Search Results - "Kuzumaki, Noboru"

Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC by KUSANO, Hajime, SHIMIZU, Shigeomi, KOYA, Richard Chikara, FUJITA, Hisakazu, KAMADA, Shinji, KUZUMAKI, Noboru, TSUJIMOTO, Yoshihide

“…Gelsolin is a Ca2+-dependent actin-regulatory protein that modulates actin assembly and disassembly, and is believed to regulate cell motility through…”
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Gelsolin Inhibits Apoptosis by Blocking Mitochondrial Membrane Potential Loss and Cytochrome c Release by Koya, Richard Chikara, Fujita, Hisakazu, Shimizu, Shigeomi, Ohtsu, Makoto, Takimoto, Masato, Tsujimoto, Yoshihide, Kuzumaki, Noboru

“…Apoptotic cell death, characterized by chromatin condensation, nuclear fragmentation, cell membrane blebbing, and apoptotic body formation, is also accompanied…”
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Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification by Nakagawa, Koji, Kuzumaki, Noboru

“…Megakaryoblastic leukemia 1 (MKL1) was originally identified as a gene translocated in megakaryoblastic leukemia. It has been shown that MKL1 functions as a…”
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Gelsolin functions as a metasatsis suppressor in B16‐BL6 mouse melanoma cells and requirement of the carboxyl‐terminus for its effect by Fujita, Hisakazu, Okada, Futoshi, Hamada, Jun‐ichi, Hosokawa, Masuo, Moriuchi, Tetsuya, Chikara Koya, Richard, Kuzumaki, Noboru

“…Gelsolin, an actin‐binding protein, is implicated as a critical regulator in cell motility. In addition, we have reported that cellular levels of gelsolin are…”
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A Cloning Method for Caspase Substrates that Uses the Yeast Two-Hybrid System: Cloning of the Antiapoptotic Gene Gelsolin by Kamada, Shinji, Kusano, Hajime, Fujita, Hisakazu, Ohtsu, Makoto, Koya, Richard Chikara, Kuzumaki, Noboru, Tsujimoto, Yoshihide

“…Caspase-mediated proteolysis is a critical and central element of the apoptotic process; therefore, it is important to identify the downstream molecular…”
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Differential Phospholipase D Activation by Bradykinin and Sphingosine 1-Phosphate in NIH 3T3 Fibroblasts Overexpressing Gelsolin by Banno, Yoshiko, Fujita, Hisakazu, Ono, Yoshitaka, Nakashima, Shigeru, Ito, Yuzuru, Kuzumaki, Noboru, Nozawa, Yoshinori

“…Gelsolin, an actin-binding protein, shows a strong ability to bind to phosphatidylinositol 4,5-bisphosphate (PIP2). Here we showed in in vitroexperiments that…”
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An improved intravesical model using human bladder cancer cell lines to optimize gene and other therapies by Watanabe, T, Shinohara, N, Sazawa, A, Harabayashi, T, Ogiso, Y, Koyanagi, T, Takiguchi, M, Hashimoto, A, Kuzumaki, N, Yamashita, M, Tanaka, M, Grossman, H B, Benedict, W F

“…Orthotopic implantation of human bladder cancer cells into immunodeficient mice is an important tool for studying the biology and effects of therapy…”
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The protein encoded by cancer/testis gene D40/AF15q14 is localized in spermatocytes, acrosomes of spermatids and ejaculated spermatozoa by Sasao, Takumi, Itoh, Naoki, Takano, Hiroko, Watanabe, Satoshi, Wei, Gang, Tsukamoto, Taiji, Kuzumaki, Noboru, Takimoto, Masato

“…We have previously identified and cloned a human gene, D40, that is preferentially expressed in testis among normal organs, while it is widely expressed in…”
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Gelsolin gene therapy by retrovirus producer cells for human bladder cancer in nude mice by Tanaka, M, Sazawa, A, Shinohara, N, Kobayashi, Y, Fujioka, Y, Koyanagi, T, Kuzumaki, N

“…Gelsolin, a regulator of the actin cytoskeleton, has been shown previously to act as a tumor suppressor in vitro and in vivo when introduced into certain…”
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Involvement of Ras in the expression of glycolipid sulfotransferase in human renal cancer cells by Yabunaka, Norijuki, Honke, Koichi, Ishii, Atsushi, Ogiso, Yoshifumi, Kuzumaki, Noboru, Agishi, Yuko, Makita, Akira

“…Glycolipid sulfotransferase activity in a human renal cell carcinoma cell line, SMKT‐R3, is enhanced by epidermal growth factor (EGF); tyrosine kinase…”
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Differential Na+,K(+)-ATPase activity and cisplatin sensitivity between transformants induced by H-ras and those induced by K-ras by Shinohara, N, Ogiso, Y, Arai, T, Takami, S, Nonomura, K, Koyanagi, T, Kuzumaki, N

“…We examined the differential effects of the H-ras oncogene and the K-ras oncogene on cisplatin sensitivity in murine NIH/3T3 cells transfected with these…”
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Resistance of NIH3T3 cells to v-fes transformation induced by a dominant negative H-ras mutant by Ogiso, Y, Yokoyama, T, Watari, H, Shih, T Y, Kuzumaki, N

“…NIH3T3 cells carrying a dominant negative H-ras mutant 116Y acquired resistance to transformation by some PTK oncogenes, i.e., v-fes, v-abl, and v-fms, but…”
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Suppression of Pancreatic Cancer by the Dominant NegativerasMutant, N116Y by Shichinohe, Toshiaki, Senmaru, Naoto, Furuuchi, Keiji, Ogiso, Yoshifumi, Ishikura, Hiroshi, Yoshiki, Takashi, Takahashi, Toshiyuki, Kato, Hiroyuki, Kuzumaki, Noboru

“…N116Y, H-rasmutant, possesses dominant negative activity to Ras function. The aim of this study is to assess whether N116Y can inhibit the proliferation of…”
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siRNA gelsolin knockdown induces epithelial‐mesenchymal transition with a cadherin switch in human mammary epithelial cells by Tanaka, Hiroki, Shirkoohi, Reza, Nakagawa, Koji, Qiao, Hongjiang, Fujita, Hisakazu, Okada, Futoshi, Hamada, Jun‐ichi, Kuzumaki, Satoshi, Takimoto, Masato, Kuzumaki, Noboru

“…Epithelial‐mesenchymal transition (EMT) describes a process occurring during development and oncogenesis by which epithelial cells obtain fibroblast‐like…”
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Molecular analysis of the GCF gene identifies revisions to the cDNA and amino acid sequences by Takimoto, Masato, Mao, Peizhong, Wei, Gang, Yamazaki, Hitoshi, Miura, Tetsuya, Johnson, Alfred C., Kuzumaki, Noboru

“…GC factor (GCF) was reported as a transcriptional regulator that binds to a specific GC-rich sequence in the epidermal growth factor receptor (EGFR) gene…”
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Expression of granulocyte-macrophage colony-stimulating factor mRNA by inflammatory cells in the sarcoid lung by Itoh, A, Yamaguchi, E, Kuzumaki, N, Okazaki, N, Furuya, K, Abe, S, Kawakami, Y

“…T lymphocytes and alveolar macrophages accumulating in the lower respiratory tract of patients with pulmonary sarcoidosis are known to be activated to produce…”
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Inhibition of Alzheimer's amyloid-β peptide-induced reduction of mitochondrial membrane potential and neurotoxicity by gelsolin by Qiao, Hongjiang, Koya, Richard C., Nakagawa, Koji, Tanaka, Hiroki, Fujita, Hisakazu, Takimoto, Masato, Kuzumaki, Noboru

“…Amyloid-β (Aβ) peptides play a central role in the development of Alzheimer's disease. They are known to induce mitochondrial dysfunction and caspase…”
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Establishment and characterization of monoclonal antibody against androgen receptor by Demura, T, Kuzumaki, N, Oda, A, Fujita, H, Ishibashi, T, Koyanagi, T

“…Hybrid cell lines were prepared by the fusion of BALB/c myeloma NS-1 cells with the lymphocytes of BALB/c mice that were immunized with partially purified…”
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A monoclonal antibody against gamma-glutamyltransferase from human primary hepatoma: its use in enzyme-linked immunosorbent assay of sera of cancer patients by Taniguchi, N, House, S, Kuzumaki, N, Yokosawa, N, Yamagiwa, S, Iizuka, S, Makita, A, Sekiya, C

“…A monoclonal antibody, gamma-120, was raised against a highly purified gamma-glutamyltransferase (gamma GT) from human primary hepatoma. The antibody…”
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Frequent loss of gelsolin expression in non-small cell lung cancers of heavy smokers by DOSAKA-AKITA, H, HOMMURA, F, FUJITA, H, KINOSHITA, I, NISHI, M, MORIKAWA, T, KATOH, H, KAWAKAMI, Y, KUZUMAKI, N

“…Most lung and bladder cancers have been shown to be associated with smoking. We have previously demonstrated the frequent loss of gelsolin expression and its…”
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