Search Results - "Kuwabara, Jill T"

Revisiting Cardiac Cellular Composition by Pinto, Alexander R, Ilinykh, Alexei, Ivey, Malina J, Kuwabara, Jill T, D’Antoni, Michelle L, Debuque, Ryan, Chandran, Anjana, Wang, Lina, Arora, Komal, Rosenthal, Nadia A, Tallquist, Michelle D

“…RATIONALE:Accurate knowledge of the cellular composition of the heart is essential to fully understand the changes that occur during pathogenesis and to devise…”
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Consequences of PDGFRα + fibroblast reduction in adult murine hearts by Kuwabara, Jill T, Hara, Akitoshi, Bhutada, Sumit, Gojanovich, Greg S, Chen, Jasmine, Hokutan, Kanani, Shettigar, Vikram, Lee, Anson Y, DeAngelo, Lydia P, Heckl, Jack R, Jahansooz, Julia R, Tacdol, Dillon K, Ziolo, Mark T, Apte, Suneel S, Tallquist, Michelle D

“…Fibroblasts produce the majority of collagen in the heart and are thought to regulate extracellular matrix (ECM) turnover. Although fibrosis accompanies many…”
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Natriuresis During an Acute Intravenous Sodium Chloride Infusion in Conscious Sprague Dawley Rats Is Mediated by a Blood Pressure-Independent α1-Adrenoceptor-Mediated Mechanism by Frame, Alissa A., Nist, Kayla M., Kim, Kiyoung, Kuwabara, Jill T., Wainford, Richard D.

“…The mechanisms that sense alterations in total body sodium content to facilitate sodium homeostasis in response to an acute sodium challenge that does not…”
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Norepinephrine-evoked salt-sensitive hypertension requires impaired renal sodium chloride cotransporter activity in Sprague-Dawley rats by Walsh, Kathryn R, Kuwabara, Jill T, Shim, Joon W, Wainford, Richard D

“…Recent studies have implicated a role of norepinephrine (NE) in the activation of the sodium chloride cotransporter (NCC) to drive the development of…”
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Sensory Afferent Renal Nerve Activated Gαi2 Subunit Proteins Mediate the Natriuretic, Sympathoinhibitory and Normotensive Responses to Peripheral Sodium Challenges by Moreira, Jesse D., Nist, Kayla M., Carmichael, Casey Y., Kuwabara, Jill T., Wainford, Richard D.

“…We have previously reported that brain Gαi 2 subunit proteins are required to maintain sodium homeostasis and are endogenously upregulated in the hypothalamic…”
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Tracking Adventitial Fibroblast Contribution to Disease: A Review of Current Methods to Identify Resident Fibroblasts by Kuwabara, Jill T, Tallquist, Michelle D

“…Cells present in the adventitia, or outermost layer of the blood vessel, contribute to the progression of vascular diseases, such as atherosclerosis,…”
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Resident fibroblast expansion during cardiac growth and remodeling by Ivey, Malina J., Kuwabara, Jill T., Pai, Jonathan T., Moore, Richard E., Sun, Zuyue, Tallquist, Michelle D.

“…Cardiac fibrosis, denoted by the deposition of extracellular matrix, manifests with a variety of diseases such as hypertension, diabetes, and myocardial…”
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Platelet-derived growth factor receptor-α is essential for cardiac fibroblast survival by Ivey, Malina J, Kuwabara, Jill T, Riggsbee, Kara L, Tallquist, Michelle D

“…Platelet-derived growth factor receptor α (PDGFRα), a receptor tyrosine kinase required for cardiac fibroblast development, is uniquely expressed by…”
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Regulation of extracellular matrix composition by fibroblasts during perinatal cardiac maturation by Kuwabara, Jill T., Hara, Akitoshi, Heckl, Jack R., Peña, Brisa, Bhutada, Sumit, DeMaris, Regan, Ivey, Malina J., DeAngelo, Lydia P., Liu, Xiaoting, Park, Juwon, Jahansooz, Julia R., Mestroni, Luisa, McKinsey, Timothy A., Apte, Suneel S., Tallquist, Michelle D.

“…Cardiac fibroblasts are the main non-myocyte population responsible for extracellular matrix (ECM) production. During perinatal development, fibroblast…”
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Gαi2-Protein–Mediated Signal Transduction: Central Nervous System Molecular Mechanism Countering the Development of Sodium-Dependent Hypertension by Wainford, Richard D, Carmichael, Casey Y, Pascale, Crissey L, Kuwabara, Jill T

“…Excess dietary salt intake is an established cause of hypertension. At present, our understanding of the neuropathophysiology of salt-sensitive hypertension is…”
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Hypothalamic Paraventricular Nucleus Gαi2 (Guanine Nucleotide–Binding Protein Alpha Inhibiting Activity Polypeptide 2) Protein–Mediated Neural Control of the Kidney and the Salt Sensitivity of Blood Pressure by Carmichael, Casey Y., Kuwabara, Jill T., Pascale, Crissey L., Moreira, Jesse D., Mahne, Sarah E., Kapusta, Daniel R., Rosene, Douglas L., Williams, Jonathan S., Cunningham, J. Thomas, Wainford, Richard D.

“…We have previously reported that in salt-resistant rat phenotypes brain, Gαi2 (guanine nucleotide–binding protein alpha inhibiting activity polypeptide 2)…”
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Role of the afferent renal nerves in sodium homeostasis and blood pressure regulation in rats by Frame, Alissa A., Carmichael, Casey Y., Kuwabara, Jill T., Cunningham, J. Thomas, Wainford, Richard D.

“…New Findings What is the central question of this study? What are the differential roles of the mechanosensitive and chemosensitive afferent renal nerves in…”
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Hypothalamic Paraventricular Nucleus Gαi 2 (Guanine Nucleotide-Binding Protein Alpha Inhibiting Activity Polypeptide 2) Protein-Mediated Neural Control of the Kidney and the Salt Sensitivity of Blood Pressure by Carmichael, Casey Y, Kuwabara, Jill T, Pascale, Crissey L, Moreira, Jesse D, Mahne, Sarah E, Kapusta, Daniel R, Rosene, Douglas L, Williams, Jonathan S, Cunningham, J Thomas, Wainford, Richard D

“…We have previously reported that in salt-resistant rat phenotypes brain, Gαi (guanine nucleotide-binding protein alpha inhibiting activity polypeptide 2)…”
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Central Nervous System Gαi2-Subunit Proteins Maintain Salt Resistance via a Renal Nerve–Dependent Sympathoinhibitory Pathway by Kapusta, Daniel R, Pascale, Crissey L, Kuwabara, Jill T, Wainford, Richard D

“…In salt-resistant phenotypes, chronic elevated dietary sodium intake evokes suppression of renal sodium-retaining mechanisms to maintain sodium homeostasis and…”
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Brain Gαi2-subunit protein-gated pathways are required to mediate the centrally evoked sympathoinhibitory mechanisms activated to maintain sodium homeostasis by Wainford, Richard D, Pascale, Crissey L, Kuwabara, Jill T

“…OBJECTIVE:We have previously demonstrated a role of GPCR-activated brain Gαi2-subunit protein-gated pathways in the natriuretic responses evoked by exogenous…”
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Abstract 374: Cardiac Fibroblasts are Essential During Pathological Stress by Kuwabara, Jill T

“…Abstract only Cardiac fibroblasts reportedly play a role in normal heart function and are responsible for adverse remodeling after heart injury. Although…”
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Sensory Afferent Renal Nerve Activated Gαi 2 Subunit Proteins Mediate the Natriuretic, Sympathoinhibitory and Normotensive Responses to Peripheral Sodium Challenges by Moreira, Jesse D, Nist, Kayla M, Carmichael, Casey Y, Kuwabara, Jill T, Wainford, Richard D

“…We have previously reported that brain Gαi subunit proteins are required to maintain sodium homeostasis and are endogenously upregulated in the hypothalamic…”
Get full text

Natriuresis During an Acute Intravenous Sodium Chloride Infusion in Conscious Sprague Dawley Rats Is Mediated by a Blood Pressure-Independent α 1 -Adrenoceptor-Mediated Mechanism by Frame, Alissa A, Nist, Kayla M, Kim, Kiyoung, Kuwabara, Jill T, Wainford, Richard D

“…The mechanisms that sense alterations in total body sodium content to facilitate sodium homeostasis in response to an acute sodium challenge that does not…”
Get full text

Abstract 26: PVN GaI2 Subunit Proteins - The Key to a Salt-resistant Phenotype? by Wainford, Richard D, Kuwabara, Jill T

“…Abstract only Aim: Endogenous up-regulation of PVN Gαi 2 proteins facilitates sympathoinhibition and normotension during chronic Na + challenge in…”
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Consequences of PDGFR[alpha].sup.+ fibroblast reduction in adult murine hearts by Kuwabara, Jill T, Hara, Akitoshi, Bhutada, Sumit, Gojanovich, Greg S, Chen, Jasmine, Hokutan, Kanani, Shettigar, Vikram, Lee, Anson Y, DeAngelo, Lydia P, Heckl, Jack R, Jahansooz, Julia R, Tacdol, Dillon K, Ziolo, Mark T, Apte, Suneel S, Tallquist, Michelle D

“…Fibroblasts produce the majority of collagen in the heart and are thought to regulate extracellular matrix (ECM) turnover. Although fibrosis accompanies many…”
Get full text