Search Results - "Kuwahara, Fumitaka"

Diastolic Dysfunction in Hypertensive Hearts: Roles of Perivascular Inflammation and Reactive Myocardial Fibrosis by Kai, Hisashi, Kuwahara, Fumitaka, Tokuda, Keisuke, Imaizumi, Tsutomu

“…There is increasing evidence that myocardial fibrosis plays a role in the pathogenesis of diastolic dysfunction in hypertensive heart disease. However, it has…”
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Pressure-Independent Effects of Angiotensin II on Hypertensive Myocardial Fibrosis by Tokuda, Keisuke, Kai, Hisashi, Kuwahara, Fumitaka, Yasukawa, Hideo, Tahara, Nobuhiro, Kudo, Hiroshi, Takemiya, Kiyoko, Koga, Mitsuhisa, Yamamoto, Tomoka, Imaizumi, Tsutomu

“…ABSTRACT—Angiotensin II (Ang II) is implicated in the proinflammatory process in various disease situations. Thus, we sought to determine the role of Ang II in…”
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Pressure Overload-Induced Transient Oxidative Stress Mediates Perivascular Inflammation and Cardiac Fibrosis through Angiotensin II by KAI, Hisashi, MORI, Takahiro, TOKUDA, Keisuke, TAKAYAMA, Narimasa, TAHARA, Nobuhiro, TAKEMIYA, Kiyoko, KUDO, Hiroshi, SUGI, Yusuke, FUKUI, Daisuke, YASUKAWA, Hideo, KUWAHARA, Fumitaka, IMAIZUMI, Tsutomu

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Roles of Intercellular Adhesion Molecule-1 in Hypertensive Cardiac Remodeling by Kuwahara, Fumitaka, Kai, Hisashi, Tokuda, Keisuke, Niiyama, Hiroshi, Tahara, Nobuhiro, Kusaba, Ken, Takemiya, Kiyoko, Jalalidin, Ali, Koga, Mitsuhisa, Nagata, Tsuyoshi, Shibata, Rei, Imaizumi, Tsutomu

“…ABSTRACT—Recently, we have shown that in rats with a suprarenal abdominal aortic constriction (AC), pressure overload induces early perivascular…”
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Long-Term Treatment with Valsartan Improved Cyclic Variation of the Myocardial Integral Backscatter Signal and Diastolic Dysfunction in Hypertensive Patients: The Echocardiographic Assessment by Mizuta, Yoshihiko, Kai, Hisashi, Mizoguchi, Minori, Osada, Katsunori, Tahara, Nobuhiro, Nakaura, Hiroyuki, Kuwahara, Fumitaka, Imaizumi, Tsutomu

“…Myocardial fibrosis is the major determinant of diastolic property of the left ventricle (LV). Experimental and clinical studies have suggested that…”
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Rho-Kinase Inhibition Reduces Neointima Formation after Vascular Injury by Enhancing Bax Expression and Apoptosis by Shibata, Rei, Kai, Hisashi, Seki, Yukihiko, Kusaba, Ken, Takemiya, Kiyoko, Koga, Mitsuhisa, Jalalidin, Ali, Tokuda, Keisuke, Tahara, Nobuhiro, Niiyama, Hiroshi, Nagata, Tsuyoshi, Kuwahara, Fumitaka, Imaizumi, Tsutomu

“…Recently, we have shown that a specific Rho-kinase inhibitor, Y27632 (R-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)- cyclohexanecarboxamide), prevents neointima…”
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Coexistence of Hypercholesterolemia and Hypertension Impairs Adventitial Vascularization by Kai, Hisashi, Kuwahara, Fumitaka, Tokuda, Keisuke, Shibata, Rei, Kusaba, Ken, Niiyama, Hiroshi, Tahara, Nobuhiro, Nagata, Tsuyoshi, Imaizumi, Tsutomu

“…We have shown that adventitial vasa vasorum (AVV) formation is enhanced in hypertensive rat aorta to compensate hypoxia in the thickened media and that…”
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Transforming growth factor-β function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats by KUWAHARA, Fumitaka, KAI, Hisashi, TOKUDA, Keisuke, KAI, Mamiko, TAKESHITA, Akira, EGASHIRA, Kensuke, IMAIZUMI, Tsutomu

“…Excessive myocardial fibrosis impairs cardiac function in hypertensive hearts. Roles of transforming growth factor (TGF)-beta in myocardial remodeling and…”
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Hypertensive Myocardial Fibrosis and Diastolic Dysfunction: Another Model of Inflammation? by Kuwahara, Fumitaka, Kai, Hisashi, Tokuda, Keisuke, Takeya, Motohiro, Takeshita, Akira, Egashira, Kensuke, Imaizumi, Tsutomu

“…ABSTRACT—Excessive myocardial fibrosis deteriorates diastolic function in hypertensive hearts. Involvement of macrophages is suggested in fibrotic process in…”
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Peripheral blood levels of matrix metalloproteases-2 and -9 are elevated in patients with acute coronary syndromes by Kai, Hisashi, Ikeda, Hisao, Yasukawa, Hideo, Kai, Mamiko, Seki, Yukihiko, Kuwahara, Fumitaka, Ueno, Takafumi, Sugi, Kenzo, Imaizumi, Tsutomu

“…Objectives. This study was sought to investigate whether peripheral blood levels of matrix metalloproteases (MMPs) are affected in patients with acute coronary…”
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Pressure overload-induced transient oxidative stress mediates perivascular inflammation and cardiac fibrosis through angiotensin II by Kai, Hisashi, Mori, Takahiro, Tokuda, Keisuke, Takayama, Narimasa, Tahara, Nobuhiro, Takemiya, Kiyoko, Kudo, Hiroshi, Sugi, Yusuke, Fukui, Daisuke, Yasukawa, Hideo, Kuwahara, Fumitaka, Imaizumi, Tsutomu

“…Oxidative stress is implicated in the pathogenesis of various cardiovascular diseases. We have shown that in Wistar rats with a suprarenal aortic constriction…”
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Hypoxia-Inducible Factor-1α/Vascular Endothelial Growth Factor Pathway for Adventitial Vasa Vasorum Formation in Hypertensive Rat Aorta by Kuwahara, Fumitaka, Kai, Hisashi, Tokuda, Keisuke, Shibata, Rei, Kusaba, Ken, Tahara, Nobuhiro, Niiyama, Hiroshi, Nagata, Tsuyoshi, Imaizumi, Tsutomu

“…The roles of adventitial vasa vasorum have been highlighted in vascular wall homeostasis. Vascular endothelial growth factor (VEGF) is a potent angiogenic…”
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Expression of Proto-oncogenes and Gene Mutation of Sarcomeric Proteins in Patients With Hypertrophic Cardiomyopathy by Kai, Hisashi, Muraishi, Akihiko, Sugiu, Yuji, Nishi, Hirohumi, Seki, Yukihiko, Kuwahara, Fumitaka, Kimura, Akinori, Kato, Hirohisa, Imaizumi, Tsutomu

“…Several mutations of cardiac beta-myosin heavy chain (beta-MHC) gene were reported in patients with hypertrophic cardiomyopathy (HCM). Involvement of…”
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Sub-Depressor Dose of Angiotensin Type-1 Receptor Blocker Inhibits Transforming Growth Factor-β-Mediated Perivascular Fibrosis in Hypertensive Rat Hearts by Tokuda, Keisuke, Kai, Hisashi, Kuwahara, Fumitaka, Imaizumi, Tsutomu

“…Recently, we have shown that pressure overload transiently induces transforming growth factor-β-mediated fibroblast proliferation and reactive myocardial…”
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Transforming growth factor-(beta) function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats by Kuwahara, Fumitaka, Kai, Hisashi, Tokuda, Keisuke, Mamiko Kai

“…BACKGROUND: Excessive myocardial fibrosis impairs cardiac function in hypertensive hearts. Roles of transforming growth factor (TGF)-beta in myocardial…”
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Hypoxia-inducible factor-1(alpha)/vascular endothelial growth factor pathway for adventitial vasa vasorum formation in hypertensive rat aorta by Kuwahara, Fumitaka, Kai, Hisashi, Tokuda, Keisuke, Shibata, Rei

“…The roles of adventitial vasa vasorum have been highlighted in vascular wall homeostasis. Vascular endothelial growth factor (VEGF) is a potent angiogenic…”
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Hypertensive myocardial fibrosis and diastolic dysfunction: Another model of inflammation? Commentary by WEBER, Karl T, KUWAHARA, Fumitaka, KAI, Hisashi, TOKUDA, Keisuke, TAKEYA, Motohiro, TAKESHITA, Akira, EGASHIRA, Kensuke, IMAIZUMI, Tsutomu

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Inhibition of TGF-β prevents cardiac fibrosis and diastolic dysfunction in hypertensive rats by Kuwahara, Fumitaka, Kai, Hisashi, Nagata, Tsuyoshi, Shibata, Rei, Niiyama, Hiroshi, Imaizumi, Tsutomu

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Hypoxia-inducible factor-1alpha/vascular endothelial growth factor pathway for adventitial vasa vasorum formation in hypertensive rat aorta by Kuwahara, Fumitaka, Kai, Hisashi, Tokuda, Keisuke, Shibata, Rei, Kusaba, Ken, Tahara, Nobuhiro, Niiyama, Hiroshi, Nagata, Tsuyoshi, Imaizumi, Tsutomu

“…The roles of adventitial vasa vasorum have been highlighted in vascular wall homeostasis. Vascular endothelial growth factor (VEGF) is a potent angiogenic…”
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