Search Results - "Kuwaki, Tomoaki"

Hepatocyte growth factor accelerates thrombopoiesis in transgenic mice by Kosone, Takashi, Takagi, Hitoshi, Horiguchi, Norio, Toyoda, Mitsuo, Sohara, Naondo, Kakizaki, Satoru, Sato, Ken, Nishiyama, Uichi, Kuwaki, Tomoaki, Mori, Masatomo

“…Hepatocyte growth factor (HGF) is one of the potent growth factors for liver regeneration and has a strong effect on epithelial and nonepithelial cells. As one…”
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Lineage-specific expression of granulocyte colony-stimulating factor and thrombopoietin receptors in terminally differentiated hematopoietic cells by Kuwaki, Tomoaki, Oda, Atsushi, Yuki, Chizuru, Suzuki, Hidenori, Murasaki, Kagari, Fujita, Hiroyoshi, Miyazaki, Hiroshi, Ikeda, Yasuo

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Granulocyte colony-stimulating factor administration modulates the surface expression of effector cell molecules on human monocytes by Ohsaka, A, Saionji, K, Kuwaki, T, Takeshima, T, Igari, J

“…Granulocyte colony-stimulating factor (G-CSF) has been shown to stimulate human neutrophil functions, both in vitro and in vivo. We examined the effects of…”
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Platelets exposed to elevated levels of endogenous thrombopoietin in vivo have a reduced response to megakaryocyte growth and development factor in vitro by Nishiyama, U, Morita, H, Torii, Y, Kuwaki, T, Shimizu, E, Akahori, H, Kato, T, Miyazaki, H

“…Thrombopoietin (TPO), or megakaryocyte growth and development factor (MGDF), has been shown to potentiate the sensitivity of normal human platelets to various…”
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Neutralization of Biological Activity and Inhibition of Receptor Binding by Antibodies Against Human Thrombopoietin by Tahara, Tomoyuki, Kuwaki, Tomoaki, Matsumoto, Atsushi, Morita, Haruhiko, Watarai, Hiroshi, Inagaki, Yoshimasa, Ohashi, Hideya, Ogami, Kinya, Miyazaki, Hiroshi, Kato, Takashi

“…Thrombopoietin (TPO) is a recently isolated cytokine that primarily regulates megakaryocytopoiesis and thrombopoiesis. We recently reported the development of…”
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Successful treatment of pustulosis palmaris et plantaris with granulocyte colony stimulating factor in a patient with hereditary neutropenia by Hino, M, Yamane, T, Kuwaki, T, Kono, T, Kitagawa, S, Tatsumi, N

“…A 26-year-old female with hereditary neutropenia had Pustulosis Palmaris et Plantaris. Drug administration did not improve her symptoms. Following…”
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A potential therapeutic role for small nonpeptidyl compounds that mimic human granulocyte colony-stimulating factor by Kusano, Kouji, Ebara, Shinji, Tachibana, Koichi, Nishimura, Tadahiro, Sato, Susumu, Kuwaki, Tomoaki, Taniyama, Tadayoshi

“…Granulocyte colony-stimulating factor (G-CSF) stimulates the proliferation of bone marrow granulocytic progenitor cells and promotes their differentiation into…”
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Synergistic Effects of Granulocyte-colony stimulating factor and Erythropoietin on Left Ventricular Systolic Function in Rat Myocardial Infarction by Sunagawa, Yoichi, Morimoto, Tatsuya, Takaya, Tomohide, Kuwaki, Tomoaki, Yanagi, Shigeki, Marui, Akira, Ikeda, Tadashi, Fujita, Masatoshi, Kita, Toru, Hawagawa, Koji

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Effects of T-Helper 2-Type Cytokines, Interleukin-3 (IL-3), IL-4, IL-5, and IL-6 on the Survival of Cultured Human Mast Cells by Yanagida, Makoto, Fukamachi, Hiromi, Ohgami, Kinya, Kuwaki, Tomoaki, Ishii, Hiromi, Uzumaki, Hiroya, Amano, Kenji, Tokiwa, Tomonobu, Mitsui, Hideki, Saito, Hirohisa, Iikura, Yoji, Ishizaka, Teruko, Nakahata, Tatsutoshi

“…Although stem cell factor (SCF) has been identified as a critical cytokine for the development of human mast cells from their progenitors, the effects of other…”
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Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin by Kitamura, T, Tange, T, Terasawa, T, Chiba, S, Kuwaki, T, Miyagawa, K, Piao, Y F, Miyazono, K, Urabe, A, Takaku, F

“…We have established a novel cell line, designated as TF-1, from a patient with erythroleukemia, which showed complete growth dependency on…”
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Determination of Thrombopoietin‐Derived Peptides Recognized by Both Cellular and Humoral Immunities in Healthy Donors and Patients with Thrombocytopenia by Takedatsu, Hiroko, Yoshimoto, Kohji, Okamura, Takashi, Miyazaki, Hiroshi, Kuwaki, Tomoaki, Sata, Michio, Itoh, Kyogo

“…Thrombopoietin (TPO) is a cytokine that promotes megakaryocytopoiesis and thrombopoiesis and is considered a drug suitable for patients with thrombocytopenia…”
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Autoantibodies neutralizing thrombopoietin in a patient with amegakaryocytic thrombocytopenic purpura by Shiozaki, H, Miyawaki, S, Kuwaki, T, Hagiwara, T, Kato, T, Miyazaki, H

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Antineoplastic effect of a single oral dose of the novel Flt3 inhibitor KRN383 on xenografted human leukemic cells harboring Flt3-activating mutations by Nishiyama, Uichi, Yoshino, Tetsuya, Ozai, Masako, Yoshioka, Rieko, Fujisawa, Motoko, Ogasawara, Yuko, Kitahori, Miyuki, Yoshioka, Eiji, Kubo, Kazuo, Komeno, Yukiko, Kurokawa, Mineo, Ogawa, Seishi, Chiba, Shigeru, Osawa, Tatsushi, Kuwaki, Tomoaki, Hirai, Hisamaru, Miwa, Atsushi

“…Activating mutations of Fms-like tyrosine kinase 3 (Flt3) are the most common genetic abnormalities found in acute myeloid leukemia (AML) and represent…”
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A Continuous Low-dose-G-CSF Therapy Improves the Survival and Left Ventricular Systolic Function in Cardiomyopathic Hamsters with End-stage Heart Failure by Kawamura, Teruhisa, Miyamoto, Shoichi, Ono, Koh, Morimoto, Tatsuya, Abe, Yukiko, Kano, Mayumi, Kuwaki, Tomoaki, Nomura, Hideaki, Hasegawa, Koji

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Corrigendum to “Antineoplastic effect of a single oral dose of the novel Flt3 inhibitor KRN383 on xenografted human leukemic cells harboring Flt3-activating mutations” [Leuk. Res. 30 (2006) 1541–1546] by Nishiyama, Uichi, Yoshino, Tetsuya, Ozai, Masako, Yoshioka, Rieko, Fujisawa, Motoko, Ogasawara, Yuko, Kitahori, Miyuki, Yoshioka, Eiji, Kubo, Kazuo, Komeno, Yukiko, Kurokawa, Mineo, Ogawa, Seishi, Chiba, Shigeru, Osawa, Tatsushi, Kuwaki, Tomoaki, Hirai, Hisamaru, Miwa, Atsushi

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Autoantibodies neutralizing thrombopoietin in a patient with a megakaryocytic thrombocytopenic purpura by Kuwaki, Tomoaki, Hagiwara, Tetsuya, Kato, Takashi, Miyazaki, Hiroshi

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Ki23819 (KRN383•HCl) Inhibits Kinase Activity of Wild Type and Mutant FLT3 Receptor Tyrosine Kinase In Vitro by Komeno, Yukiko, Kurokawa, Mineo, Imai, Yoichi, Takeshita, Masataka, Matsumura, Tomoko, Kubo, Kazuo, Yoshino, Tetsuya, Nishiyama, Uichi, Kuwaki, Tomoaki, Kubo, Kinya, Osawa, Tatsushi, Ogawa, Seishi, Chiba, Shigeru, Miwa, Atsushi, Hirai, Hisamaru

“…[Background] FLT3 is a class III receptor tyrosine kinase which is widely expressed on hematopoietic stem/progenitor cells. Two types of constitutively active…”
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Single Oral Administration of KRN383, a Novel Flt3 Inhibitor, Induces Eradication of the Xenograft Tumor Harboring Flt3 Mutation in Mice by Nishiyama, Uichi, Ozai, Masako, Yoshioka, Rieko, Yoshino, Tetsuya, Ogasawara, Yuko, Kitahori, Miyuki, Yoshioka, Eiji, Kubo, Kazuo, Komeno, Yukiko, Kurokawa, Mineo, Ogawa, Seishi, Chiba, Shigeru, Osawa, Tatsushi, Kuwaki, Tomoaki, Hirai, Hisamaru, Miwa, Atsushi

“…Constitutively activating mutations of the Flt3 receptor tyrosine kinase including internal tandem duplication (ITD) mutations are the most common genetic…”
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Pegylated recombinant human megakaryocyte growth and development factor suppresses the development of megakaryoblastic leukemia in mice by Shibuya, Kazunori, Kuwaki, Tomoaki, Akahori, Hiromichi, Kato, Takashi, Miyazaki, Hiroshi

“…We examined the effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on the development of L-8057, a murine…”
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Marked improvement of thrombocytopenia in a murine model of idiopathic thrombocytopenic purpura by pegylated recombinant human megakaryocyte growth and development factor by Shibuya, Kazunori, Kuwaki, Tomoaki, Tahara, Emiko, Yuki, Chizuru, Akahori, Hiromichi, Kato, Takashi, Miyazaki, Hiroshi

“…We examined the stimulatory effect of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet production in male (NZW…”
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