Search Results - "Kuwayama, Kenji"

Development of High-resolution Methods for the Analysis of Drug Distribution in Biological Tissue Samples and Their Applications by Kuwayama, Kenji

“…The abuse of drugs has become a serious social problem worldwide. Amphetamine-type stimulants such as methamphetamine are recreationally abused and can cause…”
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Enantioselective determination of (R)-zopiclone and (S)-zopiclone (eszopiclone) in human hair by micropulverized extraction and chiral liquid chromatography/high resolution mass spectrometry by Miyaguchi, Hajime, Kuwayama, Kenji

“…•Micropulverized extraction was utilized for 5mg of hair sample to minimize the degradation of zopiclone and for rapid and facile operation.•An excellent…”
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Metabolism of Butyrylfentanyl in Fresh Human Hepatocytes: Chemical Synthesis of Authentic Metabolite Standards for Definitive Identification by Kanamori, Tatsuyuki, Iwata, Yuko Togawa, Segawa, Hiroki, Yamamuro, Tadashi, Kuwayama, Kenji, Tsujikawa, Kenji, Inoue, Hiroyuki

“…The metabolism of butyrylfentanyl, a new designer drug, was investigated using fresh human hepatocytes isolated from a liver-humanized mouse model. In the…”
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Metabolism of Fentanyl and Acetylfentanyl in Human-Induced Pluripotent Stem Cell-Derived Hepatocytes by Kanamori, Tatsuyuki, Iwata, Yuko Togawa, Segawa, Hiroki, Yamamuro, Tadashi, Kuwayama, Kenji, Tsujikawa, Kenji, Inoue, Hiroyuki

“…To evaluate the capability of human-induced pluripotent stem cell-derived hepatocytes (h-iPS-HEP) in drug metabolism, the profiles of the metabolites of…”
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Micro-segmental hair analysis: detailed procedures and applications in forensic toxicology by Kuwayama, Kenji, Miyaguchi, Hajime, Kanamori, Tatsuyuki, Tsujikawa, Kenji, Yamamuro, Tadashi, Segawa, Hiroki, Okada, Yuki, Iwata, Yuko T.

“…Purpose Since the 1980s, the detection sensitivity of mass spectrometers has increased by improving the analysis of drugs in hair. Accordingly, the number of…”
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Possibility of drug-distribution measurement in the hair of drowned bodies: evaluation of drug stability in water-soaked hair using micro-segmental analysis by Kuwayama, Kenji, Miyaguchi, Hajime, Kanamori, Tatsuyuki, Tsujikawa, Kenji, Yamamuro, Tadashi, Segawa, Hiroki, Okada, Yuki, Iwata, Yuko T.

“…In postmortem examinations, the drug analysis of hair is effective for revealing drug-use history. Additionally, a method to estimate the day of death using…”
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Three-step drug extraction from a single sub-millimeter segment of hair and nail to determine the exact day of drug intake by Kuwayama, Kenji, Miyaguchi, Hajime, Iwata, Yuko T., Kanamori, Tatsuyuki, Tsujikawa, Kenji, Yamamuro, Tadashi, Segawa, Hiroki, Inoue, Hiroyuki

“…Hair and nails are often used to prove drug intake over several months. However, it is impossible to determine the day of drug intake by conventional segmental…”
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Measurement of three-dimensional distributions of drugs in nails using liquid chromatography/tandem mass spectrometry after micro-segmentation to elucidate drug uptake routes by Kuwayama, Kenji, Miyaguchi, Hajime, Kanamori, Tatsuyuki, Tsujikawa, Kenji, Yamamuro, Tadashi, Segawa, Hiroki, Okada, Yuki, Iwata, Yuko T.

“…Ingested drugs can be taken up into nails and hairs from the bloodstream and these drugs can be stably retained over several months or more. Free edges of…”
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Evaluation of Agonistic Activity of Fluorinated and Nonfluorinated Fentanyl Analogs on μ-Opioid Receptor Using a Cell-Based Assay System by Kanamori, Tatsuyuki, Okada, Yuki, Segawa, Hiroki, Yamamuro, Tadashi, Kuwayama, Kenji, Tsujikawa, Kenji, Iwata, Yuko Togawa

“…The agonistic activity of fluorinated and nonfluorinated fentanyl analogs on µ-opioid receptor was investigated using a cell-based assay system. Based on the…”
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Short-term stability of a small amount of neat Δ9-tetrahydrocannabinol by Tsujikawa, Kenji, Okada, Yuki, Segawa, Hiroki, Yamamuro, Tadashi, Kuwayama, Kenji, Kanamori, Tatsuyuki, Iwata, Yuko. T.

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Use of hepatocytes isolated from a liver-humanized mouse for studies on the metabolism of drugs: application to the metabolism of fentanyl and acetylfentanyl by Kanamori, Tatsuyuki, Togawa-Iwata, Yuko, Segawa, Hiroki, Yamamuro, Tadashi, Kuwayama, Kenji, Tsujikawa, Kenji, Inoue, Hiroyuki

“…Purpose The usefulness of hepatocytes isolated from a liver-humanized mouse (PXB-cells) as a model in vitro system for the prediction of the in vivo metabolism…”
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Rapid identification of drug-type and fiber-type cannabis by allele specific duplex PCR by Yamamuro, Tadashi, Segawa, Hiroki, Kuwayama, Kenji, Tsujikawa, Kenji, Kanamori, Tatsuyuki, Iwata, Yuko T.

“…•We developed a new method to rapidly distinguish drug-type from fiber-type cannabis.•Active THCAS and CBDAS are characteristic of drug-type and fiber-type,…”
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Thin-layer chromatography on silver nitrate-impregnated silica gel for analysis of homemade tetrahydrocannabinol mixtures by Tsujikawa, Kenji, Okada, Yuki, Segawa, Hiroki, Yamamuro, Tadashi, Kuwayama, Kenji, Kanamori, Tatsuyuki, Iwata, Yuko T.

“…Purpose Various forms of cannabidiol (CBD)-containing products are sold in Japan. CBD is easily converted to mixtures of ∆ 9 -tetrahydrocannabinol (∆ 9 -THC)…”
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Distribution profiles of diphenhydramine and lidocaine in scalp, axillary, and pubic hairs measured by micro-segmental hair analysis: good indicator for discrimination between administration and external contamination of the drugs by Kuwayama, Kenji, Miyaguchi, Hajime, Kanamori, Tatsuyuki, Tsujikawa, Kenji, Yamamuro, Tadashi, Segawa, Hiroki, Okada, Yuki, Iwata, Yuko T.

“…Purpose Drug distribution in scalp hair can provide historical information about drug use, such as the date and frequency of drug ingestion. We previously…”
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Evaluation of applicability of micro-segmental analysis to hair treated with heat and haircare products by Kuwayama, Kenji, Miyaguchi, Hajime, Kanamori, Tatsuyuki, Tsujikawa, Kenji, Yamamuro, Tadashi, Segawa, Hiroki, Okada, Yuki, Iwata, Yuko T.

“…Purpose Micro-segmental analysis (MSA), which enables the measurement of detailed drug distributions in hair by segmenting a single hair strand at 0.4 mm…”
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Development of the “selective concentration” analytical method for drug-containing hair regions based on micro-segmental analysis to identify a trace amount of drug in hair: hair analysis following single-dose ingestion of midazolam by Kuwayama, Kenji, Miyaguchi, Hajime, Kanamori, Tatsuyuki, Tsujikawa, Kenji, Yamamuro, Tadashi, Segawa, Hiroki, Okada, Yuki, Iwata, Yuko T.

“…Purpose Hair can be the only available specimen to prove drug-facilitated crimes (DFCs). However, it is difficult to identify drugs abused in DFCs,…”
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Characterization and Differentiation of Geometric Isomers of 3‐methylfentanyl Analogs by Gas Chromatography/Mass Spectrometry, Liquid Chromatography/Mass Spectrometry, and Nuclear Magnetic Resonance Spectroscopy by Kanamori, Tatsuyuki, Iwata, Yuko T., Segawa, Hiroki, Yamamuro, Tadashi, Kuwayama, Kenji, Tsujikawa, Kenji, Inoue, Hiroyuki

“…The cis and trans isomers of 3‐methylfentanyl and its three analogs were chemically synthesized, and these compounds were characterized and differentiated by…”
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The use of a sulfonated capillary on chiral capillary electrophoresis/mass spectrometry of amphetamine-type stimulants for methamphetamine impurity profiling by Mikuma, Toshiyasu, Iwata, Yuko T, Miyaguchi, Hajime, Kuwayama, Kenji, Tsujikawa, Kenji, Kanamori, Tatsuyuki, Inoue, Hiroyuki

“…Highlights • Chiral CE/MS/MS using a chemically modified capillary was developed. • 8 amphetamine-type stimulants were well resolved within 60 min. • The…”
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Strong evidence of drug-facilitated crimes by hair analysis using LC–MS/MS after micro-segmentation by Kuwayama, Kenji, Miyaguchi, Hajime, Iwata, Yuko T., Kanamori, Tatsuyuki, Tsujikawa, Kenji, Yamamuro, Tadashi, Segawa, Hiroki, Inoue, Hiroyuki

“…Purpose Hair analysis can provide effective information to prove drug-facilitated crimes (DFCs). Herein, an analytical procedure for obtaining evidence of DFCs…”
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Detection and confirmation of the ring-opened carboxylic acid metabolite of a new synthetic opioid furanylfentanyl by Kanamori, Tatsuyuki, Okada, Yuki, Segawa, Hiroki, Yamamuro, Tadashi, Kuwayama, Kenji, Tsujikawa, Kenji, Togawa-Iwata, Yuko

“…Purpose Recently, the opioid epidemic has become a serious problem, particularly in North America and Europe. The aim of this study was to clarifyQuery the…”
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