Search Results - "Kuwabara, Rei"

Acetate and Butyrate Improve β-cell Metabolism and Mitochondrial Respiration under Oxidative Stress by Hu, Shuxian, Kuwabara, Rei, de Haan, Bart J, Smink, Alexandra M, de Vos, Paul

“…Islet dysfunction mediated by oxidative and mitochondrial stress contributes to the development of type 1 and 2 diabetes. Acetate and butyrate, produced by gut…”
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Bioabsorbable device to prepare subcutaneous pockets for islet transplantation by Kuwabara, Rei, Iwata, Hiroo

“…Small invasive transplantation of islets and long maintenance of the islet graft without immunosuppression has been studied for the treatment of type 1…”
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Interaction between cells and poly(ethylene glycol)-lipid conjugates by Itagaki, Toru, Arima, Yusuke, Kuwabara, Rei, Kitamura, Narufumi, Iwata, Hiroo

“…[Display omitted] •Interaction of PEG-lipids carrying different lipid parts with cells were examined.•Cell membrane was modified with PEG-lipids within 15min…”
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Coaggregates of Regulatory T Cells and Islet Cells Allow Long-term Graft Survival in Liver Without Immunosuppression by Takemoto, Naohiro, Konagaya, Shuhei, Kuwabara, Rei, Iwata, Hiroo

“…BACKGROUNDTransplantation of islets of Langerhans (islets) has been investigated in the clinic to treat patients with insulin-dependent diabetes mellitus…”
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Low methyl-esterified pectin protects pancreatic β-cells against diabetes-induced oxidative and inflammatory stress via galectin-3 by Hu, Shuxian, Kuwabara, Rei, Beukema, Martin, Ferrari, Michela, de Haan, Bart J., Walvoort, Marthe T.C., de Vos, Paul, Smink, Alexandra M.

“…•Pectins prevent pancreatic β-cell damage during oxidative and inflammatory stress.•Pectin with lower DM value is more efficacious than higher-DM pectins in…”
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Long-term Functioning of Allogeneic Islets in Subcutaneous Tissue Pretreated With a Novel Cyclic Peptide Without Immunosuppressive Medication by Kuwabara, Rei, Hamaguchi, Masahide, Fukuda, Takuya, Sakai, Hiroki, Inui, Makoto, Sakaguchi, Shimon, Iwata, Hiroo

“…There exists a need for a minimally invasive method of islet transplantation without immunosuppressive drugs for the treatment of type 1 diabetes. In diabetic…”
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Toll-like receptor 2-modulating pectin-polymers in alginate-based microcapsules attenuate immune responses and support islet-xenograft survival by Hu, Shuxian, Kuwabara, Rei, Navarro Chica, Carlos E., Smink, Alexandra M., Koster, Taco, Medina, Juan D., de Haan, Bart J., Beukema, Martin, Lakey, Jonathan R.T., García, Andrés J., de Vos, Paul

“…Encapsulation of pancreatic islets in alginate-microcapsules is used to reduce or avoid the application of life-long immunosuppression in preventing rejection…”
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Extracellular matrix inclusion in immunoisolating alginate-based microcapsules promotes longevity, reduces fibrosis, and supports function of islet allografts in vivo by Kuwabara, Rei, Qin, Tian, Alberto Llacua, L., Hu, Shuxian, Boekschoten, Mark V, de Haan, Bart J., Smink, Alexandra M., de Vos, Paul

“…Immunoisolation of pancreatic-islets in alginate-microcapsules is applied to treat diabetes. However, long-term islet function is limited, which might be due…”
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Applying Immunomodulation to Promote Longevity of Immunoisolated Pancreatic Islet Grafts by Kuwabara, Rei, Hu, Shuxian, Smink, Alexandra M, Orive, Gorka, Lakey, Jonathan R T, de Vos, Paul

“…Islet transplantation is a promising therapy for insulin-dependent diabetes, but large-scale application is hampered by the lack of a consistent source of…”
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Quantitative Cell Subset Analysis Using Antibody Microarrays by Ogasawara, Tomoko, Kuwabara, Rei, Kozai, Katsuyuki, Kato, Koichi

“…The expression patterns of surface antigens are associated with the differentiation status and functional characteristics of mammalian cells. To analyze the…”
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Xenotransplantation of Encapsulated Co-Aggregates of Sertoli Cells and Islet Cells by Kuwabara, Rei, Takemoto, Naohiro, Iwata, HIroo

“…Transplantation therapy utilising isolated, donor islets of Langer hans (islets) has been employed successfully to treat insulin-dependent diabetes mellitus…”
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In vivo vascularization and islet function in a microwell device for pancreatic islet transplantation by Smink, Alexandra M, Skrzypek, Katarzyna, Liefers-Visser, Jolanda A L, Kuwabara, Rei, de Haan, Bart J, de Vos, Paul, Stamatialis, Dimitrios

“…Islet encapsulation in membrane-based devices could allow for transplantation of donor islet tissue in the absence of immunosuppression. To achieve long-term…”
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