, Delaney, Allen, Hunter, Christie L., Borchers, Christoph H.

“…The peptide‐based quantitation accuracy and precision of LC‐ESI (QSTAR Elite) and LC‐MALDI (4800 MALDI TOF/TOF) were compared by analyzing identical…”
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Cytosolic protein interactions of the schizophrenia susceptibility gene dysbindin by Mead, Carri-Lyn R, Kuzyk, Michael A, Moradian, Annie, Wilson, Gary M, Holt, Robert A, Morin, Gregg B

“…J. Neurochem. (2010) 113, 1491-1503. Using immunoprecipitation, mass spectrometry, and western blot analysis we investigated cytosolic protein interactions of…”
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An integrated genomic, proteomic and biochemical analysis of (+)‐3‐carene biosynthesis in Sitka spruce (Picea sitchensis) genotypes that are resistant or susceptible to white pine weevil by Hall, Dawn E., Robert, Jeanne A., Keeling, Christopher I., Domanski, Dominik, Quesada, Alfonso Lara, Jancsik, Sharon, Kuzyk, Michael A., Hamberger, Britta, Borchers, Christoph H., Bohlmann, Jörg

“…Summary Conifers are extremely long‐lived plants that have evolved complex chemical defenses in the form of oleoresin terpenoids to resist attack from…”
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An efficacious recombinant subunit vaccine against the salmonid rickettsial pathogen Piscirickettsia salmonis by Kuzyk, Michael A., Burian, Ján, Machander, Dave, Dolhaine, Daphne, Cameron, Stephen, Thornton, Julian C., Kay, William W.

“…Piscirickettsia salmonis is the aetiological agent of salmonid rickettsial septicaemia, an economically devastating rickettsial disease of farmed salmonids…”
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Development of MRM-based assays for the absolute quantitation of plasma proteins by Kuzyk, Michael A, Parker, Carol E, Domanski, Dominik, Borchers, Christoph H

“…Multiple reaction monitoring (MRM), sometimes called selected reaction monitoring (SRM), is a directed tandem mass spectrometric technique performed on to…”
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Identification of Leishmania‐specific protein phosphorylation sites by LC‐ESI‐MS/MS and comparative genomics analyses by Hem, Sonia, Gherardini, Pier Federico, Fortéa, José Osorio y, Hourdel, Veronique, Morales, Miguel A, Watanabe, Reiko, Pescher, Pascale, Kuzyk, Michael A, Smith, Derek, Borchers, Christoph H, Zilberstein, Dan, Helmer‐Citterich, Manuela, Namane, Abdelkader, Späth, Gerald F

“…Human pathogenic protozoa of the genus Leishmania undergo various developmental transitions during the infectious cycle that are triggered by changes in the…”
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Identification of Serum Amyloid A as a Biomarker to Distinguish Prostate Cancer Patients with Bone Lesions by Le, Lyly, Chi, Kim, Tyldesley, Scott, Flibotte, Stephane, Diamond, Deborah L, Kuzyk, Michael A, Sadar, Marianne D

“…Prostate cancer has a propensity to metastasize to the bone. Currently, there are no curative treatments for this stage of the disease. Sensitive biomarkers…”
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The use of multiplexed MRM for the discovery of biomarkers to differentiate iron-deficiency anemia from anemia of inflammation by Domanski, Dominik, Cohen Freue, Gabriela V., Sojo, Luis, Kuzyk, Michael A., Ratkay, Leslie, Parker, Carol E., Goldberg, Y. Paul, Borchers, Christoph H.

“…In this study we demonstrate the use of a multiplexed MRM-based assay to distinguish among normal (NL) and iron-metabolism disorder mouse models, particularly,…”
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Developing an iMALDI method by Shah, Brinda, Reid, Jennifer D, Kuzyk, Michael A, Parker, Carol E, Borchers, Christoph H

“…The iMALDI (immuno-MALDI) technique involves the affinity capture of target peptides from an enzymatic digest of a sample, followed by the direct analysis of…”
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An integrated genomic, proteomic and biochemical analysis of (+)a3acarene biosynthesis in Sitka spruce (Picea sitchensis) genotypes that are resistant or susceptible to white pine weevil by Hall, Dawn E, Robert, Jeanne A, Keeling, Christopher I, Domanski, Dominik, Quesada, Alfonso Lara, Jancsik, Sharon, Kuzyk, Michael A, Hamberger, Britta, Borchers, Christoph H, Bohlmann, JAPGrg

“…Conifers are extremely long-lived plants that have evolved complex chemical defenses in the form of oleoresin terpenoids to resist attack from pathogens and…”
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The CrkRS/CDK12 kinase is activated by a novel isoform of Cyclin K and phosphorylates the C‐terminal domain of RNA Pol II by Morin, Gregg B, Kuzyk, Michael A, Tien, Jerry F, Schaeffer, Emily, Cheng, S.‐W. Grace

“…Abstract only CrkRS (Cdc2‐related kinase, Arg/Ser), or CDK12 (Cyclin Dependent Kinase 12), is a ser/thr kinase believed to coordinate transcription and RNA…”
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The use of multiplexed MRM for the discovery of biomarkers to differentiate iron-deficiency anemia from anemia of inflammation : Understanding genome regulation and geneti diversity by mass spectrometry by DOMANSKI, Dominik, COHEN FREUE, Gabriela V, SOJO, Luis, KUZYK, Michael A, RATKAY, Leslie, PARKER, Carol E, PAUL GOLDBERG, Y, BORCHERS, Christoph H

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Antigenic characterization of the salmonid pathogen Piscirickettsia salmonis by Kuzyk, M.A. (University of Victoria, BC, Canada.), Thorton, J.C, Kay, W.W

“…Piscirickettsia salmonis, the etiological agent of salmonid rickettsial septicemia, was purified from infected immortal chinook salmon (Oncorhynchus…”
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