Search Results - "Kuypers, Dirk J"

Therapeutic concentrations of calcineurin inhibitors do not deregulate glutathione redox balance in human renal proximal tubule cells by Ramazani, Yasaman, Knops, Noël, Berlingerio, Sante Princiero, Adebayo, Oyindamola Christiana, Lismont, Celien, Kuypers, Dirk J, Levtchenko, Elena, van den Heuvel, Lambert P, Fransen, Marc

“…The calcineurin inhibitors (CNI) cyclosporine A and tacrolimus comprise the basis of immunosuppressive regimes in all solid organ transplantation. However,…”
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Diagnosis and prevention of chronic kidney allograft loss by Nankivell, Brian J, Dr, Kuypers, Dirk RJ, Prof

“…Summary Kidney transplantation is the best possible treatment for many patients with end-stage renal failure, but progressive dysfunction and eventual…”
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Multidrug resistance protein 2 genetic polymorphisms influence mycophenolic acid exposure in renal allograft recipients by NAESENS, Maarten, KUYPERS, Dirk R. J, VERBEKE, Kristin, VANRENTERGHEM, Yves

“…Mycophenolic acid (MPA) is glucuronidated by uridine diphosphate-glucuronosyltransferases (UGTs) to its pharmacologically inactive 7-O-glucuronide metabolite…”
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Impact of POR28 on the Pharmacokinetics of Tacrolimus and Cyclosporine A in Renal Transplant Patients by ELENS, Laure, HESSELINK, Dennis A, VAN SCHAIK, Ron H. N, BOUAMAR, Rachida, BUDDE, Klemens, DE FIJTER, Johannes W, DE MEYER, Martine, MOURAD, Michel, KUYPERS, Dirk R. J, HAUFROID, Vincent, VAN GELDER, Teun

“…The P450 oxidoreductase (POR)*28 variant allele has been associated with altered cytochrome P450 3A enzyme activities. Both CYP3A5 and CYP3A4 are involved in…”
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Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-Risk Kidney Transplant Recipients: A Randomized Clinical Trial by Limaye, Ajit P, Budde, Klemens, Humar, Atul, Vincenti, Flavio, Kuypers, Dirk R. J, Carroll, Robert P, Stauffer, Nicole, Murata, Yoshihiko, Strizki, Julie M, Teal, Valerie L, Gilbert, Christopher L, Haber, Barbara A

“…IMPORTANCE: Valganciclovir for 200 days is standard care for cytomegalovirus (CMV) prophylaxis in high-risk CMV-seronegative kidney transplant recipients who…”
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Calcineurin Inhibitor Nephrotoxicity by Naesens, Maarten, Kuypers, Dirk R J, Sarwal, Minnie

“…The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in the field of transplantation, with excellent short-term outcome…”
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Clinical determinants of calcineurin inhibitor disposition: a mechanistic review by Vanhove, Thomas, Annaert, Pieter, Kuypers, Dirk R. J.

“…The calcineurin inhibitors (CNIs) tacrolimus and cyclosporine are widely used immunosuppressive drugs characterized by high pharmacokinetic and pharmacodynamic…”
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Immunotherapy in Elderly Transplant Recipients: A Guide to Clinically Significant Drug Interactions by Kuypers, Dirk R. J.

“…Currently, >50% of candidates for solid organ transplantation in Europe and the US are aged >50 years while approximately 15% of potential recipients are aged…”
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The impact of renal allograft function on exposure and elimination of mycophenolic acid (MPA) and its metabolite MPA 7-O-glucuronide by NAESENS, Maarten, DE LOOR, Henriette, VANRENTERGHEM, Yves, KUYPERS, Dirk R. J

“…Previous studies have shown that total-body clearance of mycophenolic acid (MPA) is increased and total MPA exposure decreased in renal allograft recipients…”
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The histology of kidney transplant failure: a long-term follow-up study by Naesens, Maarten, Kuypers, Dirk R J, De Vusser, Katrien, Evenepoel, Pieter, Claes, Kathleen, Bammens, Bert, Meijers, Björn, Sprangers, Ben, Pirenne, Jacques, Monbaliu, Diethard, Jochmans, Ina, Lerut, Evelyne

“…The relative impact on renal allograft outcome of specific histological diagnoses versus nonspecific chronic histological damage remains unclear. All 1,197…”
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Management of polyomavirus-associated nephropathy in renal transplant recipients by Kuypers, Dirk R. J.

“…Polyomavirus-associated nephropathy (PVAN) is an important infectious complication after renal transplantation, affecting 1–10% of recipients and causing graft…”
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Donor Age and Renal P-Glycoprotein Expression Associate with Chronic Histological Damage in Renal Allografts by NAESENS, Maarten, LERUT, Evelyne, DE JONGE, Hylke, VAN DAMME, Boudewijn, VANRENTERGHEM, Yves, KUYPERS, Dirk R. J

“…The contributions of donor kidney quality (partially determined by donor age), allograft rejection, and calcineurin inhibitor nephrotoxicity on the progression…”
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Atypical Hemolytic Uremic Syndrome Occurring After Receipt of mRNA-1273 COVID-19 Vaccine Booster: A Case Report by Claes, Kathleen J., Geerts, Inge, Lemahieu, Wim, Wilmer, Alexander, Kuypers, Dirk R.J., Koshy, Priyanka, Ombelet, Sara

“…Atypical hemolytic uremic syndrome (aHUS) is a subtype of thrombotic microangiopathy (TMA) characterized by a dysregulation of the alternative complement…”
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A Machine Learning-Driven Virtual Biopsy System For Kidney Transplant Patients by Yoo, Daniel, Divard, Gillian, Raynaud, Marc, Cohen, Aaron, Mone, Tom D., Rosenthal, John Thomas, Bentall, Andrew J., Stegall, Mark D., Naesens, Maarten, Zhang, Huanxi, Wang, Changxi, Gueguen, Juliette, Kamar, Nassim, Bouquegneau, Antoine, Batal, Ibrahim, Coley, Shana M., Gill, John S., Oppenheimer, Federico, De Sousa-Amorim, Erika, Kuypers, Dirk R. J., Durrbach, Antoine, Seron, Daniel, Rabant, Marion, Van Huyen, Jean-Paul Duong, Campbell, Patricia, Shojai, Soroush, Mengel, Michael, Bestard, Oriol, Basic-Jukic, Nikolina, Jurić, Ivana, Boor, Peter, Cornell, Lynn D., Alexander, Mariam P., Toby Coates, P., Legendre, Christophe, Reese, Peter P., Lefaucheur, Carmen, Aubert, Olivier, Loupy, Alexandre

“…In kidney transplantation, day-zero biopsies are used to assess organ quality and discriminate between donor-inherited lesions and those acquired…”
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Cutaneous phaeohyphomycosis in renal allograft recipients: report of 2 cases and review of the literature by Vermeire, Sylvie E.M, de Jonge, Hylke, Lagrou, Katrien, Kuypers, Dirk R.J

“…Abstract Dematiaceous molds are increasingly recognized as important human pathogens. We report 2 cases of cutaneous phaeohyphomycosis in renal allograft…”
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Progressive decline in tacrolimus clearance after renal transplantation is partially explained by decreasing CYP3A4 activity and increasing haematocrit by Jonge, Hylke, Vanhove, Thomas, Loor, Henriëtte, Verbeke, Kristin, Kuypers, Dirk R. J.

“…Aims The long‐term disposition of tacrolimus following kidney transplantation is characterized by a gradual decrease in dose requirements and increase in…”
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Relationship between In Vivo CYP3A4 Activity, CYP3A5 Genotype, and Systemic Tacrolimus Metabolite/Parent Drug Ratio in Renal Transplant Recipients and Healthy Volunteers by Vanhove, Thomas, de Jonge, Hylke, de Loor, Henriëtte, Oorts, Marlies, de Hoon, Jan, Pohanka, Anton, Annaert, Pieter, Kuypers, Dirk R J

“…CYP3A5 genotype is a major determinant of tacrolimus clearance, and has been shown to affect systemic tacrolimus metabolite/parent ratios in healthy…”
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Tacrolimus induces a pro-fibrotic response in donor-derived human proximal tubule cells dependent on common variants of the CYP3A5 and ABCB1 genes by Knops, Noël, Ramazani, Yasaman, De Loor, Henriëtte, Goldschmeding, Roel, Nguyen, Tri Q, van den Heuvel, Lambert P, Levtchenko, Elena, Kuypers, Dirk J

“…ABSTRACT Background Common genetic variants of the enzymes and efflux pump involved in tacrolimus disposition have been associated with calcineurin inhibitor…”
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New Insights Into the Pharmacokinetics and Pharmacodynamics of the Calcineurin Inhibitors and Mycophenolic Acid: Possible Consequences for Therapeutic Drug Monitoring in Solid Organ Transplantation by DE JONG, Hylke, NAESENS, Maarten, KUYPERS, Dirk R. J

“…Although therapeutic drug monitoring (TDM) of immunosuppressive drugs has been an integral part of routine clinical practice in solid organ transplantation for…”
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The impact of uridine diphosphate–glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single‐nucleotide polymorphisms T—275A and C—2152T on early mycophenolic acid dose‐interval exposure in de novo renal allograft recipients by Kuypers, Dirk R. J., Naesens, Maarten, Vermeire, Severine, Vanrenterghem, Yves

“…Background Mycophenolic acid (MPA), an effective immunosuppressive drug used in renal transplantation, is extensively glucuronidated by several uridine…”
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